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Entry version 125 (07 Apr 2021)
Sequence version 1 (03 Apr 2007)
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Protein

cAMP-dependent protein kinase

Gene

prkacaa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei74ATPPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationARBA annotation, Transferase
LigandATP-bindingPROSITE-ProRule annotationARBA annotation, cAMPARBA annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-163615, PKA activation
R-DRE-164378, PKA activation in glucagon signalling
R-DRE-180024, DARPP-32 events
R-DRE-2565942, Regulation of PLK1 Activity at G2/M Transition
R-DRE-380259, Loss of Nlp from mitotic centrosomes
R-DRE-380270, Recruitment of mitotic centrosome proteins and complexes
R-DRE-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-DRE-380320, Recruitment of NuMA to mitotic centrosomes
R-DRE-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-DRE-392517, Rap1 signalling
R-DRE-422356, Regulation of insulin secretion
R-DRE-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-DRE-4420097, VEGFA-VEGFR2 Pathway
R-DRE-442720, CREB1 phosphorylation through the activation of Adenylate Cyclase
R-DRE-5578775, Ion homeostasis
R-DRE-5610785, GLI3 is processed to GLI3R by the proteasome
R-DRE-5610787, Hedgehog 'off' state
R-DRE-5620912, Anchoring of the basal body to the plasma membrane
R-DRE-5687128, MAPK6/MAPK4 signaling
R-DRE-8853659, RET signaling
R-DRE-8854518, AURKA Activation by TPX2
R-DRE-8963896, HDL assembly
R-DRE-983231, Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
cAMP-dependent protein kinaseARBA annotation (EC:2.7.11.11ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:prkacaaImported
Synonyms:zgc:158799Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-050114-6, prkacaa

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Lipoprotein, MyristateARBA annotation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A3KMS9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000100349, Expressed in retina and 30 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000110780

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 299Protein kinaseInterPro annotationAdd BLAST255
Domaini300 – 352AGC-kinase C-terminalInterPro annotationAdd BLAST53

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0616, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163111

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_63_5_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
WWACGIL

Database of Orthologous Groups

More...
OrthoDBi
963519at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313399

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14209, STKc_PKA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000961, AGC-kinase_C
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
IPR044109, STKc_PKA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A3KMS9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNAPTAKNK GNEMESVKEF LAKAKEDFLK KWENPAQNTA SLDHFERLKT
60 70 80 90 100
LGTGSFGRVM LVKHKESGQH FAMKILDKQK VVKLKQIEHT LNEKRILQAV
110 120 130 140 150
SFPFLVRLEH SFKDNTNLYM VMEYVPGGEM FSHLRRIGRF SEPHARFYAA
160 170 180 190 200
QIVLTFEYLH SLDLIYRDLK PENLLIDQQG YIQVTDFGFA KRVKGRTWTL
210 220 230 240 250
CGTPEYLAPE IILSKGYNKA VDWWALGVLI YEMAAGYPPF FADQPIQIYE
260 270 280 290 300
KIVSGKVRFP SHFSSDLKDL LRNLLQVDLT KRFGNLKNGV NDIKGHKWFA
310 320 330 340 350
TTDWIAIYQK KVEAPFIPKC KGPGDTSNFD DYDEEEIRVS ITEKCGKEFA

EF
Length:352
Mass (Da):40,593
Last modified:April 3, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i903BB931055CEBBE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR847534 Genomic DNA No translation available.
BC133159 mRNA Translation: AAI33160.1

NCBI Reference Sequences

More...
RefSeqi
NP_001076309.1, NM_001082840.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000168108; ENSDARP00000135348; ENSDARG00000100349

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
564064

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:564064

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR847534 Genomic DNA No translation available.
BC133159 mRNA Translation: AAI33160.1
RefSeqiNP_001076309.1, NM_001082840.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000110780

Proteomic databases

PRIDEiA3KMS9

Genome annotation databases

EnsembliENSDART00000168108; ENSDARP00000135348; ENSDARG00000100349
GeneIDi564064
KEGGidre:564064

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
564064
ZFINiZDB-GENE-050114-6, prkacaa

Phylogenomic databases

eggNOGiKOG0616, Eukaryota
GeneTreeiENSGT00940000163111
HOGENOMiCLU_000288_63_5_1
OMAiWWACGIL
OrthoDBi963519at2759
TreeFamiTF313399

Enzyme and pathway databases

ReactomeiR-DRE-163615, PKA activation
R-DRE-164378, PKA activation in glucagon signalling
R-DRE-180024, DARPP-32 events
R-DRE-2565942, Regulation of PLK1 Activity at G2/M Transition
R-DRE-380259, Loss of Nlp from mitotic centrosomes
R-DRE-380270, Recruitment of mitotic centrosome proteins and complexes
R-DRE-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-DRE-380320, Recruitment of NuMA to mitotic centrosomes
R-DRE-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-DRE-392517, Rap1 signalling
R-DRE-422356, Regulation of insulin secretion
R-DRE-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-DRE-4420097, VEGFA-VEGFR2 Pathway
R-DRE-442720, CREB1 phosphorylation through the activation of Adenylate Cyclase
R-DRE-5578775, Ion homeostasis
R-DRE-5610785, GLI3 is processed to GLI3R by the proteasome
R-DRE-5610787, Hedgehog 'off' state
R-DRE-5620912, Anchoring of the basal body to the plasma membrane
R-DRE-5687128, MAPK6/MAPK4 signaling
R-DRE-8853659, RET signaling
R-DRE-8854518, AURKA Activation by TPX2
R-DRE-8963896, HDL assembly
R-DRE-983231, Factors involved in megakaryocyte development and platelet production

Gene expression databases

BgeeiENSDARG00000100349, Expressed in retina and 30 other tissues

Family and domain databases

CDDicd14209, STKc_PKA, 1 hit
InterProiView protein in InterPro
IPR000961, AGC-kinase_C
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
IPR044109, STKc_PKA
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA3KMS9_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A3KMS9
Secondary accession number(s): E7F7L5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: April 7, 2021
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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