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Entry version 93 (31 Jul 2019)
Sequence version 2 (24 Jul 2007)
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Protein
Submitted name:

ABC transporter

Gene

CDR4.2

Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi872 – 879ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransportSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ABC transporterImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDR4.2Imported
ORF Names:PICST_59143Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri322104 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeScheffersomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002258 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei511 – 533HelicalSequence analysisAdd BLAST23
Transmembranei545 – 567HelicalSequence analysisAdd BLAST23
Transmembranei587 – 610HelicalSequence analysisAdd BLAST24
Transmembranei622 – 641HelicalSequence analysisAdd BLAST20
Transmembranei653 – 672HelicalSequence analysisAdd BLAST20
Transmembranei761 – 778HelicalSequence analysisAdd BLAST18
Transmembranei1244 – 1273HelicalSequence analysisAdd BLAST30
Transmembranei1294 – 1317HelicalSequence analysisAdd BLAST24
Transmembranei1323 – 1343HelicalSequence analysisAdd BLAST21
Transmembranei1355 – 1373HelicalSequence analysisAdd BLAST19
Transmembranei1443 – 1464HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini147 – 401ABC transporterInterPro annotationAdd BLAST255
Domaini836 – 1080ABC transporterInterPro annotationAdd BLAST245

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1112 – 1139Sequence analysisAdd BLAST28

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABC transporter superfamily.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0065 Eukaryota
COG0842 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000162078

