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Entry version 89 (16 Jan 2019)
Sequence version 1 (03 Apr 2007)
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Protein

Peptidase M20 domain-containing protein 2

Gene

Pm20d2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • dipeptidase activity Source: MGI

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptidase M20 domain-containing protein 2
Alternative name(s):
Aminoacylase-1-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pm20d2
Synonyms:Acy1l2, Gm424
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2685270 Pm20d2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002863411 – 431Peptidase M20 domain-containing protein 2Add BLAST431

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A3KG59

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A3KG59

PeptideAtlas

More...
PeptideAtlasi
A3KG59

PRoteomics IDEntifications database

More...
PRIDEi
A3KG59

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A3KG59

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A3KG59

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000054659 Expressed in 18 organ(s), highest expression level in heart

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000095783

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A3KG59

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A3KG59

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M20A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFYV Eukaryota
COG1473 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003365

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000251261

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG095598

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A3KG59

Identification of Orthologs from Complete Genome Data

More...
OMAi
HYAITDT

Database of Orthologous Groups

More...
OrthoDBi
455218at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A3KG59

TreeFam database of animal gene trees

More...
TreeFami
TF332656

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05672 M20_ACY1L2_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017439 Amidohydrolase
IPR036264 Bact_exopeptidase_dim_dom
IPR017144 Pept_M20A_amidohydro_pred
IPR002933 Peptidase_M20
IPR011650 Peptidase_M20_dimer

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07687 M20_dimer, 1 hit
PF01546 Peptidase_M20, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037226 Amidohydrolase_ACY1L2_prd, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55031 SSF55031, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01891 amidohydrolases, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A3KG59-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPVVERPAE PGTSSAAELE LLKRRAAERI DEAAERLGAL SRAIWSAPEL
60 70 80 90 100
AYEEHRAHGE LTRFFECEPP AASWAVQPHF GLPTAFRAEW APPESAAGPR
110 120 130 140 150
ALQVAFLCEY DALPALGHAC GHNLIAEVGV AAALGLRAAL ESIAAPPPVK
160 170 180 190 200
VIVLGTPAEE DGGGKIDLIE AGAFENLDVV FMAHPSQENA AYLPDVAEHD
210 220 230 240 250
VTVKYYGKAS HAAAYPWEGV NALDAAVLAY TNLSVLRQQM KPTWRVHGII
260 270 280 290 300
KNGGVKPNII PSYSELVYYF RAPSMKELQV LTKKAEDCFR AAALATGCTV
310 320 330 340 350
DIESEAHDYY NVIPNKTLCS AYTENGKKLG MEFISEDAVL NGPSGSTDFG
360 370 380 390 400
NVSFVVPGIH PYFYIGTDAL NHTEQYTEAA GSQAAQLYTL RTAKALAMTA
410 420 430
LDVIFKPALL EGVRKEFKCK LQEEQLLNTA A
Length:431
Mass (Da):46,482
Last modified:April 3, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF2AD1380593F283
GO
Isoform 2 (identifier: A3KG59-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-305: DIESE → RAFQN
     306-431: Missing.

Note: No experimental confirmation available.
Show »
Length:305
Mass (Da):32,775
Checksum:i71DDEBEFF4610529
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti175E → K in BAE26351 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_025030301 – 305DIESE → RAFQN in isoform 2. 1 Publication5
Alternative sequenceiVSP_025031306 – 431Missing in isoform 2. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK145296 mRNA Translation: BAE26351.1
AL670464 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS51136.1 [A3KG59-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001030039.2, NM_001034867.2 [A3KG59-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.372465
Mm.484150

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000098181; ENSMUSP00000095783; ENSMUSG00000054659 [A3KG59-1]
ENSMUST00000119167; ENSMUSP00000113669; ENSMUSG00000054659 [A3KG59-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
242377

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:242377

UCSC genome browser

More...
UCSCi
uc008sfs.1 mouse [A3KG59-2]
uc012dbj.2 mouse [A3KG59-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145296 mRNA Translation: BAE26351.1
AL670464 Genomic DNA No translation available.
CCDSiCCDS51136.1 [A3KG59-1]
RefSeqiNP_001030039.2, NM_001034867.2 [A3KG59-1]
UniGeneiMm.372465
Mm.484150

3D structure databases

ProteinModelPortaliA3KG59
SMRiA3KG59
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095783

PTM databases

iPTMnetiA3KG59
PhosphoSitePlusiA3KG59

Proteomic databases

MaxQBiA3KG59
PaxDbiA3KG59
PeptideAtlasiA3KG59
PRIDEiA3KG59

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098181; ENSMUSP00000095783; ENSMUSG00000054659 [A3KG59-1]
ENSMUST00000119167; ENSMUSP00000113669; ENSMUSG00000054659 [A3KG59-2]
GeneIDi242377
KEGGimmu:242377
UCSCiuc008sfs.1 mouse [A3KG59-2]
uc012dbj.2 mouse [A3KG59-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
135293
MGIiMGI:2685270 Pm20d2

Phylogenomic databases

eggNOGiENOG410IFYV Eukaryota
COG1473 LUCA
GeneTreeiENSGT00390000003365
HOGENOMiHOG000251261
HOVERGENiHBG095598
InParanoidiA3KG59
OMAiHYAITDT
OrthoDBi455218at2759
PhylomeDBiA3KG59
TreeFamiTF332656

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A3KG59

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000054659 Expressed in 18 organ(s), highest expression level in heart

Family and domain databases

CDDicd05672 M20_ACY1L2_like, 1 hit
InterProiView protein in InterPro
IPR017439 Amidohydrolase
IPR036264 Bact_exopeptidase_dim_dom
IPR017144 Pept_M20A_amidohydro_pred
IPR002933 Peptidase_M20
IPR011650 Peptidase_M20_dimer
PfamiView protein in Pfam
PF07687 M20_dimer, 1 hit
PF01546 Peptidase_M20, 1 hit
PIRSFiPIRSF037226 Amidohydrolase_ACY1L2_prd, 1 hit
SUPFAMiSSF55031 SSF55031, 1 hit
TIGRFAMsiTIGR01891 amidohydrolases, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP20D2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A3KG59
Secondary accession number(s): Q3ULU7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: April 3, 2007
Last modified: January 16, 2019
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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