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Protein

Cytosolic 5'-nucleotidase 1A

Gene

Nt5c1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia (By similarity).By similarity

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.

Cofactori

Mg2+By similarity

Activity regulationi

Activated by ADP.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei208NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

  • adenosine metabolic process Source: MGI
  • nucleotide metabolic process Source: UniProtKB-KW
  • purine nucleoside monophosphate catabolic process Source: MGI

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-73621 Pyrimidine catabolism
R-MMU-74259 Purine catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic 5'-nucleotidase 1A (EC:3.1.3.5)
Short name:
cN1A
Alternative name(s):
Cytosolic 5'-nucleotidase IA
Short name:
cN-IA
Gene namesi
Name:Nt5c1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2155700 Nt5c1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049301 – 365Cytosolic 5'-nucleotidase 1AAdd BLAST365

Proteomic databases

MaxQBiA3KFX0
PaxDbiA3KFX0
PeptideAtlasiA3KFX0
PRIDEiA3KFX0

PTM databases

iPTMnetiA3KFX0
PhosphoSitePlusiA3KFX0

Expressioni

Gene expression databases

BgeeiENSMUSG00000054958 Expressed in 16 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_NT5C1A

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069422

Structurei

3D structure databases

ProteinModelPortaliA3KFX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 5'-nucleotidase type 3 family.Curated

Phylogenomic databases

eggNOGiENOG410IE01 Eukaryota
ENOG410XPRD LUCA
GeneTreeiENSGT00390000017767
HOGENOMiHOG000243802
HOVERGENiHBG101325
InParanoidiA3KFX0
KOiK01081
OMAiQLDHENE
OrthoDBiEOG091G0EZE
TreeFamiTF329831

Family and domain databases

InterProiView protein in InterPro
IPR010394 5-nucleotidase
PANTHERiPTHR31367 PTHR31367, 1 hit
PfamiView protein in Pfam
PF06189 5-nucleotidase, 1 hit

Sequencei

Sequence statusi: Complete.

A3KFX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGQPREAR EPGPGAETAA VPRWEEAKTF YDNLSSKKKP KSPKPQNAVT
60 70 80 90 100
IAVSSRALFR MDEEQRIYTE QGVEEYVRYQ LEHENEPFSP GPAFPFVKAL
110 120 130 140 150
EAVNKRLREL YPDSEDIFDI VLMTNNHAQV GVRLINSINH YDLFIERFCM
160 170 180 190 200
TGGNSPICYL KAYHTNLYLS ADADKVREAI DEGIAAATIF SPSRDVVVSQ
210 220 230 240 250
SQLRVAFDGD AVLFSDESER IVKAHGLDRF FEHEKAHENK PLAQGPLKGF
260 270 280 290 300
LEALGRLQKK FYSKGLRLEC PIRTYLVTAR SAASSGARAL KTLRSWGLET
310 320 330 340 350
DEALFLAGAP KGPLLEKIRP HIFFDDQMFH VAGAQEMGTV AAHVPYGVAQ
360
NPRRAAAAKQ SLGAQ
Length:365
Mass (Da):40,678
Last modified:April 3, 2007 - v1
Checksum:i10DBCBE793C69D64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606934 Genomic DNA No translation available.
CH466552 Genomic DNA Translation: EDL30387.1
BC147308 mRNA Translation: AAI47309.1
BC147309 mRNA Translation: AAI47310.1
BC147730 mRNA Translation: AAI47731.1
BC147733 mRNA Translation: AAI47734.1
CCDSiCCDS38871.1
RefSeqiNP_001078971.1, NM_001085502.1
UniGeneiMm.354635

Genome annotation databases

EnsembliENSMUST00000068262; ENSMUSP00000069422; ENSMUSG00000054958
GeneIDi230718
KEGGimmu:230718
UCSCiuc008uoy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606934 Genomic DNA No translation available.
CH466552 Genomic DNA Translation: EDL30387.1
BC147308 mRNA Translation: AAI47309.1
BC147309 mRNA Translation: AAI47310.1
BC147730 mRNA Translation: AAI47731.1
BC147733 mRNA Translation: AAI47734.1
CCDSiCCDS38871.1
RefSeqiNP_001078971.1, NM_001085502.1
UniGeneiMm.354635

3D structure databases

ProteinModelPortaliA3KFX0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069422

PTM databases

iPTMnetiA3KFX0
PhosphoSitePlusiA3KFX0

Proteomic databases

MaxQBiA3KFX0
PaxDbiA3KFX0
PeptideAtlasiA3KFX0
PRIDEiA3KFX0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068262; ENSMUSP00000069422; ENSMUSG00000054958
GeneIDi230718
KEGGimmu:230718
UCSCiuc008uoy.1 mouse

Organism-specific databases

CTDi84618
MGIiMGI:2155700 Nt5c1a

Phylogenomic databases

eggNOGiENOG410IE01 Eukaryota
ENOG410XPRD LUCA
GeneTreeiENSGT00390000017767
HOGENOMiHOG000243802
HOVERGENiHBG101325
InParanoidiA3KFX0
KOiK01081
OMAiQLDHENE
OrthoDBiEOG091G0EZE
TreeFamiTF329831

Enzyme and pathway databases

ReactomeiR-MMU-73621 Pyrimidine catabolism
R-MMU-74259 Purine catabolism

Miscellaneous databases

PROiPR:A3KFX0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054958 Expressed in 16 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_NT5C1A

Family and domain databases

InterProiView protein in InterPro
IPR010394 5-nucleotidase
PANTHERiPTHR31367 PTHR31367, 1 hit
PfamiView protein in Pfam
PF06189 5-nucleotidase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei5NT1A_MOUSE
AccessioniPrimary (citable) accession number: A3KFX0
Secondary accession number(s): B2RVQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: April 3, 2007
Last modified: November 7, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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