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Entry version 110 (05 Jun 2019)
Sequence version 1 (03 Apr 2007)
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Protein

Poly [ADP-ribose] polymerase

Gene

tnksb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase
LigandNADUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Poly [ADP-ribose] polymeraseUniRule annotation (EC:2.4.2.-UniRule annotation)
Short name:
PARPUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tnksbImported
Synonyms:LOC567533Imported, si:ch211-155m12.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-4865 tnksb

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000062897 Expressed in 27 organ(s), highest expression level in brain

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000085830

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini123 – 884ANK_REP_REGIONInterPro annotationAdd BLAST762
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati157 – 189ANKPROSITE-ProRule annotationAdd BLAST33
Repeati190 – 222ANKPROSITE-ProRule annotationAdd BLAST33
Repeati223 – 255ANKPROSITE-ProRule annotationAdd BLAST33
Repeati310 – 342ANKPROSITE-ProRule annotationAdd BLAST33
Repeati343 – 375ANKPROSITE-ProRule annotationAdd BLAST33
Repeati376 – 408ANKPROSITE-ProRule annotationAdd BLAST33
Repeati462 – 497ANKPROSITE-ProRule annotationAdd BLAST36
Repeati498 – 530ANKPROSITE-ProRule annotationAdd BLAST33
Repeati531 – 563ANKPROSITE-ProRule annotationAdd BLAST33
Repeati624 – 656ANKPROSITE-ProRule annotationAdd BLAST33
Repeati657 – 689ANKPROSITE-ProRule annotationAdd BLAST33
Repeati690 – 722ANKPROSITE-ProRule annotationAdd BLAST33
Repeati777 – 809ANKPROSITE-ProRule annotationAdd BLAST33
Repeati810 – 842ANKPROSITE-ProRule annotationAdd BLAST33
Repeati843 – 875ANKPROSITE-ProRule annotationAdd BLAST33
Domaini970 – 1029SAMInterPro annotationAdd BLAST60
Domaini1052 – 1257PARP catalyticInterPro annotationAdd BLAST206

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 116DisorderedSequence analysisAdd BLAST116

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 21PolarSequence analysisAdd BLAST21
Compositional biasi37 – 72PolarSequence analysisAdd BLAST36
Compositional biasi85 – 111PolarSequence analysisAdd BLAST27

Keywords - Domaini

ANK repeatPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4177 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156161

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000246964

KEGG Orthology (KO)

More...
KOi
K10799

Database of Orthologous Groups

More...
OrthoDBi
111565at2759

TreeFam database of animal gene trees

More...
TreeFami
TF326036

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 5 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit
1.25.40.20, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR028731 TANK1

