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Entry version 99 (08 May 2019)
Sequence version 2 (15 May 2007)
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Protein

Ral GTPase-activating protein subunit alpha-2

Gene

Ralgapa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: MGI
  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ral GTPase-activating protein subunit alpha-2
Alternative name(s):
250 kDa substrate of Akt
Short name:
AS250
P220
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ralgapa2
Synonyms:Kiaa1272
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3036245 Ralgapa2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002869731 – 1872Ral GTPase-activating protein subunit alpha-2Add BLAST1872

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei373PhosphoserineCombined sources1
Modified residuei376PhosphoserineCombined sources1
Modified residuei379PhosphoserineCombined sources1
Modified residuei486PhosphoserineCombined sources1
Modified residuei696Phosphoserine; by PKBBy similarity1
Modified residuei715Phosphothreonine; by PKBBy similarity1
Modified residuei819PhosphoserineCombined sources1
Modified residuei820PhosphoserineCombined sources1
Modified residuei1592PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A3KGS3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A3KGS3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A3KGS3

PeptideAtlas

More...
PeptideAtlasi
A3KGS3

PRoteomics IDEntifications database

More...
PRIDEi
A3KGS3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A3KGS3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A3KGS3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly expressed in testis, pancreas, lung, thymus, brown fat, and white fat.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000037110 Expressed in 214 organ(s), highest expression level in urinary bladder urothelium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A3KGS3 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the heterodimeric RalGAP2 complex with RALGAPB. Heterodimerization is required for activity (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
232342, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000105613

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A3KGS3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1634 – 1842Rap-GAPPROSITE-ProRule annotationAdd BLAST209

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3686 Eukaryota
ENOG410XTIX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183139

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A3KGS3

Identification of Orthologs from Complete Genome Data

More...
OMAi
HMFFIEI

Database of Orthologous Groups

More...
OrthoDBi
157372at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A3KGS3

TreeFam database of animal gene trees

More...
TreeFami
TF324484

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
IPR027107 Tuberin/Ral-act_asu

