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UniProtKB - A3KGV1 (ODFP2_MOUSE)

Entry version 104 (12 Aug 2020)
Sequence version 1 (03 Apr 2007)
Previous versions | rss
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Protein

Outer dense fiber protein 2

Gene

Odf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259, Loss of Nlp from mitotic centrosomes
R-MMU-380270, Recruitment of mitotic centrosome proteins and complexes
R-MMU-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-MMU-380320, Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912, Anchoring of the basal body to the plasma membrane
R-MMU-8854518, AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Outer dense fiber protein 2
Alternative name(s):
84 kDa outer dense fiber protein
Cenexin
Outer dense fiber of sperm tails protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Odf2
Synonyms:Odf84
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1098824, Odf2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Null mutations in F9 embryonic carcinoma cells eliminated distal/subdistal appendages and prevented primary cilium formation. Loss of ODF2 also disrupted two mother centriole-specific NIN dots, while leaving one dot on the proximal end of mother and daughter centrioles.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002994581 – 830Outer dense fiber protein 2Add BLAST830

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei73PhosphoserineBy similarity1
Modified residuei74PhosphoserineBy similarity1
Modified residuei92PhosphothreonineBy similarity1
Modified residuei95Phosphoserine; by TSSK41 Publication1
Modified residuei106PhosphoserineBy similarity1
Modified residuei109PhosphoserineBy similarity1
Modified residuei110PhosphothreonineBy similarity1
Modified residuei115PhosphoserineBy similarity1
Modified residuei129PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki138Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei139PhosphoserineBy similarity1
Modified residuei231PhosphothreonineBy similarity1
Modified residuei261PhosphoserineBy similarity1
Modified residuei632PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine phosphorylated (By similarity). Phosphorylated on Ser-95 by TSSK4 (PubMed:26961893).By similarity1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A3KGV1

MaxQB - The MaxQuant DataBase

More...MaxQBi		A3KGV1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A3KGV1

PeptideAtlas

More...PeptideAtlasi		A3KGV1

PRoteomics IDEntifications database

More...PRIDEi		A3KGV1

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		A3KGV1
IPI00130958

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A3KGV1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A3KGV1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis-specific (at protein level) (PubMed:9045620, PubMed:27682589). Expressed in spermatids at tubular stage V of the spermatogenic cycle (PubMed:9740324). Highly expressed in the cytoplasm of elongating spermatids (tubular stages X/XI) (PubMed:9740324). In step 14/15 spermatids of tubular stage III/IV low expression detected (PubMed:9740324). No expression detected in other testicular cells as well as the early round of spermatids (PubMed:9740324).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000026790, Expressed in testis and 307 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A3KGV1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A3KGV1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates. Associates with microtubules and forms a fibrillar structure partially linked to the microtubule network.

Interacts via its C-terminus with PLK1 (By similarity).

Interacts with ODF1 (PubMed:9045620).

Interacts with MARK4; the interaction is required for localization of ODF2 to centrioles (By similarity).

Interacts with TSSK4 (PubMed:25361759, PubMed:26961893).

Interacts with AKNA (PubMed:30787442).

By similarity4 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		201898, 5 interactors

Protein interaction database and analysis system

More...IntActi		A3KGV1, 3 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000109388

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A3KGV1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A3KGV1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili144 – 217Sequence analysisAdd BLAST74
Coiled coili245 – 423Sequence analysisAdd BLAST179
Coiled coili461 – 798Sequence analysisAdd BLAST338

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ODF2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QUXQ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063497

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018326_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A3KGV1

KEGG Orthology (KO)

More...KOi		K16479

Identification of Orthologs from Complete Genome Data

More...OMAi		KASYTNV

Database of Orthologous Groups

More...OrthoDBi		328077at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A3KGV1

