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Protein

Tetratricopeptide repeat protein 38

Gene

Ttc38

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 38
Short name:
TPR repeat protein 38
Gene namesi
Name:Ttc38
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2146198 Ttc38

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003215311 – 465Tetratricopeptide repeat protein 38Add BLAST465

Proteomic databases

EPDiA3KMP2
MaxQBiA3KMP2
PaxDbiA3KMP2
PeptideAtlasiA3KMP2
PRIDEiA3KMP2

2D gel databases

REPRODUCTION-2DPAGEiA3KMP2

PTM databases

iPTMnetiA3KMP2
PhosphoSitePlusiA3KMP2
SwissPalmiA3KMP2

Expressioni

Gene expression databases

BgeeiENSMUSG00000035944 Expressed in 70 organ(s), highest expression level in liver
ExpressionAtlasiA3KMP2 baseline and differential
GenevisibleiA3KMP2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000114504

Structurei

3D structure databases

ProteinModelPortaliA3KMP2
SMRiA3KMP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati104 – 137TPR 1Add BLAST34
Repeati176 – 209TPR 2Add BLAST34
Repeati248 – 281TPR 3Add BLAST34

Sequence similaritiesi

Belongs to the TTC38 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG2610 Eukaryota
ENOG410XR50 LUCA
GeneTreeiENSGT00390000002669
HOGENOMiHOG000267190
HOVERGENiHBG108613
InParanoidiA3KMP2
OMAiHSRDHIL
OrthoDBiEOG091G06CW
PhylomeDBiA3KMP2
TreeFamiTF313343

Family and domain databases

CDDicd05804 StaR_like, 1 hit
Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011990 TPR-like_helical_dom_sf
IPR033891 TTC38
PANTHERiPTHR16263 PTHR16263, 1 hit
SUPFAMiSSF48452 SSF48452, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: A3KMP2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLRDCQAWK NAGLPLSTTS NEACKLFDAT LTQYVKWTND KSLGGIEGCL
60 70 80 90 100
SKLRAADPTF AMGLAISNGL VLVGTGTSVA LDKDLALAVK TMVELSQTQT
110 120 130 140 150
LTPREQLHVS AVEMFAKGNF PRACDLWEQI LRDHPTDMLA LKFSHDAYFY
160 170 180 190 200
LGYQEQMRDS VARVYPFWTP DIPLNSYVKG IYSFGLMETN FYDQAQKLAK
210 220 230 240 250
EALSIEPTDA WSVHTVAHVH EMRAEIKDGL EFMQQSEGHW KDSDMLACHN
260 270 280 290 300
YWHWALYLIE KGDYEAALTI YDSHILPSLQ ASGTMLDVVD SCSMLYRLQM
310 320 330 340 350
EGVPLGQRWQ TVLPVTQKHT RDHILLFNDA HFLMASLGAR DLQTTRELLT
360 370 380 390 400
TLQEASKSPG ENCQHQLAKD VGLPLCQALL EAENGNPDRV LELLLPIRYR
410 420 430 440 450
IVQIGGSNAQ RDVFNQLLIH AAMTCTSSVH KNVARSLLME RDALKPNSPL
460
TERLIRRAAA VHLMQ
Length:465
Mass (Da):52,224
Last modified:February 5, 2008 - v2
Checksum:i62E91019CBF010F3
GO
Isoform 2 (identifier: A3KMP2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-186: Missing.

Show »
Length:279
Mass (Da):31,589
Checksum:i1314760C32F8A246
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RH59D6RH59_MOUSE
Tetratricopeptide repeat protein 38
Ttc38
62Annotation score:

Sequence cautioni

The sequence AAH24550 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH30849 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0317911 – 186Missing in isoform 2. 1 PublicationAdd BLAST186

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133636 mRNA Translation: BAE21760.1
BC024550 mRNA Translation: AAH24550.1 Different initiation.
BC030849 mRNA Translation: AAH30849.1 Different initiation.
BC132621 mRNA Translation: AAI32622.2
BC132623 mRNA Translation: AAI32624.2
CCDSiCCDS27724.2 [A3KMP2-1]
RefSeqiNP_001028509.2, NM_001033337.4 [A3KMP2-1]
XP_006521015.1, XM_006520952.2 [A3KMP2-2]
XP_006521016.1, XM_006520953.3 [A3KMP2-2]
UniGeneiMm.151748

Genome annotation databases

EnsembliENSMUST00000146088; ENSMUSP00000114504; ENSMUSG00000035944 [A3KMP2-1]
GeneIDi239570
KEGGimmu:239570
UCSCiuc007xdn.2 mouse [A3KMP2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTTC38_MOUSE
AccessioniPrimary (citable) accession number: A3KMP2
Secondary accession number(s): Q05C02, Q05CK3, Q3UZU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 5, 2008
Last modified: September 12, 2018
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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