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Entry version 105 (16 Jan 2019)
Sequence version 1 (03 Apr 2007)
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Protein

Chromodomain-helicase-DNA-binding protein 6

Gene

Chd6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi485 – 492ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 6 (EC:3.6.4.12)
Short name:
CHD-6
Alternative name(s):
ATP-dependent helicase CHD6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Chd6
Synonyms:Kiaa1335
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918639 Chd6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice with targeted deletion of exon 12 lacking part of the Helicase ATP-binding domain are born in normal Mendelian ratios and are viable. They are fertile and exhibit no obvious morphological or histological difference. However, they display a coordination deficiency which is not due to muscle weakness or bradykinesia.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004293531 – 2711Chromodomain-helicase-DNA-binding protein 6Add BLAST2711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1865PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A3KFM7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A3KFM7

PeptideAtlas

More...
PeptideAtlasi
A3KFM7

PRoteomics IDEntifications database

More...
PRIDEi
A3KFM7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A3KFM7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A3KFM7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000057133 Expressed in 263 organ(s), highest expression level in substantia nigra

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A3KFM7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A3KFM7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NFE2L2; involved in activation of the transcription.By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A3KFM7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000042291

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A3KFM7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A3KFM7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini291 – 342Chromo 1PROSITE-ProRule annotationAdd BLAST52
Domaini374 – 438Chromo 2PROSITE-ProRule annotationAdd BLAST65
Domaini472 – 646Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST175
Domaini786 – 955Helicase C-terminalPROSITE-ProRule annotationAdd BLAST170
Domaini1448 – 1502Myb-likeAdd BLAST55

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 746Required for DNA-dependent ATPase activityBy similarityAdd BLAST746

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi597 – 600DEAH box4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0383 Eukaryota
COG0553 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158986

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000246942

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107676

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A3KFM7

KEGG Orthology (KO)

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KOi
K14436

Identification of Orthologs from Complete Genome Data

More...
OMAi
TIYQRCN

Database of Orthologous Groups

More...
OrthoDBi
7181at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A3KFM7