TreeFam database of animal gene trees

More...TreeFami		TF328605

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026099, Odf2-rel

The PANTHER Classification System

More...PANTHERi		PTHR23162, PTHR23162, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A3KGV1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSASSSGGSP RFPSCGKNGV TSLTQKKVLR TPCGAPSVTV TKSHKRGMKG 
        60         70         80         90        100
DTVNVRRSVR VKTKVPWMPP GKSSARHVGC KWENPPHCLE ITPPSSEKLV 
       110        120        130        140        150
SVMRLSDLST EDDDSGHCKM NRYDKKIDSL MNAVGCLKSE VKMQKGERQM 
       160        170        180        190        200
AKRFLEERKE ELEEVAHELA ETEHENTVLR HNIERIKEEK DFTMLQKKHL 
       210        220        230        240        250
QQEKECLMSK LVEAEMDGAA AAKQVMALKD TIGKLKTEKQ MTCTDINTLT 
       260        270        280        290        300
RQKELLLQKL STFEETNRTL RDLLREQHCK EDSERLMEQQ GTLLKRLAEA 
       310        320        330        340        350
DSEKARLLLL LQDKDKEVEE LLQEIQCEKA QAKTASELSK SMESMRGHLQ 
       360        370        380        390        400
AQLRCKEAEN SRLCMQIKNL ERSGNQHKAE VEAIMEQLKE LKQKGDRDKE 
       410        420        430        440        450
TLKKAIRAQK ERAEKSEEYA EQLHVQLADK DLYVAEALST LESWRSRYNQ 
       460        470        480        490        500
VVKDKGDLEL EIIVLNDRVT DLVNQQQSLE EKMREDRDSL VERLHRQTAE 
       510        520        530        540        550
YSAFKLENER LKASFAPMED KLNQAHLEVQ QLKASVKNYE GMIDNYKSQV 
       560        570        580        590        600
MKTRLEADEV AAQLERCDKE NKMLKDEMNK EIEAARRQFQ SQLADLQQLP 
       610        620        630        640        650
DILKITEAKL AECQDQLQGY ERKNIDLTAI ISDLRSRIEH QGDKLEMARE 
       660        670        680        690        700
KHQASQKENK QLSQKVDELE RKLEATSAQN VEFLQVIAKR EEAIHQAQLR 
       710        720        730        740        750
LEEKTRECGS LARQLESAIE DARRQVEQTK EQALSKERAA QSKILDLETQ 
       760        770        780        790        800
LSRTKTELGQ LRRTRDDADR RYQSRLQDLK DRLEQSESTN RSMQNYVQFL 
       810        820        830
KASYANVFGD APYTSSYLTS SPIRSRSPPA
Length:830
Mass (Da):95,541
Last modified:April 3, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC840B47EC10EF82A
GO
Isoform 2 (identifier: A3KGV1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MSASSSGGSP...PCGAPSVTVT → MKDRSSTPPL...LPKPSAASSQ
     65-83: Missing.

Show »
Length:806
Mass (Da):93,294
Checksum:i4EA09B8F2B830917
GO
Isoform 3 (identifier: A3KGV1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MSASSSGGSP...PCGAPSVTVT → MKDRSSTPPL...LPKPSAASSQ

Show »
Length:825
Mass (Da):95,428
Checksum:i2C9CA2383DE85B81
GO
Isoform 4 (identifier: A3KGV1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MSASSSGGSP...PCGAPSVTVT → MKDRSSTPPL...LPKPSAASSQ
     281-281: E → EK

Show »
Length:826
Mass (Da):95,556
Checksum:i9C8D6973FDB5E2C9
GO
Isoform 5 (identifier: A3KGV1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MSASSSGGSP...PCGAPSVTVT → MKDRSSTPPL...LPKPSAASSQ
     638-657: IEHQGDKLEMAREKHQASQK → VRDWQKGSHELARAGARLPR
     658-830: Missing.

Show »
Length:652
Mass (Da):75,410
Checksum:i9545123A1A29B617
GO
Isoform 6 (identifier: A3KGV1-6) [UniParc]FASTAAdd to basket
Also known as: ODF2/2

The sequence of this isoform differs from the canonical sequence as follows:
     65-83: Missing.
     638-657: IEHQGDKLEMAREKHQASQK → VRDWQKGSHELARAGARLPR
     658-830: Missing.

Show »
Length:638
Mass (Da):73,389
Checksum:i23DC7851F0626B2E
GO
Isoform 7 (identifier: A3KGV1-7) [UniParc]FASTAAdd to basket
Also known as: ODF2/1

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     638-657: IEHQGDKLEMAREKHQASQK → VRDWQKGSHELARAGARLPR
     658-830: Missing.

