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Protein

Pyruvate kinase

Gene

Pcal_0029

Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gap)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (apgM)
  4. Enolase (eno)
  5. Pyruvate kinase (Pcal_0029)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciPCAL410359:GIX2-29-MONOMER
UniPathwayi
UPA00109;UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Ordered Locus Names:Pcal_0029Imported
OrganismiPyrobaculum calidifontis (strain JCM 11548 / VA1)Imported
Taxonomic identifieri410359 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000001431 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi410359.Pcal_0029

Structurei

3D structure databases

ProteinModelPortaliA3MS52
SMRiA3MS52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 343PKInterPro annotationAdd BLAST334
Domaini353 – 426PK_CInterPro annotationAdd BLAST74

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04120 Archaea
COG0469 LUCA
HOGENOMiHOG000021558
KOiK00873
OMAiKHEAIEQ
OrthoDBiPOG093Z02OJ

Family and domain databases

Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 1 hit
SSF52935 SSF52935, 1 hit

Sequencei

Sequence statusi: Complete.

A3MS52-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKASAKPLT KRVLTLGPAT DALSIGEVFR FLDLADGVRI NLAHATPGEV
60 70 80 90 100
EARVRTVRTY EAERGRPLAL VVDLRGPSVR VGKTPPISVE RGQEVVFKPG
110 120 130 140 150
RESDGSFIPV PELFFAVVEP GDVVLMLDGK LRMRVVSAGP GAARALAESS
160 170 180 190 200
GVVESGKAVV IEGKDFDLPS PTDDDIETLR GIAHLAREVD YVSVSLARGC
210 220 230 240 250
GDVEKARAIL RELGFESQVA VKIETRRAVE ALEELAQCGD YLVVARGDLG
260 270 280 290 300
LHYGLESLPV VQRRVVYTAL RLGKPVAVAT QLLDSLQSYP TPTRAEVNDV
310 320 330 340 350
FTTASMGVDS VWLTNETASG RYPIEAASWL TKILNAVEYH VPQRPLPNGV
360 370 380 390 400
RDRFAKALVE LAEDLGADIL IYSMSGALAR RVAKFRPLQL VYVGTPSMKT
410 420 430 440 450
ARALSVVWAL EPHHIPAPSY EEGLAKLIAM RGKAPYVATY GIRGGEHVIK

LFIEED
Length:456
Mass (Da):49,332
Last modified:April 3, 2007 - v1
Checksum:iE78D6FD9AD933B58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000561 Genomic DNA Translation: ABO07469.1

Genome annotation databases

EnsemblBacteriaiABO07469; ABO07469; Pcal_0029
KEGGipcl:Pcal_0029

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000561 Genomic DNA Translation: ABO07469.1

3D structure databases

ProteinModelPortaliA3MS52
SMRiA3MS52
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi410359.Pcal_0029

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO07469; ABO07469; Pcal_0029
KEGGipcl:Pcal_0029

Phylogenomic databases

eggNOGiarCOG04120 Archaea
COG0469 LUCA
HOGENOMiHOG000021558
KOiK00873
OMAiKHEAIEQ
OrthoDBiPOG093Z02OJ

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00188

BioCyciPCAL410359:GIX2-29-MONOMER

Family and domain databases

Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 1 hit
SSF52935 SSF52935, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA3MS52_PYRCJ
AccessioniPrimary (citable) accession number: A3MS52
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 7, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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