UniProtKB - A3KGV1 (ODFP2_MOUSE)
Outer dense fiber protein 2
Odf2
Functioni
GO - Molecular functioni
- Rab GTPase binding Source: MGI
- structural constituent of cytoskeleton Source: MGI
GO - Biological processi
- centriole-centriole cohesion Source: MGI
- cilium organization Source: MGI
- multicellular organism development Source: UniProtKB-KW
- protein localization Source: MGI
- regulation of cilium assembly Source: MGI
- spermatid development Source: Ensembl
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Spermatogenesis |
Enzyme and pathway databases
Reactomei | R-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition R-MMU-380259, Loss of Nlp from mitotic centrosomes R-MMU-380270, Recruitment of mitotic centrosome proteins and complexes R-MMU-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-MMU-380320, Recruitment of NuMA to mitotic centrosomes R-MMU-5620912, Anchoring of the basal body to the plasma membrane R-MMU-8854518, AURKA Activation by TPX2 |
Names & Taxonomyi
Protein namesi | Recommended name: Outer dense fiber protein 2Alternative name(s): 84 kDa outer dense fiber protein Cenexin Outer dense fiber of sperm tails protein 2 |
Gene namesi | Name:Odf2 Synonyms:Odf84 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1098824, Odf2 |
Subcellular locationi
Cytoskeleton
- centrosome 2 Publications
- centriole 1 Publication
- spindle pole 1 Publication
Other locations
Note: Localized at the microtubule organizing centers in interphase and spindle poles in mitosis. Localized at the distal/subdistal appendages of mother centrioles.1 Publication
Cytoskeleton
- centriole Source: MGI
- centrosome Source: UniProtKB
- ciliary basal body Source: MGI
- microtubule Source: UniProtKB-KW
- outer dense fiber Source: Ensembl
- spindle pole Source: UniProtKB-SubCell
Other locations
- centriolar subdistal appendage Source: MGI
- ciliary transition fiber Source: MGI
- cilium Source: MGI
- cytoplasm Source: UniProtKB-KW
- sperm flagellum Source: UniProtKB
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, MicrotubulePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299458 | 1 – 830 | Outer dense fiber protein 2Add BLAST | 830 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 73 | PhosphoserineBy similarity | 1 | |
Modified residuei | 74 | PhosphoserineBy similarity | 1 | |
Modified residuei | 92 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 95 | Phosphoserine; by TSSK41 Publication | 1 | |
Modified residuei | 106 | PhosphoserineBy similarity | 1 | |
Modified residuei | 109 | PhosphoserineBy similarity | 1 | |
Modified residuei | 110 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 115 | PhosphoserineBy similarity | 1 | |
Modified residuei | 129 | PhosphoserineBy similarity | 1 | |
Cross-linki | 138 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 139 | PhosphoserineBy similarity | 1 | |
Modified residuei | 231 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 261 | PhosphoserineBy similarity | 1 | |
Modified residuei | 632 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | A3KGV1 |
MaxQBi | A3KGV1 |
PaxDbi | A3KGV1 |
PeptideAtlasi | A3KGV1 |
PRIDEi | A3KGV1 |
2D gel databases
REPRODUCTION-2DPAGEi | A3KGV1 IPI00130958 |
PTM databases
iPTMneti | A3KGV1 |
PhosphoSitePlusi | A3KGV1 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000026790, Expressed in testis and 307 other tissues |
ExpressionAtlasi | A3KGV1, baseline and differential |
Genevisiblei | A3KGV1, MM |
Interactioni
Subunit structurei
Self-associates. Associates with microtubules and forms a fibrillar structure partially linked to the microtubule network.
Interacts via its C-terminus with PLK1 (By similarity).
Interacts with ODF1 (PubMed:9045620).
Interacts with MARK4; the interaction is required for localization of ODF2 to centrioles (By similarity).
Interacts with TSSK4 (PubMed:25361759, PubMed:26961893).
Interacts with AKNA (PubMed:30787442).