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A3LUN9

Identification of Orthologs from Complete Genome Data

More...
OMAi
ITHFFFI

Database of Orthologous Groups

More...
OrthoDBi
37708at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03233 ABCG_PDR_domain1, 1 hit
cd03232 ABCG_PDR_domain2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR029481 ABC_trans_N
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR034001 ABCG_PDR_1
IPR034003 ABCG_PDR_2
IPR005285 Drug-R_PDR/CDR
IPR027417 P-loop_NTPase
IPR010929 PDR_CDR_ABC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01061 ABC2_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PF14510 ABC_trans_N, 1 hit
PF06422 PDR_CDR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00956 3a01205, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A3LUN9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTPTMTDDS SQEAHASDRT EFNQYDGFNQ VVENEIRELA RNPSRISVDT
60 70 80 90 100
ASLHSSSLAL VRTLTNASQI PGQNPMVENS SEYIDPRLDP CSEQFDSKFW
110 120 130 140 150
VQNLRKLVLS DAEYYKPASL GLAYKNLRAY GLDVDTDYQT TFGNGIFKML
160 170 180 190 200
NRYARRITGK ESSYDILKPM DGILLPGELT VVLGRPGAGC TTLLKTLSTQ
210 220 230 240 250
TYGFQVDKES IISYDGFTPS DIKKHYRGDV VYCSETEKHF PHLTVWDTLY
260 270 280 290 300
LAAKLRTPQN RPLGVSRELY ANHMTEVVLA TYGLTNTKYT KVGDDFVRGV
310 320 330 340 350
SGGERKRVSI AEVALNSALI QCWDNSTRGL DAATALEFVR ALKASAQVSK
360 370 380 390 400
ATPLVAIYQC SQDGYDLFDK VILMYEGYQI FFGNAKKAKQ YFIDMGYECP
410 420 430 440 450
QRQTTADFLT SLTNPAERIP RKGYEAQVPR TPEEFYNYWQ KSPQRQELLS
460 470 480 490 500
QIDSYLNEHL ESNSRSEFHE SHIAKQARHT NPGSSYTVSF LMQVRYVVER
510 520 530 540 550
NILRTKGDPS FMLFQIGGNI FIAFILCSIF YNLQPTTESF YSRTAAMFFA
560 570 580 590 600
ILFNANSSML EIFSLYEARS VVEKHKTYAL YHPAADAIGS IITELPTKII
610 620 630 640 650
TCIGFNLVYY FMIHFRREPG HFFFYLLVNF TATLAMSHLF RSIGASTKTM
660 670 680 690 700
SQAMTPSVIL LLAFVIFTGF IIPTPDMHGW CRWINYINPI AYAFEALIAN
710 720 730 740 750
EFHDRDFICS RFVPSGGSYP VDGPYRICSV VGSVVGENYV NGDAFINESF
760 770 780 790 800
KYYDGHKWRN WGIVLAFAIF FMFTYVLICE YNRGSRQKGE VLLFQKRLSK
810 820 830 840 850
RKMDMEMGKM VKYTHEFSSD SSFEKNSKHE YSGNIFHWRH LSYSVKIKSE
860 870 880 890 900
NRIILDDIDG WVKPGQITAL MGATGAGKTT LLNAISDRLT AGVVTDGVRM
910 920 930 940 950
VNGRPLDADF QRSVGYVQQQ DLHLETSTVK EALKFSAYLR QPYAVSKKEK
960 970 980 990 1000
DEYVDYVINL LDMESYSDAV VGISGEGLNV EQRKRLSIGV ELVAKPKLLL
1010 1020 1030 1040 1050
FLDEPTSGLD SQTAWSICKL IRKLADSGQA IVCTIHQPSA ILLKEFDRLL
1060 1070 1080 1090 1100
FLQKGGQTVY FGDLGDYFNT LIQYFEKHGA HKCPPEANPA EWMLEVIGAA
1110 1120 1130 1140 1150
PGSHSKKDYA KVWKDSEEYK QIQRELDEME RELVKLPVND DPEKLKTFTN
1160 1170 1180 1190 1200
PMWKQYVLVT ERVLQQYWRT PSYTYNKVTL SVLSSLFNGF AFFKADRSLQ
1210 1220 1230 1240 1250
GLQNQMFSVF MFLVNLMTLV QQYLPHFVAQ RDLYEVRERP SRTFSWFAFI
1260 1270 1280 1290 1300
AAQITSEVPW NIFCGTLSFL SWYYPVGFYQ NAVETNTVHQ RGGYMWFAIV
1310 1320 1330 1340 1350
MFYVYSSTMG QMCMSFMELA DNATNLCIIM YSMCLGFCGV LVTKQNLPGF
1360 1370 1380 1390 1400
WIFMYRANPF TYLVSVILST GLFDTKVTCS PTEILNIPVP QGYTCEQFMG
1410 1420 1430 1440 1450
PYMSVAGGYL QSNGGQCQFC TMANTNVFLN SINADYYTRY RDMGLFVAFI
1460 1470
GINVICTVFF YWLARVPKFN RRGTKT
Length:1,476
Mass (Da):168,260
Last modified:July 24, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82E7991B4BAA48EC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP000498 Genomic DNA Translation: ABN66626.2

NCBI Reference Sequences

More...
RefSeqi
XP_001384655.2, XM_001384618.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
ABN66626; ABN66626; PICST_59143

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4838764

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pic:PICST_59143

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000498 Genomic DNA Translation: ABN66626.2
RefSeqiXP_001384655.2, XM_001384618.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiABN66626; ABN66626; PICST_59143
GeneIDi4838764
KEGGipic:PICST_59143

Phylogenomic databases

eggNOGiKOG0065 Eukaryota
COG0842 LUCA
HOGENOMiHOG000162078
InParanoidiA3LUN9
OMAiITHFFFI
OrthoDBi37708at2759

Family and domain databases

CDDicd03233 ABCG_PDR_domain1, 1 hit
cd03232 ABCG_PDR_domain2, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR029481 ABC_trans_N
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR034001 ABCG_PDR_1
IPR034003 ABCG_PDR_2
IPR005285 Drug-R_PDR/CDR
IPR027417 P-loop_NTPase
IPR010929 PDR_CDR_ABC
PfamiView protein in Pfam
PF01061 ABC2_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PF14510 ABC_trans_N, 1 hit
PF06422 PDR_CDR, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00956 3a01205, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA3LUN9_PICST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A3LUN9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: July 24, 2007
Last modified: July 31, 2019
This is version 93 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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