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Entry version 80 (26 Feb 2020)
Sequence version 1 (03 Apr 2007)
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Protein
Submitted name:

Novel protein similar to vertebrate ubiquitin specific protease 43 (USP43)

Gene

usp43a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, ProteaseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Novel protein similar to vertebrate ubiquitin specific protease 43 (USP43)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:usp43aImported
ORF Names:DKEY-247F18.1-001Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-100211-1 usp43a

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini114 – 716USPInterPro annotationAdd BLAST603

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30
Regioni60 – 92DisorderedSequence analysisAdd BLAST33
Regioni749 – 788DisorderedSequence analysisAdd BLAST40
Regioni841 – 1122DisorderedSequence analysisAdd BLAST282

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 30BasicSequence analysisAdd BLAST19
Compositional biasi76 – 92PolarSequence analysisAdd BLAST17
Compositional biasi750 – 770PolarSequence analysisAdd BLAST21
Compositional biasi895 – 911PolarSequence analysisAdd BLAST17
Compositional biasi912 – 930PolyampholyteSequence analysisAdd BLAST19
Compositional biasi931 – 952PolarSequence analysisAdd BLAST22
Compositional biasi953 – 1005PolyampholyteSequence analysisAdd BLAST53
Compositional biasi1011 – 1039PolarSequence analysisAdd BLAST29
Compositional biasi1046 – 1122PolarSequence analysisAdd BLAST77

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.SAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1870 Eukaryota
COG5560 LUCA

KEGG Orthology (KO)

More...
KOi
K11856

Database of Orthologous Groups

More...
OrthoDBi
1283205at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A3KQN0

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443 UCH, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A3KQN0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSLRETRKQ TIKAKSAKRK NKTHKSQKLF RRKSLKSLGN FMSRIVKTLG
60 70 80 90 100
TLAHLGDADQ PDAAAEDDDG GFGDTASVHN SGNYRESSAR KSSSYGSVKE
110 120 130 140 150
RLSWCYGEKT PGVQGLKNHG NTCFMNAVVQ CLSNTELLAE YLGLEQYKYE
160 170 180 190 200
LNERRINGMM KSEEVRGEVT DKLASLVRAL WTNDYTPQLS VDFKSVVAKY
210 220 230 240 250
GSQFKGNAQH DALEFLLWLL DCVHEDANLS TNNNQSRNSS SSKPGTRHSF
260 270 280 290 300
VQEHFQAQYR SSLTCPHCLK QSNTFDPFLC ISLPIPLRQT RALNVTLVFS
310 320 330 340 350
TEGQRFLRIG LAVPLFGSIS TLRAMVAEEG KLSPDQVILT EMNSGGFQRS
360 370 380 390 400
FSDEDDMTSI SESDVIYAFQ VPPHFTRGGS MRFSDFKGHR LPPSGTLSTE
410 420 430 440 450
FLNHGGSSKV LLLICNVAGS GQQATRFGPP FLMRVERTLS WDHLQQSVCN
460 470 480 490 500
KLYVFQKTAI IKVSTTELFK VRVVGGSASC SYLSPHDSRP LCHPTVDRAL
510 520 530 540 550
KLCGPGGPLH VKLIIEWDNK IKECLFGNIQ EEVIEDAESV RIQQQNHVQQ
560 570 580 590 600
HSCTLDDCFQ LYTKEEQLAP DDAWKCPHCK QMQQGMVKMS LWTLPDILIL
610 620 630 640 650
HLKRFRQVGK RRNKLSTLIR FPVSALDMTP HVVKRSQSMK NLAPLPSTWK
660 670 680 690 700
HGETDFLYDL YAVCNHHGGM HGGHYTAYCR NSVDGHWYSY DDSSVEIVPE
710 720 730 740 750
EELCTRGAYI LFYQRRNVIP PWSANSSVRG STSSSMSDHW LIRLNGDSKR
760 770 780 790 800
GSMVSRSSTT CPSSIADSPE SPVFKNEPSI EERGGFESRP FVRGIQGRSV
810 820 830 840 850
SMRSPTKTKV LPLRWSFGNK DRHKPVPASE QSPAELVEYL ESGRRPRCTK
860 870 880 890 900
DPIVSLMTRP SDKDNDAKKT AKSSSHSGLR PPEYLKIPQG QERGSSEKAM
910 920 930 940 950
GQQPASSSRS REEGTLTRRS SRKSKPDQSH SRKSSGAGIQ SSCSTPSGWE
960 970 980 990 1000
TAQKHESSDK RDQSEDKHKK GQETKRHDVF AFLKGGFIKK DSLRKSRDND
1010 1020 1030 1040 1050
SVKKADSGVK SPSGVSLSNG THSRNPEGNV STMNHGSRHG SELANGKVSR
1060 1070 1080 1090 1100
GSSDIKRSQS SSNIQSKTDL GLRRTASLHK NGTSVAQPQS VTGDRGSQST
1110 1120
LQRTRYSTNS LGRKKAVPES SF
Length:1,122
Mass (Da):124,897
Last modified:April 3, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C2C7937588B064A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX908749 Genomic DNA Translation: CAM56644.1

NCBI Reference Sequences

More...
RefSeqi
NP_001082871.1, NM_001089402.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
563983

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:563983

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX908749 Genomic DNA Translation: CAM56644.1
RefSeqiNP_001082871.1, NM_001089402.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi563983
KEGGidre:563983

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
563983
ZFINiZDB-GENE-100211-1 usp43a

Phylogenomic databases

eggNOGiKOG1870 Eukaryota
COG5560 LUCA
KOiK11856
OrthoDBi1283205at2759
PhylomeDBiA3KQN0

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 2 hits
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA3KQN0_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A3KQN0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: February 26, 2020
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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