Show »
Length:610
Mass (Da):70,765
Checksum:i6ED88AB7A191A70B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A3KGW0A3KGW0_MOUSE
Outer dense fiber protein 2
Odf2
701Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A3KGV3A3KGV3_MOUSE
Outer dense fiber protein 2
Odf2
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A3KGV2A3KGV2_MOUSE
Outer dense fiber protein 2
Odf2
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GXZ0V9GXZ0_MOUSE
Outer dense fiber protein 2
Odf2
680Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Y325F6Y325_MOUSE
Outer dense fiber protein 2
Odf2
271Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A3KGV9A3KGV9_MOUSE
Outer dense fiber protein 2
Odf2
657Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti349L → W in AAH57001 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0276711 – 47Missing in isoform 7. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_0276721 – 41MSASS…SVTVT → MKDRSSTPPLHVHVDENTPV HVHIKKLPKPSAASSQ in isoform 2, isoform 3, isoform 4 and isoform 5. 2 PublicationsAdd BLAST41
Alternative sequenceiVSP_02767365 – 83Missing in isoform 2 and isoform 6. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_027674281E → EK in isoform 4. 1 Publication1
Alternative sequenceiVSP_027675638 – 657IEHQG…QASQK → VRDWQKGSHELARAGARLPR in isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_027676658 – 830Missing in isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST173

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF000968 mRNA Translation: AAB65157.1
AF034105 mRNA Translation: AAB87525.1
AK143726 mRNA Translation: BAE25517.1
AK168415 mRNA Translation: BAE40330.1
AL928926 Genomic DNA No translation available.
BC057001 mRNA Translation: AAH57001.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS15861.1 [A3KGV1-6]
CCDS50555.1 [A3KGV1-4]
CCDS50556.1 [A3KGV1-3]
CCDS50557.1 [A3KGV1-5]
CCDS89461.1 [A3KGV1-1]
CCDS89462.1 [A3KGV1-2]

Protein sequence database of the Protein Information Resource

More...PIRi		T02298
T09400

NCBI Reference Sequences

More...RefSeqi		NP_001106684.1, NM_001113213.1 [A3KGV1-3]
NP_001106685.1, NM_001113214.1 [A3KGV1-5]
NP_001171130.1, NM_001177659.1 [A3KGV1-4]
NP_001171132.1, NM_001177661.1
NP_038643.1, NM_013615.3 [A3KGV1-6]
XP_017171778.1, XM_017316289.1
XP_017171779.1, XM_017316290.1 [A3KGV1-4]
XP_017171780.1, XM_017316291.1 [A3KGV1-4]
XP_017171781.1, XM_017316292.1 [A3KGV1-4]
XP_017171782.1, XM_017316293.1 [A3KGV1-3]
XP_017171793.1, XM_017316304.1 [A3KGV1-2]
XP_017171794.1, XM_017316305.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000028128; ENSMUSP00000028128; ENSMUSG00000026790 [A3KGV1-6]
ENSMUST00000046571; ENSMUSP00000049272; ENSMUSG00000026790 [A3KGV1-3]
ENSMUST00000113755; ENSMUSP00000109384; ENSMUSG00000026790 [A3KGV1-5]
ENSMUST00000113756; ENSMUSP00000109385; ENSMUSG00000026790 [A3KGV1-3]
ENSMUST00000113757; ENSMUSP00000109386; ENSMUSG00000026790 [A3KGV1-2]
ENSMUST00000113759; ENSMUSP00000109388; ENSMUSG00000026790 [A3KGV1-4]
ENSMUST00000113763; ENSMUSP00000109392; ENSMUSG00000026790 [A3KGV1-6]
ENSMUST00000113764; ENSMUSP00000109393; ENSMUSG00000026790 [A3KGV1-6]
ENSMUST00000113765; ENSMUSP00000109394; ENSMUSG00000026790 [A3KGV1-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		18286

