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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayi
UPA00223;UER01008

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
Gene namesi
Name:mqoUniRule annotation
Ordered Locus Names:A1S_0923
OrganismiAcinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377)
Taxonomic identifieri400667 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000998641 – 546Probable malate:quinone oxidoreductaseAdd BLAST546

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000109379
KOiK00116
OrthoDBiPOG091H0B7C

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00212 MQO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR006231 MQO
PfamiView protein in Pfam
PF06039 Mqo, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR01320 mal_quin_oxido, 1 hit

Sequencei

Sequence statusi: Complete.

A3M361-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKFLKYLLV LIILILIAGI VFLFRPIASK QVQTAKDEPV VDAVLVGGGI
60 70 80 90 100
MSATLGTYFT ELEPNWQIRM FERLDQVAQE SSNGFNNAGT GHSGFMEMNY
110 120 130 140 150
TEEKNGKMEI AKAEKVASQF EVAKQFWSYQ VKQGVLAEPK TFINPVPHIA
160 170 180 190 200
FVWGDNVKFL EKRYAAMIQS PLFKGMKFTE DPAVIKQWAP LVMTDRDPTQ
210 220 230 240 250
KVAATRMEVG SDVNYGSITK QLVNHLNQNP NFKLQTSTEV TGISQNDDKT
260 270 280 290 300
WTVSFKNLKT GKTDHVKTRF VFIGAGGAAV KLLQLTGLPE AKQYAGFPVG
310 320 330 340 350
GEFLITDNPA ITAQHTAKVY GRAELGAPPM SVPHIDTRYI DGKKYVLFGP
360 370 380 390 400
FATYSNKFLK NGSQLDLLAS TNKSNVLPMT TVGLENLDLV KYLVSQVMMS
410 420 430 440 450
DEDRLNELRK YYPDAKAEDW RLSQGGQRVQ IIKKEPGKPA TLQFGTEIFA
460 470 480 490 500
SKDGAVTALL GASPGASTSP YIMLNLLEKA FPQQTEGKWN QKLHEIVVSY
510 520 530 540
KQDLSKDPVL LDKVRQYTSS TLGLNYTSPF KAANDETAAA PVAKAN
Length:546
Mass (Da):60,435
Last modified:September 2, 2008 - v2
Checksum:i2AA186835981B9E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000521 Genomic DNA Translation: ABO11355.2

Genome annotation databases

EnsemblBacteriaiABO11355; ABO11355; A1S_0923
KEGGiacb:A1S_0923

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000521 Genomic DNA Translation: ABO11355.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO11355; ABO11355; A1S_0923
KEGGiacb:A1S_0923

Phylogenomic databases

HOGENOMiHOG000109379
KOiK00116
OrthoDBiPOG091H0B7C

Enzyme and pathway databases

UniPathwayi
UPA00223;UER01008

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00212 MQO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR006231 MQO
PfamiView protein in Pfam
PF06039 Mqo, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR01320 mal_quin_oxido, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMQO_ACIBT
AccessioniPrimary (citable) accession number: A3M361
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: October 10, 2018
This is version 70 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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