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Protein

V-type proton ATPase subunit a

Gene

VPH3

Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseImported
Biological processHydrogen ion transportUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit aUniRule annotation
Gene namesi
Name:VPH3Imported
ORF Names:PICST_67737Imported
OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)Imported
Taxonomic identifieri322104 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
Proteomesi
  • UP000002258 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei502 – 525HelicalUniRule annotationAdd BLAST24
Transmembranei546 – 565HelicalUniRule annotationAdd BLAST20
Transmembranei632 – 652HelicalUniRule annotationAdd BLAST21
Transmembranei664 – 685HelicalUniRule annotationAdd BLAST22
Transmembranei725 – 744HelicalUniRule annotationAdd BLAST20
Transmembranei856 – 879HelicalUniRule annotationAdd BLAST24
Transmembranei885 – 908HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi322104.XP_001385041.2

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2189 Eukaryota
COG1269 LUCA
HOGENOMiHOG000037059
InParanoidiA3LUS8
KOiK02154
OMAiIPSFMNT
OrthoDBiEOG092C0YCY

Family and domain databases

InterProiView protein in InterPro
IPR002490 V-ATPase_116kDa_su
IPR026028 V-type_ATPase_116kDa_su_euka
PANTHERiPTHR11629 PTHR11629, 1 hit
PfamiView protein in Pfam
PF01496 V_ATPase_I, 2 hits
PIRSFiPIRSF001293 ATP6V0A1, 1 hit

Sequencei

Sequence statusi: Complete.

A3LUS8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPIQLSDDS SSVAPEAIFR SAPMTLVQFY VTIELARDMV YTLGNLGDVH
60 70 80 90 100
FRDLNSKLTP FQRTFVSELR NIDTMESQLA FLNSIMIKYE TIKSDVFVNL
110 120 130 140 150
KADMDPLPTT SEMDDMKQKI TTFYDRIKHL DNSYNVLNEQ KMAVVENRHV
160 170 180 190 200
LNAVTDFHSS SLIGGYNESR ISLSLSDGAD DDNVALLNNR NNSMELGSET
210 220 230 240 250
INLEESGFDA ISGTIVREKV PLLRNILWRT MRGNLYFHDV PIDNEKLFDY
260 270 280 290 300
NATQEELVNK NVFIVYIHGD LLRTRVRRII QSLDGNIFDN VNGGASARAA
310 320 330 340 350
TSSELNAKIT DLNNIVMTTK NHLIAELLIF QEAYPDYCFI VQRDKLIYQT
360 370 380 390 400
LNKFDEDSTR RCLVGEGWIP TSDFGLIRQT LRHLVREKTR RGDGESDSQE
410 420 430 440 450
SVPLTQQGSS PNPVSQTYTN LGSGNSSLFA IDDATDDFSE LEDEEYGSLI
460 470 480 490 500
AIVNELSTNR TPPTYHNVNK FTSAFQSIID AYGIATYQEV NPGLATIVTF
510 520 530 540 550
PFMFAIMFGD IGHGLIVLLI SLYLIKNEVH FGAMRNKDEI FEMAFNGRYI
560 570 580 590 600
ILLMGLFSMY TGFLYNDIFS KTITLFKSGW VWNFPKDYDF TKDGPVTLVA
610 620 630 640 650
EKAARTYPIG LDWAWHGAEN NLLFTNSYKM KLSVLMGFVH MNYSLFFSLV
660 670 680 690 700
NYRYFKSRVD IIGNFIPGFL FMQSIFGYLS LTIVYKWSVD WLGKGKQPPG
710 720 730 740 750
LLNMLINMFL APGKVEEQLY PGQKYIQVFL VLVALVCVPW ILVYKPLTLK
760 770 780 790 800
RQNDRAIQLG YKDLHSQANH SIQLHEEMEA TQLEEDLNHD PDDDDFEISD
810 820 830 840 850
DDFHFPNDIE PLHHNSTSHG EDGSDFNFGD IVIHQVIHTI EFCLNCVSHT
860 870 880 890 900
ASYLRLWALS LAHAQLSTVL WTMTIQNAFY TTGNAGIAMV VALFGLWFIL
910 920 930 940
TVCILVLMEG TSAMLHSLRL HWVEAMSKFF EGEGYAYEPF TFKSIDL
Length:947
Mass (Da):107,753
Last modified:July 24, 2007 - v2
Checksum:i5EE114B33CD0D2FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000499 Genomic DNA Translation: ABN67012.2
RefSeqiXP_001385041.2, XM_001385004.1

Genome annotation databases

EnsemblFungiiABN67012; ABN67012; PICST_67737
GeneIDi4839578
KEGGipic:PICST_67737

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000499 Genomic DNA Translation: ABN67012.2
RefSeqiXP_001385041.2, XM_001385004.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi322104.XP_001385041.2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiABN67012; ABN67012; PICST_67737
GeneIDi4839578
KEGGipic:PICST_67737

Phylogenomic databases

eggNOGiKOG2189 Eukaryota
COG1269 LUCA
HOGENOMiHOG000037059
InParanoidiA3LUS8
KOiK02154
OMAiIPSFMNT
OrthoDBiEOG092C0YCY

Family and domain databases

InterProiView protein in InterPro
IPR002490 V-ATPase_116kDa_su
IPR026028 V-type_ATPase_116kDa_su_euka
PANTHERiPTHR11629 PTHR11629, 1 hit
PfamiView protein in Pfam
PF01496 V_ATPase_I, 2 hits
PIRSFiPIRSF001293 ATP6V0A1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA3LUS8_PICST
AccessioniPrimary (citable) accession number: A3LUS8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: July 24, 2007
Last modified: November 7, 2018
This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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