By similarity4 PublicationsGO - Molecular functioni
- Rab GTPase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 201898, 5 interactors |
IntActi | A3KGV1, 3 interactors |
STRINGi | 10090.ENSMUSP00000109388 |
Miscellaneous databases
RNActi | A3KGV1, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 144 – 217 | Sequence analysisAdd BLAST | 74 | |
Coiled coili | 245 – 423 | Sequence analysisAdd BLAST | 179 | |
Coiled coili | 461 – 798 | Sequence analysisAdd BLAST | 338 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QUXQ, Eukaryota |
GeneTreei | ENSGT00530000063497 |
HOGENOMi | CLU_018326_0_0_1 |
InParanoidi | A3KGV1 |
OMAi | KASYTNV |
OrthoDBi | 328077at2759 |
PhylomeDBi | A3KGV1 |
TreeFami | TF328605 |
Family and domain databases
InterProi | View protein in InterPro IPR026099, Odf2-rel |
PANTHERi | PTHR23162, PTHR23162, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSASSSGGSP RFPSCGKNGV TSLTQKKVLR TPCGAPSVTV TKSHKRGMKG
60 70 80 90 100
DTVNVRRSVR VKTKVPWMPP GKSSARHVGC KWENPPHCLE ITPPSSEKLV
110 120 130 140 150
SVMRLSDLST EDDDSGHCKM NRYDKKIDSL MNAVGCLKSE VKMQKGERQM
160 170 180 190 200
AKRFLEERKE ELEEVAHELA ETEHENTVLR HNIERIKEEK DFTMLQKKHL
210 220 230 240 250
QQEKECLMSK LVEAEMDGAA AAKQVMALKD TIGKLKTEKQ MTCTDINTLT
260 270 280 290 300
RQKELLLQKL STFEETNRTL RDLLREQHCK EDSERLMEQQ GTLLKRLAEA
310 320 330 340 350
DSEKARLLLL LQDKDKEVEE LLQEIQCEKA QAKTASELSK SMESMRGHLQ
360 370 380 390 400
AQLRCKEAEN SRLCMQIKNL ERSGNQHKAE VEAIMEQLKE LKQKGDRDKE
410 420 430 440 450
TLKKAIRAQK ERAEKSEEYA EQLHVQLADK DLYVAEALST LESWRSRYNQ
460 470 480 490 500
VVKDKGDLEL EIIVLNDRVT DLVNQQQSLE EKMREDRDSL VERLHRQTAE
510 520 530 540 550
YSAFKLENER LKASFAPMED KLNQAHLEVQ QLKASVKNYE GMIDNYKSQV
560 570 580 590 600
MKTRLEADEV AAQLERCDKE NKMLKDEMNK EIEAARRQFQ SQLADLQQLP
610 620 630 640 650
DILKITEAKL AECQDQLQGY ERKNIDLTAI ISDLRSRIEH QGDKLEMARE
660 670 680 690 700
KHQASQKENK QLSQKVDELE RKLEATSAQN VEFLQVIAKR EEAIHQAQLR
710 720 730 740 750
LEEKTRECGS LARQLESAIE DARRQVEQTK EQALSKERAA QSKILDLETQ
760 770 780 790 800
LSRTKTELGQ LRRTRDDADR RYQSRLQDLK DRLEQSESTN RSMQNYVQFL
810 820 830
KASYANVFGD APYTSSYLTS SPIRSRSPPA
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA3KGW0 | A3KGW0_MOUSE | Outer dense fiber protein 2 | Odf2 | 701 | Annotation score: | ||
A3KGV3 | A3KGV3_MOUSE | Outer dense fiber protein 2 | Odf2 | 138 | Annotation score: | ||
A3KGV2 | A3KGV2_MOUSE | Outer dense fiber protein 2 | Odf2 | 69 | Annotation score: | ||
V9GXZ0 | V9GXZ0_MOUSE | Outer dense fiber protein 2 | Odf2 | 680 | Annotation score: | ||
F6Y325 | F6Y325_MOUSE | Outer dense fiber protein 2 | Odf2 | 271 | Annotation score: | ||
A3KGV9 | A3KGV9_MOUSE | Outer dense fiber protein 2 | Odf2 | 657 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 349 | L → W in AAH57001 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027671 | 1 – 47 | Missing in isoform 7. 1 PublicationAdd BLAST | 47 | |
Alternative sequenceiVSP_027672 | 1 – 41 | MSASS…SVTVT → MKDRSSTPPLHVHVDENTPV HVHIKKLPKPSAASSQ in isoform 2, isoform 3, isoform 4 and isoform 5. 2 PublicationsAdd BLAST | 41 | |
Alternative sequenceiVSP_027673 | 65 – 83 | Missing in isoform 2 and isoform 6. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_027674 | 281 | E → EK in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_027675 | 638 – 657 | IEHQG…QASQK → VRDWQKGSHELARAGARLPR in isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST | 20 | |
Alternative sequenceiVSP_027676 | 658 – 830 | Missing in isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST | 173 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF000968 mRNA Translation: AAB65157.1 AF034105 mRNA Translation: AAB87525.1 AK143726 mRNA Translation: BAE25517.1 AK168415 mRNA Translation: BAE40330.1 AL928926 Genomic DNA No translation available. BC057001 mRNA Translation: AAH57001.1 |