The PANTHER Classification System

More...
PANTHERi
PTHR10063 PTHR10063, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02145 Rap_GAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111347 SSF111347, 1 hit
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50085 RAPGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A3KGS3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFSRRSHGDV KKSTQKVLDP KKDVLTRLKH LRALLDNVDA SDLKQFFETN
60 70 80 90 100
YSQIYFIFYE NFITLENSLK LKGNNKSQRE ELDSILFLFE KILQFLPERI
110 120 130 140 150
FFRWHYQSIG STLKKLLHTG NSIKIRCEGI RLFLLWLQAL QTNCAEEQVL
160 170 180 190 200
IFACLVPGFP AVLSSRGPCT LETLINPSPS IVDAKIYPEE ITPLLPAISG
210 220 230 240 250
EKIAEDQTCF FLQILLKYMV IQAASLEWKN KENQDTGFKF LFTLFRKYYL
260 270 280 290 300
PHLFPSFTKL TNIYKPVLEI PHLRPKPVYV TVTRDNETIY STKIPYMAAR
310 320 330 340 350
VVFIKWIVTF FLEKKYLTAT QNTKNGVDVL PKIIQTVGGG AIQEKVPELD
360 370 380 390 400
GAGSTEQDKS HSNSSTLSDR RLSNSSLCSI EEEHRTVYEM VQRILLSTRG
410 420 430 440 450
YVNFVNEVFR QAFLLPSCEI SVTRKVVQVY RKWILQNKPV FMEEPDKKDV
460 470 480 490 500
AQEDADKLGL SETDSKEASS ESSGHKRSSS WGRTYSFTSA MSRGCVTEED
510 520 530 540 550
NTNVKAGAQA MLQVFLTNAA NVFLLEPCAE VPMLLREQVD ASKAVLIIFR
560 570 580 590 600
RMIMELTMNQ KTWEQMLQIL LRITEAVMQK PKDKHVKDLF AQSLAGLLFR
610 620 630 640 650
TLIVAWIRAN LCVYISRELW DDFLRVLSSL TEWEELITEW SNIMDSLTAV
660 670 680 690 700
LARTVYGVEM TNLPLDKLSE QKEKKQRGKG CILEPQKGTA VGRSFSLSWR
710 720 730 740 750
SHPDVTEPMR FRSATTSGAP GVEKARNTVR QKATEVEEFQ QAESTAAADC
760 770 780 790 800
DYLVVGQQQV PRSSSTSDIT ERLYSDSSQG QKVEHSQNLS SSEPKSVQES
810 820 830 840 850
KGHVTHEHEG ITMLVRRSSS PAELELKDDL QQAHGRCRQR QTSESTGSDT
860 870 880 890 900
VVGYSNEAEL PVSPWQACEE DPDLSTPTDA VADSDARHWL QLSPTDASNL
910 920 930 940 950
TDSRECLADD CSIIAGGNLT GWHPDSAAVL WRRVLGILGD VNNIQSPKIH
960 970 980 990 1000
AKVFGYLYEL WYKLAKIRDN LAISLDNQSS PSPPLLIPPL RMFASWLFKA
1010 1020 1030 1040 1050
TTLPNEYKEG KLQAYKLICA MMTRRQDVLP NSDFLVHFYL VMHLGLTSED
1060 1070 1080 1090 1100
QDVLNTIIKN CSPRFFSLGL PGFSMLVGDF ITAAARVLST DMLAAPRSEA
1110 1120 1130 1140 1150
LTLLGSLVCF PNTYQEIPLL QSVPEVSDVV TGAEDVKHYL INILLKNATE
1160 1170 1180 1190 1200
EPNECARCIA ICSLGVWICE ELAQSASHPQ VKDAINVIGV TLKFPNKIVA
1210 1220 1230 1240 1250
QVACDVLQLL VSYWEKLQMF ETALPRKMAE ILVATIAFLL PSAEYSSVET
1260 1270 1280 1290 1300
DKKFIVSLLL CLLDWCMALP VSALLHPVST AVLEELHPSR APLLDYIYRV
1310 1320 1330 1340 1350
LHCCVCGSST YTQQSHYTLT LADLSSTDYD PFLPLANVRN SEPIQYHSSA
1360 1370 1380 1390 1400
DLGNLLTVEE EKKRRSVELI PLTARMVMAH LVNHLGHYPL SGGPAVLHSL
1410 1420 1430 1440 1450
VSENHDNAHV EGTELSSEVF RSPNLQLFVF NDSTLISYLQ TPAEGPAGGT
1460 1470 1480 1490 1500
SGGSLSDVRV IVRDISGKYS WDGKVLYGPL EGRLAPNGRN PSFQISGWHH
1510 1520 1530 1540 1550
HTCGPQKDLF NGEEGDDVLD KLLENIGHTS PECLLPSQLN LNEPSPTPCA
1560 1570 1580 1590 1600
MNWDQEKAIM EVILRQSAQE DEYVQRCNSD SSVTVTSQGQ PSPVEPRGPF
1610 1620 1630 1640 1650
YFCRLLLDDL GMNSWDRRKN FHLLKKNSKL LRELKNLDSR QCRETHKIAV
1660 1670 1680 1690 1700
FYIAEGQEDK CSILANERGS QAYEDFVAGL GWEVDLSTHC GFMGGLQRNG
1710 1720 1730 1740 1750
STGQTAPYYA TSTVEVIFHV STRMPSDSDD SLTKKLRHLG NDEVHIVWSE
1760 1770 1780 1790 1800
HSRDYRRGII PTAFGDVSII IYPMKNHMFF ITITKKPEVP FFGPLFDGAI
1810 1820 1830 1840 1850
VSGKLLPSLI CATCINASRA VKCLIPLYQS FYEERALYLE AIIQNHREVM
1860 1870
TFEDFAAQVF SPSPSYSVSG TD
Length:1,872
Mass (Da):210,288
Last modified:May 15, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCCB0AA23790D863A
GO
Isoform 2 (identifier: A3KGS3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1789-1807: VPFFGPLFDGAIVSGKLLP → LLLKIEKFHSLGPCSMERS
     1808-1872: Missing.

