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Entry version 69 (16 Jan 2019)
Sequence version 1 (03 Apr 2007)
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Protein

Choline transporter-like protein 4

Gene

SLC44A4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-1483191 Synthesis of PC
R-BTA-425366 Transport of bile salts and organic acids, metal ions and amine compounds

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Choline transporter-like protein 4By similarity
Alternative name(s):
Solute carrier family 44 member 4By similarity
Thiamine pyrophosphate transporter 1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC44A4By similarity
Synonyms:CTL4By similarity, TPPT1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 23

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:34878 SLC44A4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 227ExtracellularSequence analysisAdd BLAST173
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 250CytoplasmicSequence analysis2
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 307ExtracellularSequence analysisAdd BLAST36
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 356CytoplasmicSequence analysisAdd BLAST28
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Topological domaini378 – 452ExtracellularSequence analysisAdd BLAST75
Transmembranei453 – 473HelicalSequence analysisAdd BLAST21
Topological domaini474 – 498CytoplasmicSequence analysisAdd BLAST25
Transmembranei499 – 519HelicalSequence analysisAdd BLAST21
Topological domaini520 – 557ExtracellularSequence analysisAdd BLAST38
Transmembranei558 – 578HelicalSequence analysisAdd BLAST21
Topological domaini579 – 594CytoplasmicSequence analysisAdd BLAST16
Transmembranei595 – 615HelicalSequence analysisAdd BLAST21
Topological domaini616 – 635ExtracellularSequence analysisAdd BLAST20
Transmembranei636 – 656HelicalSequence analysisAdd BLAST21
Topological domaini657 – 707CytoplasmicSequence analysisAdd BLAST51

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003597201 – 707Choline transporter-like protein 4Add BLAST707

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi68N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi185N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi196N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi391N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi403N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi413N-linked (GlcNAc...) asparagineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated; N-glycosylation of Asn-68 and Asn-391 is required for a proper thiamine pyrophosphate uptake.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A3KMY4

PRoteomics IDEntifications database

More...
PRIDEi
A3KMY4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000005675 Expressed in 6 organ(s), highest expression level in colon

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000042762

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1362 Eukaryota
ENOG410XS0P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160576

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007110

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG062155

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A3KMY4

KEGG Orthology (KO)

More...
KOi
K15377

Identification of Orthologs from Complete Genome Data

More...
OMAi
NFCLPGV

Database of Orthologous Groups

More...
OrthoDBi
329225at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313325

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007603 Choline_transptr-like

The PANTHER Classification System

More...
PANTHERi
PTHR12385 PTHR12385, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04515 Choline_transpo, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A3KMY4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGKQDQDKE AYGKPAKYDP SFRGPIRNRS CTDIICCVLF FLFILGYIAV
60 70 80 90 100
GILAWVYGDP KQVLYPRNST GAYCGIGENK EKPYLLYFNI FSCVLNTNII
110 120 130 140 150
AIAQNGLKCP TPQVCVSSCP EASWTVEPRQ FSQTVEQVFY AANRNFCLPG
160 170 180 190 200
VPGNMQVLQS LQQELCPSFL LPSTPALGRC FPWTNSTVPE LPGISNTSIS
210 220 230 240 250
QSISGLLDSL NARDISVKIF EDFAQSWYWI LIALGLALVL SLLFILLLRL
260 270 280 290 300
VAGPLVFVLI IGVLGVLAYG IYHCWEEYRV LRDKGASISQ LGFTTNLSAY
310 320 330 340 350
RNVQETWLAA LIILAVLEGV LLLMLIFLRQ RICIAIALLK EASRAVGYIM
360 370 380 390 400
STMFYPLVTF ALLLVCIAYW AIIALFLATS GQPQYVFWAP NSSLPGCEKV
410 420 430 440 450
PMNTSCDPME QVNSSCPGLM CVFQGYQSTG LAQRSLFNLQ IYAVLGLFWT
460 470 480 490 500
INWVLALGQC VLAGAFASFY WAFHKPRDIP TFPLGSAFLR TLRYHTGSLA
510 520 530 540 550
FGALILTLVQ IARVILEYID HKLRGAQNPL TRCILCCFKC CLWCLEKFIK
560 570 580 590 600
FLNRNAYIMI AIYGKNFCVS AKNAFMLLMR NIVRVVVLDK VTDLLLFFGK
610 620 630 640 650
LLVVGGVGVL SFFFFTGRIP SLGKTFENPQ LNYYWLPIMV SILGAYLIAS
660 670 680 690 700
GFFSVFGMCV DTLFLCFLED LERNDGSADR PYYMSKSLLK ILGKKNKGTP

GDKKRKK
Length:707
Mass (Da):78,938
Last modified:April 3, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD6FA820133A5A50
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC133403 mRNA Translation: AAI33404.1

NCBI Reference Sequences

More...
RefSeqi
NP_001076911.1, NM_001083442.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Bt.24374

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000045367; ENSBTAP00000042762; ENSBTAG00000005675

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
520625

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:520625

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133403 mRNA Translation: AAI33404.1
RefSeqiNP_001076911.1, NM_001083442.1
UniGeneiBt.24374

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042762

Proteomic databases

PaxDbiA3KMY4
PRIDEiA3KMY4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000045367; ENSBTAP00000042762; ENSBTAG00000005675
GeneIDi520625
KEGGibta:520625

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80736
VGNCiVGNC:34878 SLC44A4

Phylogenomic databases

eggNOGiKOG1362 Eukaryota
ENOG410XS0P LUCA
GeneTreeiENSGT00940000160576
HOGENOMiHOG000007110
HOVERGENiHBG062155
InParanoidiA3KMY4
KOiK15377
OMAiNFCLPGV
OrthoDBi329225at2759
TreeFamiTF313325

Enzyme and pathway databases

ReactomeiR-BTA-1483191 Synthesis of PC
R-BTA-425366 Transport of bile salts and organic acids, metal ions and amine compounds

Gene expression databases

BgeeiENSBTAG00000005675 Expressed in 6 organ(s), highest expression level in colon

Family and domain databases

InterProiView protein in InterPro
IPR007603 Choline_transptr-like
PANTHERiPTHR12385 PTHR12385, 1 hit
PfamiView protein in Pfam
PF04515 Choline_transpo, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTL4_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A3KMY4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: April 3, 2007
Last modified: January 16, 2019
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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