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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Burkholderia mallei (strain NCTC 10247)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:BMA10247_2291
OrganismiBurkholderia mallei (strain NCTC 10247)
Taxonomic identifieri320389 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000180001 – 594Arginine--tRNA ligaseAdd BLAST594

Proteomic databases

PRIDEiA3MNI3

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA3MNI3
SMRiA3MNI3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi139 – 149"HIGH" regionAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000247214
KOiK01887
OMAiNKPLHLG

Family and domain databases

CDDicd00671 ArgRS_core, 1 hit
Gene3Di3.30.1360.70, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00123 Arg_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR005148 Arg-tRNA-synth_N
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956 PTHR11956, 1 hit
PfamiView protein in Pfam
PF03485 Arg_tRNA_synt_N, 1 hit
PF05746 DALR_1, 1 hit
PF00750 tRNA-synt_1d, 1 hit
PRINTSiPR01038 TRNASYNTHARG
SMARTiView protein in SMART
SM01016 Arg_tRNA_synt_N, 1 hit
SM00836 DALR_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF55190 SSF55190, 1 hit
TIGRFAMsiTIGR00456 argS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A3MNI3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPAQKHTLE TLLENSVKQV VQASKGDADA AFVLPAIALE RPKVAAHGDV
60 70 80 90 100
ACNVALQLAK PLGANPRQLA EQIVAALTAQ PEAAGLVDAA EIAGPGFINL
110 120 130 140 150
RLTPASKQAV IGAVLAQGRA FGASERDHDK RVLLEFVSAN PTGPLHVGHG
160 170 180 190 200
RQAALGDALA NVLASQGYAV HREFYYNDAG VQIGNLAIST QARARGLKPG
210 220 230 240 250
DAGWPEAAYN GEYIADIARD YLNGETVAAS DGEPVTGKRD VEDLEAIRKF
260 270 280 290 300
AVTYLRREQD MDLKAFGVKF DQYYLESSLY TEGRVEKTVD ALIAAGMTYE
310 320 330 340 350
QEGALWLRTT DEGDDKDRVM RKTDGTYTYF VPDVAYHVTK WERGFTKVIN
360 370 380 390 400
IQGSDHHGTI ARVRAGLQGL HIGIPKGYPD YVLHKMVTVM RDGQEVKISK
410 420 430 440 450
RAGSYVTVRD LIEWSGGATP GSEGSPELLD EATITRGRDA VRFFLISRKA
460 470 480 490 500
DTEFVFDIDL ALKQNDENPV YYVQYAHARI CSVINEWKSR YGATDALLPG
510 520 530 540 550
ADLSPLDSKQ AMALMQKLAE YPDVLAHAAG ELAPHAVAFY LRELASEFHS
560 570 580 590
FYNAERVLVD EQAPRTARVA LLAATRQVLE NGLAMLGVSA PSKM
Length:594
Mass (Da):64,578
Last modified:April 3, 2007 - v1
Checksum:iD8DC2150D8A83604
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000548 Genomic DNA Translation: ABO04778.1
RefSeqiWP_004189649.1, NZ_CP007802.1

Genome annotation databases

EnsemblBacteriaiABO04778; ABO04778; BMA10247_2291
KEGGibmaz:BM44_965
bmn:BMA10247_2291
PATRICifig|320389.8.peg.1071

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000548 Genomic DNA Translation: ABO04778.1
RefSeqiWP_004189649.1, NZ_CP007802.1

3D structure databases

ProteinModelPortaliA3MNI3
SMRiA3MNI3
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA3MNI3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO04778; ABO04778; BMA10247_2291
KEGGibmaz:BM44_965
bmn:BMA10247_2291
PATRICifig|320389.8.peg.1071

Phylogenomic databases

HOGENOMiHOG000247214
KOiK01887
OMAiNKPLHLG

Family and domain databases

CDDicd00671 ArgRS_core, 1 hit
Gene3Di3.30.1360.70, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00123 Arg_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR005148 Arg-tRNA-synth_N
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956 PTHR11956, 1 hit
PfamiView protein in Pfam
PF03485 Arg_tRNA_synt_N, 1 hit
PF05746 DALR_1, 1 hit
PF00750 tRNA-synt_1d, 1 hit
PRINTSiPR01038 TRNASYNTHARG
SMARTiView protein in SMART
SM01016 Arg_tRNA_synt_N, 1 hit
SM00836 DALR_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF55190 SSF55190, 1 hit
TIGRFAMsiTIGR00456 argS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYR_BURM7
AccessioniPrimary (citable) accession number: A3MNI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: October 10, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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