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Protein

Dynein regulatory complex protein 9

Gene

iqcg

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Binds calmodulin when cellular Ca2+ levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (camk4) activity; contributes to the regulation of camk4 signaling cascades. Plays a role in the regulation of definitive hematopoiesis via its effects on camk4 (PubMed:24787902).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • definitive hemopoiesis Source: ZFIN

Keywordsi

Molecular functionCalmodulin-binding
Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein regulatory complex protein 9By similarity
Alternative name(s):
IQ domain-containing protein G1 Publication
Gene namesi
Name:iqcgImported
Synonyms:drc9By similarity, si:ch211-222m18.3Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 18

Organism-specific databases

ZFINiZDB-GENE-050419-109 iqcg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

Pathology & Biotechi

Disruption phenotypei

Morpholino knockdown of the protein leads to a severe reduction in the size of the caudal hematopoietic tissue at 72 hpf, a strong reduction in the number of myb-positive hematopoietic stem cells, and results in impaired definitive hematopoiesis. Contrary to wild-type, the expression of monocyte, macrophage and lymphoblast markers is strongly reduced. Likewise, hemoglobin levels are strongly reduced, suggesting impaired erythropoiesis.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi313Q → A: Loss of calmodulin binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004369971 – 346Dynein regulatory complex protein 9Add BLAST346

Proteomic databases

PaxDbiA3KQH2

Expressioni

Tissue specificityi

Detected in adult testis, and at lower levels in brain, kidney and ovary.1 Publication

Gene expression databases

BgeeiENSDARG00000068678

Interactioni

Subunit structurei

Component of the nexin-dynein regulatory complex (N-DRC) (By similarity). Interacts (via IQ domain) with calmodulin when calcium levels are low. Does not interact with calmodulin in the presence of Ca2+. Interacts with hsp70 and may form a complex with camk4 and hsp70 (PubMed:24787902).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000090196

Structurei

3D structure databases

SMRiA3KQH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini305 – 334IQPROSITE-ProRule annotationAdd BLAST30

Domaini

The IQ domain mediates interaction with calmodulin when cellular Ca2+ levels are low.1 Publication

Sequence similaritiesi

Belongs to the DRC9 family.Curated

Phylogenomic databases

eggNOGiENOG410IFH5 Eukaryota
ENOG410ZKIR LUCA
GeneTreeiENSGT00730000111263
HOGENOMiHOG000007509
HOVERGENiHBG083921
OrthoDBiEOG091G0DH2

Family and domain databases

InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
PfamiView protein in Pfam
PF00612 IQ, 1 hit
SMARTiView protein in SMART
SM00015 IQ, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit

Sequencei

Sequence statusi: Complete.

A3KQH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSVEELRAC ALLQDCADQL SVLGNIIRPG AETQQRTELH LKTAQLMAGS
60 70 80 90 100
SLSNFSGELK SQKHFKIQQT LLASDNLAKV QKDRQFVSDV INALLEELQK
110 120 130 140 150
KNNFQSLFSA VAEERKKKAE LLDIINREEE GRRQIKKLQK QLLDIRKEKT
160 170 180 190 200
EECERLEEEV AILKDQVQDM RVRTNQQGKF VKSCAEQLVY QESKHNSYKE
210 220 230 240 250
NELEDEVKML QEKIEEEKNV HFETEAFLKQ QHANLKQKLQ YWIHRYEKDM
260 270 280 290 300
EEKEQEITAL QNKRNSSQTR IQDLSKKCKD MENVVIEDRI EKEHLRAQME
310 320 330 340
KEQREKNAAT KIQAWWRGTL VRKGPRSKKA DKSKKKDGKK GKKKRK
Length:346
Mass (Da):40,662
Last modified:September 7, 2016 - v2
Checksum:i62E2ECD91BF3478E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX649600 Genomic DNA No translation available.
BX908394 Genomic DNA No translation available.
CO359834 mRNA No translation available.
RefSeqiNP_001333169.1, NM_001346240.1

Genome annotation databases

EnsembliENSDART00000175259; ENSDARP00000144131; ENSDARG00000068678
GeneIDi100322600
KEGGidre:100322600

Similar proteinsi

Entry informationi

Entry nameiDRC9_DANRE
AccessioniPrimary (citable) accession number: A3KQH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 7, 2016
Last sequence update: September 7, 2016
Last modified: July 18, 2018
This is version 70 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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