Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 86 (08 May 2019)
Sequence version 1 (05 Feb 2008)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

TBC1 domain family member 8B

Gene

Tbc1d8b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a GTPase-activating protein for Rab family protein(s).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei533Arginine fingerBy similarity1
Sitei572Glutamine fingerBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-432722 Golgi Associated Vesicle Biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TBC1 domain family member 8B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tbc1d8b
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918101 Tbc1d8b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003371841 – 1114TBC1 domain family member 8BAdd BLAST1114

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A3KGB4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A3KGB4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A3KGB4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A3KGB4

PeptideAtlas

More...
PeptideAtlasi
A3KGB4

PRoteomics IDEntifications database

More...
PRIDEi
A3KGB4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A3KGB4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A3KGB4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000042473 Expressed in 219 organ(s), highest expression level in pituitary gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A3KGB4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000094036

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A3KGB4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini145 – 212GRAM 1Add BLAST68
Domaini285 – 353GRAM 2Add BLAST69
Domaini486 – 673Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST188
Domaini857 – 892EF-handPROSITE-ProRule annotationAdd BLAST36

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4347 Eukaryota
COG5210 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159451

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000276905

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A3KGB4

KEGG Orthology (KO)

More...
KOi
K19951

Identification of Orthologs from Complete Genome Data

More...
OMAi
QRECSKT

Database of Orthologous Groups

More...
OrthoDBi
450360at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313145

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13350 PH-GRAM1_TBC1D8B, 1 hit
cd13352 PH-GRAM2_TBC1D8B, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR036012 TBC1D8B_PH-GRAM1
IPR036015 TBC1D8B_PH-GRAM2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02893 GRAM, 2 hits
PF00566 RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00568 GRAM, 2 hits
SM00164 TBC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit
SSF47923 SSF47923, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS50086 TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A3KGB4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWLKPEEVLL KNALKLWLME RSNEYFVLQR RRGYGEEGGG GLTGLLVGTL
60 70 80 90 100
DSVLDSTAKV APFRILHQTP DSQVYLSIAC GANREEITKH WDWLEQNIMK
110 120 130 140 150
TLSVFDSNED ITNFVQGKIR GLIAEEGKQS FAKEDDPEKF REALLKFEKS
160 170 180 190 200
FGLPEQEKLV TYYSCSYWRG RVPCQGWLYL STNFLSFYSF LLGSEIKLII
210 220 230 240 250
SWDAISKLEK TSTVILTESI HVCSQGENHY FSMFLHINET YLLMEQLANY
260 270 280 290 300
AIKRLFDKET FDNDPVLDDP LQITKRGLEY RAHSEQFKAF FRLPKEETLK
310 320 330 340 350
EVHECFLWVP FSHFSSHGKM CISENYICFA SQDGNLCSVI IPLREVLAID
360 370 380 390 400
KTDDSNRSVI ISIKGKTAFR FSELKDFEQL VAKLRLKCRA ASTQDDVSTE
410 420 430 440 450
VAVSSDSTGP SENFEEQPLT CPKECSKTVN TEALMTVFHP QNLENLDSKM
460 470 480 490 500
LKEKMKEQSW NILFSECGRG VSMFRTKKTR DLVVRGIPET LRGELWMLFS
510 520 530 540 550
GAVNDMATNP GYYAEVVEQS LGTSNLATEE IERDLRRSLP EHPAFQSDTG
560 570 580 590 600
ISALRRVLTA YAYRNPKIGY CQAMNILTSV LLLYAKEEEA FWLLVAVCER
610 620 630 640 650
MLPDYFNRRI IGALVDQAVF EELIRDHLPQ LTDHMTDMTF FSSVSLSWFL
660 670 680 690 700
TLFISVLPIE SAVNVVDCFF YDGIKAILQL GLAILDYNLD KLLTCKDDAE
710 720 730 740 750
AVTALNRFFD NVINKDSPLP SNVQQGSNIS NEKSDHTKVD ITDLIKESNE
760 770 780 790 800
KYGSIRYEDI HSMRCRNRLY VIQTLEETTK QNVLRVVSQD VKMSLQELDE
810 820 830 840 850
LYVIFKKELF ISCYWYLSCP GLKHHDPSLP YLEQYQIDCQ QFRVLYHLLS
860 870 880 890 900
PWAHSANRDS LALWTFRLLD ENSDCLINFK EFSSAIDIMY NGSFTDKLKL
910 920 930 940 950
LFKLHIPPAY TEVMSKTSSK GDELSTEELL YFSQLQVSKP ADEKETESGR
960 970 980 990 1000
NSPEKGKGKI DIQAYLSQWQ DELLKKEETI KDLPRMNQSQ FIQFSKTLYN
1010 1020 1030 1040 1050
LFHEDPEEES LYQAIAIVTN LLLRMEEVGR KLHSPASSAS TARDSGPSEG
1060 1070 1080 1090 1100
NAESSVKKDL PSPREEHQWS FAFEQILASL LNEPALVRFF ERPLDLKAKL
1110
ENAKSSQLRS RTKM
Length:1,114
Mass (Da):127,893
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38EFAD9B55420628
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL672243 Genomic DNA No translation available.
AL731648 Genomic DNA No translation available.
BC147581 mRNA Translation: AAI47582.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41146.1

NCBI Reference Sequences

More...
RefSeqi
NP_001074968.1, NM_001081499.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000096313; ENSMUSP00000094036; ENSMUSG00000042473

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
245638

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:245638

UCSC genome browser

More...
UCSCi
uc009ukj.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672243 Genomic DNA No translation available.
AL731648 Genomic DNA No translation available.
BC147581 mRNA Translation: AAI47582.1
CCDSiCCDS41146.1
RefSeqiNP_001074968.1, NM_001081499.2

3D structure databases

SMRiA3KGB4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094036

PTM databases

iPTMnetiA3KGB4
PhosphoSitePlusiA3KGB4

Proteomic databases

EPDiA3KGB4
jPOSTiA3KGB4
MaxQBiA3KGB4
PaxDbiA3KGB4
PeptideAtlasiA3KGB4
PRIDEiA3KGB4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096313; ENSMUSP00000094036; ENSMUSG00000042473
GeneIDi245638
KEGGimmu:245638
UCSCiuc009ukj.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54885
MGIiMGI:1918101 Tbc1d8b

Phylogenomic databases

eggNOGiKOG4347 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00940000159451
HOGENOMiHOG000276905
InParanoidiA3KGB4
KOiK19951
OMAiQRECSKT
OrthoDBi450360at2759
TreeFamiTF313145

Enzyme and pathway databases

ReactomeiR-MMU-432722 Golgi Associated Vesicle Biogenesis

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A3KGB4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000042473 Expressed in 219 organ(s), highest expression level in pituitary gland
GenevisibleiA3KGB4 MM

Family and domain databases

CDDicd13350 PH-GRAM1_TBC1D8B, 1 hit
cd13352 PH-GRAM2_TBC1D8B, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR036012 TBC1D8B_PH-GRAM1
IPR036015 TBC1D8B_PH-GRAM2
PfamiView protein in Pfam
PF02893 GRAM, 2 hits
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 2 hits
SM00164 TBC, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS50086 TBC_RABGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBC8B_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A3KGB4
Secondary accession number(s): B9EJW4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 8, 2019
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again