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Protein

Transcription factor MafAa

Gene

mafaa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor, possibly involved in transcription regulation during lens development, including that of crystallin genes (PubMed:11134968). Specifically binds to the alphaCE2 enhancer element of crystallin gene (PubMed:11134968).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor MafAa
Alternative name(s):
Somite Maf11 Publication
Short name:
SMaf1
Gene namesi
Name:mafaa
Synonyms:mafa, mafl
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-010605-3 mafaa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003202781 – 315Transcription factor MafAaAdd BLAST315

Proteomic databases

PaxDbiA3KMR8

Expressioni

Developmental stagei

Detected first in each somite at the 7-somite stage (12 hpf). By 24 hpf, expressed in each newly formed somite. Expression persists at low levels in each maturing somite until after 35 hpf. At 20 hpf, detected in the hindbrain and in olfactory cells.1 Publication

Gene expression databases

BgeeiENSDARG00000044155 Expressed in 24 organ(s), highest expression level in muscle tissue
ExpressionAtlasiA3KMR8 baseline

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000064832

Structurei

3D structure databases

ProteinModelPortaliA3KMR8
SMRiA3KMR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini223 – 286bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni223 – 248Basic motifAdd BLAST26
Regioni229 – 243Interaction with DNABy similarityAdd BLAST15
Regioni251 – 272Leucine-zipperAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi142 – 189His-richAdd BLAST48

Sequence similaritiesi

Belongs to the bZIP family. Maf subfamily.Curated

Phylogenomic databases

eggNOGiKOG4196 Eukaryota
ENOG41102C7 LUCA
GeneTreeiENSGT00550000074549
HOGENOMiHOG000261683
HOVERGENiHBG000313
InParanoidiA3KMR8
KOiK07595
OMAiEDLYWMS
OrthoDBiEOG091G0H46
PhylomeDBiA3KMR8
TreeFamiTF325689

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR013592 Maf_TF_N
IPR028562 MafA
IPR008917 TF_DNA-bd_sf
IPR024874 Transciption_factor_Maf_fam
PANTHERiPTHR10129 PTHR10129, 1 hit
PTHR10129:SF30 PTHR10129:SF30, 1 hit
PfamiView protein in Pfam
PF03131 bZIP_Maf, 1 hit
PF08383 Maf_N, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequencei

Sequence statusi: Complete.

A3KMR8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATDLAMSAE LPNSPLAIEY VNDFDLMKFE IKKEPPEADR YCHRLPPGSL
60 70 80 90 100
SSTPISTPCS SVPSSPSFCA PSPGSQPGQN LVNGVNNNNN NSGNGNNNTQ
110 120 130 140 150
GSSGKPQMED LYWIPNYQHH ISPEALNLTP EDAVEALIGN AHHHHHHHHH
160 170 180 190 200
QPYEGFRGQQ YVGEDLSAAT NGHHHPVHHH HHHHGHHAHA RLEDRFSDEQ
210 220 230 240 250
LVSMTVRELN RQLRGFSKEE VIRLKQKRRT LKNRGYAQSC RYKRVQQRHM
260 270 280 290 300
LESEKCTLQS QVEQLKQDVA RLIKERDLYK EKYEKLASRA FNGGGNTRDP
310
SSGNHVKTTS TDFFM
Length:315
Mass (Da):35,708
Last modified:April 3, 2007 - v1
Checksum:i3F8D0349E4E211CD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154E → K in BAB21104 (PubMed:11134968).Curated1
Sequence conflicti164 – 165ED → KN in BAB21104 (PubMed:11134968).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006324 mRNA Translation: BAB21104.2
BC133072 mRNA Translation: AAI33073.1
PIRiJC7572
RefSeqiNP_001076409.1, NM_001082940.2
UniGeneiDr.83037

Genome annotation databases

EnsembliENSDART00000064833; ENSDARP00000064832; ENSDARG00000044155
GeneIDi100000492
KEGGidre:100000492

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006324 mRNA Translation: BAB21104.2
BC133072 mRNA Translation: AAI33073.1
PIRiJC7572
RefSeqiNP_001076409.1, NM_001082940.2
UniGeneiDr.83037

3D structure databases

ProteinModelPortaliA3KMR8
SMRiA3KMR8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000064832

Proteomic databases

PaxDbiA3KMR8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000064833; ENSDARP00000064832; ENSDARG00000044155
GeneIDi100000492
KEGGidre:100000492

Organism-specific databases

CTDi100000492
ZFINiZDB-GENE-010605-3 mafaa

Phylogenomic databases

eggNOGiKOG4196 Eukaryota
ENOG41102C7 LUCA
GeneTreeiENSGT00550000074549
HOGENOMiHOG000261683
HOVERGENiHBG000313
InParanoidiA3KMR8
KOiK07595
OMAiEDLYWMS
OrthoDBiEOG091G0H46
PhylomeDBiA3KMR8
TreeFamiTF325689

Miscellaneous databases

PROiPR:A3KMR8

Gene expression databases

BgeeiENSDARG00000044155 Expressed in 24 organ(s), highest expression level in muscle tissue
ExpressionAtlasiA3KMR8 baseline

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR013592 Maf_TF_N
IPR028562 MafA
IPR008917 TF_DNA-bd_sf
IPR024874 Transciption_factor_Maf_fam
PANTHERiPTHR10129 PTHR10129, 1 hit
PTHR10129:SF30 PTHR10129:SF30, 1 hit
PfamiView protein in Pfam
PF03131 bZIP_Maf, 1 hit
PF08383 Maf_N, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMAFA_DANRE
AccessioniPrimary (citable) accession number: A3KMR8
Secondary accession number(s): Q98UK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: April 3, 2007
Last modified: November 7, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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