The PANTHER Classification System

More...
PANTHERi
PTHR24180:SF3 PTHR24180:SF3, 5 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 4 hits
PF13606 Ank_3, 1 hit
PF00644 PARP, 1 hit
PF07647 SAM_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 18 hits
SM00454 SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit
SSF48403 SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 15 hits
PS51059 PARP_CATALYTIC, 1 hit
PS50105 SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A3KGU1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVSRRSSQH QQSSLQPSPR NAVIASPPPE SPSAIIPDSA SLLSPSATGA
60 70 80 90 100
AECGASTMES AAASSASASS PDRPAPVTAA AAGGPSVLGS SSCSSISSSA
110 120 130 140 150
TAGSQSPGSG AASPGEAVCG AGGAFRELFE ACRNGDVSRV KRLVDSVNVN
160 170 180 190 200
AKDMAGRKST PLHFAAGFGR KDVVEHLLQT GANVHSRDDG GLIPLHNACS
210 220 230 240 250
FGHAEVVSLL LCSGADPNAR DNWNYTPLHE AAIKGKIDVC IVLLQHGADP
260 270 280 290 300
NIRNTDGKSA LDLADPSAKT VLTGEYKKDE LLEAARSGNE EKLMALLTPL
310 320 330 340 350
NVNCHASDGR KSTPLHLAAG YNRVRIVQLL LQYGADVHAK DKGGLVPLHN
360 370 380 390 400
ACSYGHYEVT ELLLKHGACV NAMDLWQFTP LHEAASKNRV EVCSLLLSHG
410 420 430 440 450
ADPTLLNCHG KSAVDVAPTP ELKERLTYEF KGHSLLQAAR EADMAKVKKT
460 470 480 490 500
AQEIISFKHP HSHDSALHCA VASPHPKRKQ VTELLLRKGA NIHEKNKDFM
510 520 530 540 550
TPFHVAAERG HNDVLEVLQK HGAKVNAADT LGQTALHRAA LAGHIQTCRL
560 570 580 590 600
LLSYGADPSI VSLQGFTASQ MGNEAVQQIL NENVPPRNSD VDYRLLEAAK
610 620 630 640 650
AGDLDTVKQL CSPQNVNCRD LEGRHSTPLH FAAGYNRVAV VEYLLHHGAD
660 670 680 690 700
VHAKDKGGLV PLHNACSYGH YEVAELLVRH GASVNVADLW KFTPLHEAAA
710 720 730 740 750
KGKYEICKLL LKHGADPSKK NRDGNMALDM VKDGDTDIQD LLRGDAALLD
760 770 780 790 800
AAKKGCLARV QKLCSPENIN CRDTQGRNST PLHLAAGYNN LEVAEYLLEH
810 820 830 840 850
GADVNAQDKG GLIPLHNAAS YGHVDIAALL IKFNTCVNAT DKWAFTPLHE
860 870 880 890 900
AAQKGRTQLC ALLLAHGANP TMKNQEGQTA LDLATADDIR ALLMDAMPPD
910 920 930 940 950
ALPSCFKPQA TVLSAALISP ASTPSCLSAA SSIDNLAGPL CDGASGGAAG
960 970 980 990 1000
PADGASSTDR KEGDAVLDMN ISQFLKSLGL EHLRDIFERE QITLDVLADM
1010 1020 1030 1040 1050
GHEELKEIGI NAYGHRHKLI KGIERLLGGQ QGANPYLTFH CTNQGTVLID
1060 1070 1080 1090 1100
LAVDDKEFQS VEEEMQSTIR EHRDGGNAGG VFSRYNVIKI QKVVNKKLRE
1110 1120 1130 1140 1150
RYTHRQKEIA DENHNHHNER MLFHGSPFIN AIIHKGFDER HAYIGGMFGA
1160 1170 1180 1190 1200
GIYFAENSSK SNQYVYGIGG GTGCPTHKDR SCYLCHRQML FCRVTLGKSF
1210 1220 1230 1240 1250
LQFSAMKMAH APPGHHSVIG RPSVNGLAYA EYVIYRGEQA YPEYLITYQI
1260
MKPDSTPQSS TGAEQKS
Length:1,267
Mass (Da):135,830
Last modified:April 3, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC1AC136A7C96381
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4IYN3A0A0R4IYN3_DANRE
Poly [ADP-ribose] polymerase
tnksb si:ch211-155m12.3
1,274Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QG67A0A2R8QG67_DANRE
Poly [ADP-ribose] polymerase
tnksb
1,258Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL928901 Genomic DNA No translation available.
BC162262 mRNA Translation: AAI62262.1
BC162268 mRNA Translation: AAI62268.1

NCBI Reference Sequences

More...
RefSeqi
NP_001082884.1, NM_001089415.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000091397; ENSDARP00000085830; ENSDARG00000062897

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
567533

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:567533

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928901 Genomic DNA No translation available.
BC162262 mRNA Translation: AAI62262.1
BC162268 mRNA Translation: AAI62268.1
RefSeqiNP_001082884.1, NM_001089415.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000085830

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000091397; ENSDARP00000085830; ENSDARG00000062897
GeneIDi567533
KEGGidre:567533

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
567533
ZFINiZDB-GENE-030131-4865 tnksb

Phylogenomic databases

eggNOGiKOG4177 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000156161
HOGENOMiHOG000246964
KOiK10799
OrthoDBi111565at2759
TreeFamiTF326036

Gene expression databases

BgeeiENSDARG00000062897 Expressed in 27 organ(s), highest expression level in brain

Family and domain databases

CDDicd00204 ANK, 5 hits
Gene3Di1.10.150.50, 1 hit
1.25.40.20, 5 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR028731 TANK1
PANTHERiPTHR24180:SF3 PTHR24180:SF3, 5 hits
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 4 hits
PF13606 Ank_3, 1 hit
PF00644 PARP, 1 hit
PF07647 SAM_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 18 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48403 SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 15 hits
PS51059 PARP_CATALYTIC, 1 hit
PS50105 SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA3KGU1_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A3KGU1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: June 5, 2019
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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