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Entry version 86 (02 Jun 2021)
Sequence version 1 (03 Apr 2007)
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Protein

Cell surface hyaluronidase

Gene

cemip2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan (PubMed:28118600).

Acts as a regulator of angiogenesis in embryos by mediating degradation of extracellular hyaluronan, thereby promoting VEGF signaling (PubMed:28118600).

Acts as a regulator of heart development during myocardial and endocardial morphogenesis: involved in the looping stage of heart morphogenesis (PubMed:21896629).

Stimulates migration of endocardial cells and increases both myocardial and endocardial fusion (PubMed:21896630).

Involved in the restriction of endocardial cushions (ECs) formation to the atrioventricular canal (AVC) (PubMed:21896630).

Also required for muscle fiber attachment (PubMed:27471259).

Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (By similarity).

By similarity4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Glycosidase, Hydrolase
Biological processAngiogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell surface hyaluronidase2 Publications (EC:3.2.1.351 Publication)
Alternative name(s):
Cell migration-inducing hyaluronidase 2By similarity
Protein frozen ventricle1 Publication
Protein wickham1 Publication
Transmembrane protein 22 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cemip2
Synonyms:frv1 Publication, tmem22 Publications, wkm1 Publication
ORF Names:si:dkey-24k20.11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-2179, cemip2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 82CytoplasmicCuratedAdd BLAST82
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei83 – 103Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini104 – 1378ExtracellularCuratedAdd BLAST1275

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryos show defects in heart morphogenesis: while heart development is normal at the linear heart tube stage, cardiac looping is lost at later developmental stages (PubMed:21896629). Defects during the endocardial morphogenesis, characterized by the formation of ectopic atrioventricular canal in the ventricular myocardium and endocardium (PubMed:21896630). Maternal-zygotic mutants also display muscle fiber detachment, associated with impaired laminin organization and ineffective fibronectin degradation at the myotendinous junction (PubMed:27471259). Defects in angiogenesis, characterized by embryos with no venous sprouting (PubMed:28118600).4 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi426V → E in hu4800; defects in angiogenesis. 1 Publication1
Mutagenesisi429W → A: Defects in angiogenesis. 1 Publication1
Mutagenesisi434R → A: Defects in angiogenesis. 1 Publication1
Mutagenesisi608F → A: Defects in angiogenesis. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002899741 – 1378Cell surface hyaluronidaseAdd BLAST1378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi171N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi264N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi360N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi527N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi639N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi696N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi742N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi854N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi905N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi996N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1069N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1160N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1221N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A3KPQ7

PeptideAtlas

More...
PeptideAtlasi
A3KPQ7

PRoteomics IDEntifications database

More...
PRIDEi
A3KPQ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically. Expressed at the 2 cell stage. Ubiquitously expressed at the 22-somite stage. Expressed in the brain and head mesenchyme, otic vesicles, fin buds, caudal vein and the heart (both myocardial and endocardial cells) at 24 hours post fertilization (hpf).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000061600, Expressed in muscle organ and 39 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A3KPQ7, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000082444

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A3KPQ7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini121 – 247G8PROSITE-ProRule annotationAdd BLAST127
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati672 – 694PbH1 1Add BLAST23
Repeati714 – 736PbH1 2Add BLAST23

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 77DisorderedSequence analysisAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi33 – 59Pro residuesSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CEMIP family.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QUM7, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153636