CCDSi | CCDS15861.1 [A3KGV1-6] CCDS50555.1 [A3KGV1-4] CCDS50556.1 [A3KGV1-3] CCDS50557.1 [A3KGV1-5] CCDS89461.1 [A3KGV1-1] CCDS89462.1 [A3KGV1-2] |
PIRi | T02298 T09400 |
RefSeqi | NP_001106684.1, NM_001113213.1 [A3KGV1-3] NP_001106685.1, NM_001113214.1 [A3KGV1-5] NP_001171130.1, NM_001177659.1 [A3KGV1-4] NP_001171132.1, NM_001177661.1 NP_038643.1, NM_013615.3 [A3KGV1-6] XP_017171778.1, XM_017316289.1 XP_017171779.1, XM_017316290.1 [A3KGV1-4] XP_017171780.1, XM_017316291.1 [A3KGV1-4] XP_017171781.1, XM_017316292.1 [A3KGV1-4] XP_017171782.1, XM_017316293.1 [A3KGV1-3] XP_017171793.1, XM_017316304.1 [A3KGV1-2] XP_017171794.1, XM_017316305.1 |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF000968 mRNA Translation: AAB65157.1 AF034105 mRNA Translation: AAB87525.1 AK143726 mRNA Translation: BAE25517.1 AK168415 mRNA Translation: BAE40330.1 AL928926 Genomic DNA No translation available. BC057001 mRNA Translation: AAH57001.1 |
CCDSi | CCDS15861.1 [A3KGV1-6] CCDS50555.1 [A3KGV1-4] CCDS50556.1 [A3KGV1-3] CCDS50557.1 [A3KGV1-5] CCDS89461.1 [A3KGV1-1] CCDS89462.1 [A3KGV1-2] |
PIRi | T02298 T09400 |
RefSeqi | NP_001106684.1, NM_001113213.1 [A3KGV1-3] NP_001106685.1, NM_001113214.1 [A3KGV1-5] NP_001171130.1, NM_001177659.1 [A3KGV1-4] NP_001171132.1, NM_001177661.1 NP_038643.1, NM_013615.3 [A3KGV1-6] XP_017171778.1, XM_017316289.1 XP_017171779.1, XM_017316290.1 [A3KGV1-4] XP_017171780.1, XM_017316291.1 [A3KGV1-4] XP_017171781.1, XM_017316292.1 [A3KGV1-4] XP_017171782.1, XM_017316293.1 [A3KGV1-3] XP_017171793.1, XM_017316304.1 [A3KGV1-2] XP_017171794.1, XM_017316305.1 |
3D structure databases
SMRi | A3KGV1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201898, 5 interactors |
IntActi | A3KGV1, 3 interactors |
STRINGi | 10090.ENSMUSP00000109388 |
PTM databases
iPTMneti | A3KGV1 |
PhosphoSitePlusi | A3KGV1 |
2D gel databases
REPRODUCTION-2DPAGEi | A3KGV1 IPI00130958 |
Proteomic databases
jPOSTi | A3KGV1 |
MaxQBi | A3KGV1 |
PaxDbi | A3KGV1 |
PeptideAtlasi | A3KGV1 |
PRIDEi | A3KGV1 |
Protocols and materials databases
Antibodypediai | 976, 240 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 4957 |
MGIi | MGI:1098824, Odf2 |
Phylogenomic databases
eggNOGi | ENOG502QUXQ, Eukaryota |
GeneTreei | ENSGT00530000063497 |
HOGENOMi | CLU_018326_0_0_1 |
InParanoidi | A3KGV1 |
OMAi | KASYTNV |
OrthoDBi | 328077at2759 |
PhylomeDBi | A3KGV1 |
TreeFami | TF328605 |
Enzyme and pathway databases
Reactomei | R-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition R-MMU-380259, Loss of Nlp from mitotic centrosomes R-MMU-380270, Recruitment of mitotic centrosome proteins and complexes R-MMU-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-MMU-380320, Recruitment of NuMA to mitotic centrosomes R-MMU-5620912, Anchoring of the basal body to the plasma membrane R-MMU-8854518, AURKA Activation by TPX2 |
Miscellaneous databases
BioGRID-ORCSi | 18286, 0 hits in 17 CRISPR screens |
ChiTaRSi | Odf2, mouse |
PROi | PR:A3KGV1 |
RNActi | A3KGV1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026790, Expressed in testis and 307 other tissues |
ExpressionAtlasi | A3KGV1, baseline and differential |
Genevisiblei | A3KGV1, MM |
Family and domain databases
InterProi | View protein in InterPro IPR026099, Odf2-rel |
PANTHERi | PTHR23162, PTHR23162, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ODFP2_MOUSE | |
Accessioni | A3KGV1Primary (citable) accession number: A3KGV1 Secondary accession number(s): A3KGV5 Q6PGI6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | April 3, 2007 | |
Last modified: | December 2, 2020 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families