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Protein

Olfactory receptor 2M5

Gene

OR2M5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2M5
Gene namesi
Name:OR2M5
Synonyms:OR2M5P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162727.3
HGNCiHGNC:19576 OR2M5
neXtProtiNX_A3KFT3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 311CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134871998

Polymorphism and mutation databases

BioMutaiOR2M5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002937191 – 312Olfactory receptor 2M5Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA3KFT3
PRIDEiA3KFT3
ProteomicsDBi565

Expressioni

Gene expression databases

BgeeiENSG00000162727
CleanExiHS_OR2M5

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355432

Structurei

3D structure databases

ProteinModelPortaliA3KFT3
SMRiA3KFT3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKZY Eukaryota
ENOG41115SC LUCA
GeneTreeiENSGT00760000118850
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiA3KFT3
KOiK04257
OMAiWILGSMD
OrthoDBiEOG091G0CY3
PhylomeDBiA3KFT3
TreeFamiTF337295

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

A3KFT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWENQTFNS DFILLGIFNH SPTHTFLFFL VLAIFSVAFM GNSVMVLLIY
60 70 80 90 100
LDTQLHTPMY FLLSQLFLMD LMLICSTVPK MAFNYLSGSK SISMAGCATQ
110 120 130 140 150
IFFYVSLLGS ECFLLAVMSY DRYIAICHPL RYTNLMRPKI CGLMTAFSWI
160 170 180 190 200
LGSMDAIIDA VATFSFSYCG SREIAHFFCD FPSLLILSCN DTSIFEKVLF
210 220 230 240 250
ICCIVMIVFP VAIIIASYAR VILAVIHMGS GEGRRKAFTT CSSHLMVVGM
260 270 280 290 300
YYGAGLFMYI RPTSDRSPMQ DKLVSVFYTI LTPMLNPLIY SLRNKEVTRA
310
LRKVLGKGKC GE
Length:312
Mass (Da):35,112
Last modified:April 3, 2007 - v1
Checksum:iEDA9160368F2D2CB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_064739244H → N Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592313 Genomic DNA No translation available.
CCDSiCCDS31105.1
RefSeqiNP_001004690.1, NM_001004690.1
UniGeneiHs.553580

Genome annotation databases

EnsembliENST00000366476; ENSP00000355432; ENSG00000162727
GeneIDi127059
KEGGihsa:127059
UCSCiuc010pze.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR2M5_HUMAN
AccessioniPrimary (citable) accession number: A3KFT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: April 3, 2007
Last modified: June 20, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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