Show »
Length:1,807
Mass (Da):203,224
Checksum:i69100CE538A321E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQD7A0A0A0MQD7_MOUSE
Ral GTPase-activating protein subun...
Ralgapa2
1,910Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CGP0F7CGP0_MOUSE
Ral GTPase-activating protein subun...
Ralgapa2
1,567Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BPN8A0A2I3BPN8_MOUSE
Ral GTPase-activating protein subun...
Ralgapa2
1,957Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7AI67F7AI67_MOUSE
Ral GTPase-activating protein subun...
Ralgapa2
834Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC30146 differs from that shown. Probable cloning artifact leading to erroneous C-terminus.Curated
The sequence BAC30146 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAM46007 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM46125 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM46200 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti436Q → R in BAC30146 (PubMed:19468303).Curated1
Sequence conflicti447K → E in BAE34270 (PubMed:19468303).Curated1
Sequence conflicti1511N → H in AAH53994 (PubMed:15489334).Curated1
Sequence conflicti1727D → V in BAD32418 (PubMed:15368895).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0252511789 – 1807VPFFG…GKLLP → LLLKIEKFHSLGPCSMERS in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0252521808 – 1872Missing in isoform 2. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL845273, AL845430, AL935056 Genomic DNA Translation: CAM46125.1 Sequence problems.
AL845273, AL845430, AL935056 Genomic DNA Translation: CAX15311.1
AL845430, AL845273, AL935056 Genomic DNA Translation: CAM46200.1 Sequence problems.
AL845430, AL845273, AL935056 Genomic DNA Translation: CAX15398.1
AL935056, AL845273, AL845430 Genomic DNA Translation: CAM46007.1 Sequence problems.
AL935056, AL845273, AL845430 Genomic DNA Translation: CAX15696.1
AK038838 mRNA Translation: BAC30146.1 Sequence problems.
AK157932 mRNA Translation: BAE34270.1
BC053994 mRNA Translation: AAH53994.1
BC096528 mRNA Translation: AAH96528.1
AK173140 mRNA Translation: BAD32418.1

NCBI Reference Sequences

More...
RefSeqi
NP_001028520.2, NM_001033348.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000131824; ENSMUSP00000122039; ENSMUSG00000037110 [A3KGS3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
241694

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:241694

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845273, AL845430, AL935056 Genomic DNA Translation: CAM46125.1 Sequence problems.
AL845273, AL845430, AL935056 Genomic DNA Translation: CAX15311.1
AL845430, AL845273, AL935056 Genomic DNA Translation: CAM46200.1 Sequence problems.
AL845430, AL845273, AL935056 Genomic DNA Translation: CAX15398.1
AL935056, AL845273, AL845430 Genomic DNA Translation: CAM46007.1 Sequence problems.
AL935056, AL845273, AL845430 Genomic DNA Translation: CAX15696.1
AK038838 mRNA Translation: BAC30146.1 Sequence problems.
AK157932 mRNA Translation: BAE34270.1
BC053994 mRNA Translation: AAH53994.1
BC096528 mRNA Translation: AAH96528.1
AK173140 mRNA Translation: BAD32418.1
RefSeqiNP_001028520.2, NM_001033348.3

3D structure databases

SMRiA3KGS3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232342, 2 interactors
STRINGi10090.ENSMUSP00000105613

PTM databases

iPTMnetiA3KGS3
PhosphoSitePlusiA3KGS3

Proteomic databases

jPOSTiA3KGS3
MaxQBiA3KGS3
PaxDbiA3KGS3
PeptideAtlasiA3KGS3
PRIDEiA3KGS3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000131824; ENSMUSP00000122039; ENSMUSG00000037110 [A3KGS3-1]
GeneIDi241694
KEGGimmu:241694

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57186
MGIiMGI:3036245 Ralgapa2

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG3686 Eukaryota
ENOG410XTIX LUCA
GeneTreeiENSGT00950000183139
InParanoidiA3KGS3
OMAiHMFFIEI
OrthoDBi157372at2759
PhylomeDBiA3KGS3
TreeFamiTF324484

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ralgapa2 mouse

Protein Ontology

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PROi
PR:A3KGS3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000037110 Expressed in 214 organ(s), highest expression level in urinary bladder urothelium
ExpressionAtlasiA3KGS3 baseline and differential

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
IPR027107 Tuberin/Ral-act_asu
PANTHERiPTHR10063 PTHR10063, 1 hit
PfamiView protein in Pfam
PF02145 Rap_GAP, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
SSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50085 RAPGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGPA2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A3KGS3
Secondary accession number(s): A3KGS5
, B7ZCU9, Q3TZD9, Q4VA60, Q69ZM8, Q7TQL4, Q8BYP2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: May 8, 2019
This is version 99 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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