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A3KPQ7

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A3KPQ7

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13938, PANDER_like_TMEM2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019316, G8_domain
IPR039477, ILEI/PANDER_dom
IPR011050, Pectin_lyase_fold/virulence
IPR039473, TMEM2_PANDER-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10162, G8, 1 hit
PF15711, ILEI, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01225, G8, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51126, SSF51126, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51484, G8, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A3KPQ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQVNDGPSSH PIFVAPVNGN AQRSSGYVPG RIVPVRSPPP AKAPPPPPLK
60 70 80 90 100
PPVPPPARPS VFNLSEDGNR REQAQNQQRK NTYICVGIFF GIFLLILILV
110 120 130 140 150
LSLTSKDVLD ENCPHQNPAL RSWKPGHDLK KVVVIHSGEH YRLDSSATLY
160 170 180 190 200
SITIQAGGSV VFADDKKGSK NITLRTRHIL IEDGGALHIG APKCRYRSLA
210 220 230 240 250
TITLVGRSDE TAVTEVPGMG RKFLGVNSGG TLELHGSERM SWTFLTRTVP
260 270 280 290 300
ASGLATGDHA FQKNFSRGIN LRVVDQDTAE VLVNERFDTH ESQDDSKRLG
310 320 330 340 350
ELLKALPAGR IVALATGDSA VKNLVFETKQ TIHDLLGSNY ISDLKYRDAW
360 370 380 390 400
ALVSVIGGGN GSCTEDVREH ENHDTGGKAL ARQDFFTVDG VGFTVTAYSE
410 420 430 440 450
WSNGYPTTGF QVDAVDKVVL NLQDDVSSWN PGDRIVVAST DYSMYQAEEF
460 470 480 490 500
TLLPCPNCNR KQVQIQGKPQ FSHVGEILDG VDMRAEVALL SRNILIHGEM
510 520 530 540 550
ENSCYGGNWC QYFSYDTFGG HIKILGNFTS VHLSHIELKH MGQQREKGRY
560 570 580 590 600
PLNFHRCGDV DQSGGYSNPA YVDSLSIHHS FSRCVTVHAT NGLLVKDTVG
610 620 630 640 650
YDTLGHCFFL KDGIEQRNIF FHNLGLLTRP GTILPTDRND SMCTEITDRV
660 670 680 690 700
YKGYIPIPAN ECKAVSSFWI AHPNNHLISN SAAGSQDAGI WYVFHNSSTG
710 720 730 740 750
DSHGMISETK AELTPLGTFF NNRVHSNFKA GLFIDRKVKS TNATAADPRE
760 770 780 790 800
YLCLDNSARF RPHESSDPSR PRVAAIIDTL ISFKNNDLGA WIRGGDIIIR
810 820 830 840 850
NSGDGSYPKD EGSSQEVSQS LFIGESRNRG TNGGQNKYWG IGGVDGKMRT
860 870 880 890 900
LPRNKTFPIR GFQINDGPVR IFDSTFRAFS PTADRFTMAV GFSLKNIWQL
910 920 930 940 950
TPRNNLSALA FHPSVTLRAF FGRPGDWFEQ NDLDGDKNSI FHDLDGSISG
960 970 980 990 1000
YADTYVARAD NFLIRHPQCV DMPQWNGVVC SGKYSQVYIQ TQAASNLSLS
1010 1020 1030 1040 1050
ISRDEYPDKP MVLRGIRTKT SPSQQYQPVL MMGKSYTMHW NGPAPRETVL
1060 1070 1080 1090 1100
SLINFDQDDW ALLGLCYPNE TVFQITSDIY NKQNNGFEGI EDYGPVTSIA
1110 1120 1130 1140 1150
DLEKRQQERK YFFDKSAGLL WLYARARHRR DGNSYCSSAG CERVKIIATI
1160 1170 1180 1190 1200
RANQKTETCN CTANAYPKYS KPASNIVPMP KPNTEPCGAC GASQFAFSSD
1210 1220 1230 1240 1250
PWNSYLQTQI KSLSVKEEQD NDTQAYITVN AQRFDLSQSG FLLVTVDACS
1260 1270 1280 1290 1300
GKVTKNSMFS SLDTKMEQFF KTGIMKRSIV LLATRGQPAS FAGVAQYLES
1310 1320 1330 1340 1350
LGSAKTPDLQ NKVAIAFFGF LGQGGPSPQP WSTLLTCQGA KILGLQERFI
1360 1370
PLSLEEYSCP PKKDSPTRMD LELLKKIS
Length:1,378
Mass (Da):152,328
Last modified:April 3, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i675E1AB8B5650883
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G0ZDN6G0ZDN6_DANRE
Hyaluronoglucosaminidase
cemip2 tmem2
1,390Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QT53A0A2R8QT53_DANRE
Hyaluronoglucosaminidase
cemip2
1,417Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX294191 Genomic DNA Translation: CAM56649.1

NCBI Reference Sequences

More...
RefSeqi
NP_001092919.1, NM_001099449.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000133217; ENSDARP00000118976; ENSDARG00000061600

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
566851

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:566851

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294191 Genomic DNA Translation: CAM56649.1
RefSeqiNP_001092919.1, NM_001099449.1

3D structure databases

SMRiA3KPQ7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000082444

Proteomic databases

PaxDbiA3KPQ7
PeptideAtlasiA3KPQ7
PRIDEiA3KPQ7

Genome annotation databases

EnsembliENSDART00000133217; ENSDARP00000118976; ENSDARG00000061600
GeneIDi566851
KEGGidre:566851

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23670
ZFINiZDB-GENE-030131-2179, cemip2

Phylogenomic databases

eggNOGiENOG502QUM7, Eukaryota
GeneTreeiENSGT00940000153636
InParanoidiA3KPQ7
PhylomeDBiA3KPQ7

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A3KPQ7

Gene expression databases

BgeeiENSDARG00000061600, Expressed in muscle organ and 39 other tissues
ExpressionAtlasiA3KPQ7, baseline

Family and domain databases

CDDicd13938, PANDER_like_TMEM2, 1 hit
InterProiView protein in InterPro
IPR019316, G8_domain
IPR039477, ILEI/PANDER_dom
IPR011050, Pectin_lyase_fold/virulence
IPR039473, TMEM2_PANDER-like
PfamiView protein in Pfam
PF10162, G8, 1 hit
PF15711, ILEI, 2 hits
SMARTiView protein in SMART
SM01225, G8, 1 hit
SUPFAMiSSF51126, SSF51126, 1 hit
PROSITEiView protein in PROSITE
PS51484, G8, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCEIP2_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A3KPQ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: April 3, 2007
Last modified: June 2, 2021
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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