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:18286

UCSC genome browser

More...UCSCi		uc008jaj.2, mouse [A3KGV1-5]
uc008jak.2, mouse [A3KGV1-3]
uc008jam.2, mouse [A3KGV1-6]
uc033hmh.1, mouse [A3KGV1-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000968 mRNA Translation: AAB65157.1
AF034105 mRNA Translation: AAB87525.1
AK143726 mRNA Translation: BAE25517.1
AK168415 mRNA Translation: BAE40330.1
AL928926 Genomic DNA No translation available.
BC057001 mRNA Translation: AAH57001.1
CCDSiCCDS15861.1 [A3KGV1-6]
CCDS50555.1 [A3KGV1-4]
CCDS50556.1 [A3KGV1-3]
CCDS50557.1 [A3KGV1-5]
CCDS89461.1 [A3KGV1-1]
CCDS89462.1 [A3KGV1-2]
PIRiT02298
T09400
RefSeqiNP_001106684.1, NM_001113213.1 [A3KGV1-3]
NP_001106685.1, NM_001113214.1 [A3KGV1-5]
NP_001171130.1, NM_001177659.1 [A3KGV1-4]
NP_001171132.1, NM_001177661.1
NP_038643.1, NM_013615.3 [A3KGV1-6]
XP_017171778.1, XM_017316289.1
XP_017171779.1, XM_017316290.1 [A3KGV1-4]
XP_017171780.1, XM_017316291.1 [A3KGV1-4]
XP_017171781.1, XM_017316292.1 [A3KGV1-4]
XP_017171782.1, XM_017316293.1 [A3KGV1-3]
XP_017171793.1, XM_017316304.1 [A3KGV1-2]
XP_017171794.1, XM_017316305.1

3D structure databases

SMRiA3KGV1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi201898, 5 interactors
IntActiA3KGV1, 3 interactors
STRINGi10090.ENSMUSP00000109388

PTM databases

iPTMnetiA3KGV1
PhosphoSitePlusiA3KGV1

2D gel databases

REPRODUCTION-2DPAGEiA3KGV1
IPI00130958

Proteomic databases

jPOSTiA3KGV1
MaxQBiA3KGV1
PaxDbiA3KGV1
PeptideAtlasiA3KGV1
PRIDEiA3KGV1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		976, 240 antibodies

Genome annotation databases

EnsembliENSMUST00000028128; ENSMUSP00000028128; ENSMUSG00000026790 [A3KGV1-6]
ENSMUST00000046571; ENSMUSP00000049272; ENSMUSG00000026790 [A3KGV1-3]
ENSMUST00000113755; ENSMUSP00000109384; ENSMUSG00000026790 [A3KGV1-5]
ENSMUST00000113756; ENSMUSP00000109385; ENSMUSG00000026790 [A3KGV1-3]
ENSMUST00000113757; ENSMUSP00000109386; ENSMUSG00000026790 [A3KGV1-2]
ENSMUST00000113759; ENSMUSP00000109388; ENSMUSG00000026790 [A3KGV1-4]
ENSMUST00000113763; ENSMUSP00000109392; ENSMUSG00000026790 [A3KGV1-6]
ENSMUST00000113764; ENSMUSP00000109393; ENSMUSG00000026790 [A3KGV1-6]
ENSMUST00000113765; ENSMUSP00000109394; ENSMUSG00000026790 [A3KGV1-1]
GeneIDi18286
KEGGimmu:18286
UCSCiuc008jaj.2, mouse [A3KGV1-5]
uc008jak.2, mouse [A3KGV1-3]
uc008jam.2, mouse [A3KGV1-6]
uc033hmh.1, mouse [A3KGV1-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4957
MGIiMGI:1098824, Odf2

Phylogenomic databases

eggNOGiENOG502QUXQ, Eukaryota
GeneTreeiENSGT00530000063497
HOGENOMiCLU_018326_0_0_1
InParanoidiA3KGV1
KOiK16479
OMAiKASYTNV
OrthoDBi328077at2759
PhylomeDBiA3KGV1
TreeFamiTF328605

Enzyme and pathway databases

ReactomeiR-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259, Loss of Nlp from mitotic centrosomes
R-MMU-380270, Recruitment of mitotic centrosome proteins and complexes
R-MMU-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-MMU-380320, Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912, Anchoring of the basal body to the plasma membrane
R-MMU-8854518, AURKA Activation by TPX2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		18286, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Odf2, mouse

Protein Ontology

More...PROi		PR:A3KGV1
RNActiA3KGV1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000026790, Expressed in testis and 307 other tissues
ExpressionAtlasiA3KGV1, baseline and differential
GenevisibleiA3KGV1, MM

Family and domain databases

InterProiView protein in InterPro
IPR026099, Odf2-rel
PANTHERiPTHR23162, PTHR23162, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiODFP2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A3KGV1
Secondary accession number(s): A3KGV5
, A3KGV6, O35135, O35496, Q3TH68, Q3UP80, Q6PGI6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 3, 2007
Last modified: August 12, 2020
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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