TreeFam database of animal gene trees

More...
TreeFami
TF313572

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00024 CHROMO, 2 hits
cd00079 HELICc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006576 BRK_domain
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00385 Chromo, 2 hits
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00592 BRK, 1 hit
SM00298 CHROMO, 2 hits
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF54160 SSF54160, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50013 CHROMO_2, 1 hit
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A3KFM7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKMKIQKKEK QLSKLRALNH SPMSDASVNF DYKSPSPFDC SPDQGENIEE
60 70 80 90 100
AANHCLPHKN LYTTEEEADT LFSRKLTSHN GMEDSGGRGT GVKKKRKKKE
110 120 130 140 150
PGEQEGTKGS KDREPKPKRK REPKEPKEPR RAKEPKRAKE PKETKQKDGV
160 170 180 190 200
KKPRKHREAS GTKEGKEKRS CTDYGSRTKS KKASREQGPT PVERKKKGKR
210 220 230 240 250
KNETTVESLE LDHSLPNPSL QSPEEPSESA DSQKRRSGRQ VKRRKYNEDL
260 270 280 290 300
DFKVVDDDGE TIAVLGAGRT SALSASTLAW QAEEPPEDDA NIIEKILASK
310 320 330 340 350
TVQEVHPGEP PFDLELFYVK YRNFSYLHCK WATMEELEKD PRIAQKIKRF
360 370 380 390 400
RNKQAQMKHI FTEPDEDLFN PDYIEIDRIL EVAHTKDAET GEEVTHYLVK
410 420 430 440 450
WCSLPYEEST WELEEDVDPA KVKEFESLQI LPEVKHVERP ASDAWQKLET
460 470 480 490 500
SREYRNSNRL REYQLEGMNW LLFNWYNRKN CILADEMGLG KTIQSIAFLS
510 520 530 540 550
EIFVRGIHGP FLIIAPLSTI TNWEREFRTW TEMNAIVYHG SQISRQMIQQ
560 570 580 590 600
YEMVYRDAQG NPLSGVFKFH VVITTFEMIL ADCPELKKIH WSCVIIDEAH
610 620 630 640 650
RLKNRNCKLL EGLKLMALEH KVLLTGTPLQ NSVEELFSLL NFLEPSQFPS
660 670 680 690 700
ETAFLEEFGD LKTEEQVKKL QSILKPMMLR RLKDDVEKNL APKQETIIEV
710 720 730 740 750
ELTNIQKKYY RAILEKNFSF LTKGANQHNM PNLINTMMEL RKCCNHPYLI
760 770 780 790 800
NGAEEKILED FRKAHSSEAS DFQLQAMIQA AGKLVLIDKL LPKLIAGGHK
810 820 830 840 850
VLIFSQMVRC LDILEDYLIQ RRYTYERIDG RVRGNLRQAA IDRFCKPDSD
860 870 880 890 900
RFVFLLCTRA GGLGINLTAA DTCIIFDSDW NPQNDLQAQA RCHRIGQSKA
910 920 930 940 950
VKVYRLITRN SYEREMFDKA SLKLGLDKAI LQDINRKGST NGVQQLSKME
960 970 980 990 1000
VEDLLRKGAY GALMDEEDEG SKFCEEDIDQ ILQRRTHTIT IQSEGKGSTF
1010 1020 1030 1040 1050
AKASFVASGN RTDISLDDPN FWQKWAKIAE LDTEANNEKE SLVIDRPRVR
1060 1070 1080 1090 1100
KQTKHYNSFE EDELMEFSEL DSDSDERPTR SRRLSDRARR YLRAECFRVE
1110 1120 1130 1140 1150
KNLLIFGWGR WKDILTHGRF KWPLNEKDME MICRALLVYC VKHYKGDEKI
1160 1170 1180 1190 1200
KSFIWELITP SKDGQVQTLQ NHSGLSAPVP RGRKGKKTKN QLLLPELKNA
1210 1220 1230 1240 1250
DWLATCNPEV VLHDDGYKKH LKQHCNKVLL RVRMLYYLKA EILGEAADKA
1260 1270 1280 1290 1300
FEGTPARELD VLLPDIDYVE IPVDWWDAEA DKSLLIGVFK HGYERYNAMR
1310 1320 1330 1340 1350
ADPALCFLEK VGMPDEKSLS AEQGVTDGTS DIPERGNIDK EDSAEDKLDG
1360 1370 1380 1390 1400
LQKQTASPSD GSDGIFGEKK DDSQAAQDGS DPDKSPWPVS SALTARLRRL
1410 1420 1430 1440 1450
VTIYQRCNRK ELCRPEILGP GNQGYWVQEE VFRRTSEMDL INKEAQKRWT
1460 1470 1480 1490 1500
RREQADFYRT VSSFGVVYDQ EKKAFDWTQF RIISRLDKKS DESLEHYFYS
1510 1520 1530 1540 1550
FVAMCRNVCR LPAWKDDGPP DASIYVEPIT EERAAKTLYR IELLRKVREQ
1560 1570 1580 1590 1600
VLMCPQLHER LQLCRPSLYL PVWWECGKHD RDLLIGTAKH GLNRTDYYIM
1610 1620 1630 1640 1650
NDPQLSFLDA YRNYAQHKRT DTQAPGSLCC LYQSNSKLYE SLTYTPVSRT
1660 1670 1680 1690 1700
SESLESEPEN LMRMESRDDH LCLPEGGLPD ITCENFVSKV QEVISLDHDE
1710 1720 1730 1740 1750
NLLPESLENM IYGKTGLSQE PHSFQEAPTT NTQSRKNTIT ISASRNESCQ
1760 1770 1780 1790 1800
PPGIEAEITS ASSLMSSLEA GVAKMNIKNG KHLLVSISKE GEPCCSETGR
1810 1820 1830 1840 1850
RPETIGHREA KCLVSPTLDT GHESGFVDLC SLSVYDPKRN FSSDQQLIDL
1860 1870 1880 1890 1900
LENKSLESKL ILNQSDEEEE ENEDETLAIV ASATEKPEVL DFPKPTVNIP
1910 1920 1930 1940 1950
RGKNLSFHQD EAKKGRLEVV SKTAGPQRVF PPPANQCHCK HIERWAHGLG
1960 1970 1980 1990 2000
SEDSEVEKPK AYQPDLYRSK ANNSTVEGET AVIPTEPFKL KHELLKEPWK
2010 2020 2030 2040 2050
ESSEGGKSFS MYAPEGSEPK PEDMDFENKD DYEKDGTCLS QDYPGKYSEE
2060 2070 2080 2090 2100
ESKSSASGIA GDLGEEAQEV RAPTIAQLLQ EKTLYSFSEW PKDRVIINRL
2110 2120 2130 2140 2150
DNICHVVLKG KWPCSHQYEP SGALPTPVLS SSAGSRSSLS EPEATEHGFS
2160 2170 2180 2190 2200
NGAALAAQIQ KESFLAPVFT KDEQKHRRPY EFEVERDAKA RSLEEYSATH
2210 2220 2230 2240 2250
GRPPIVLNGW HGESAIDLSC SSEGSPGATS PFPVSASTPK IGAISSLQGA
2260 2270 2280 2290 2300
LGMDLSGILQ AGLIHPVTGQ IVNGSLRRDD AAMRRRRGRR KHIEGGMDLI
2310 2320 2330 2340 2350
FLKEQTLQAG ILEVHEDAGQ TTLSTTHPEV PGATSSAPEP TAAASSQAEK
2360 2370 2380 2390 2400
AVPSKSLLDW LRQQADYSLD VPGFGTSFSD KPKQRRPRCK EPGKLDISSL
2410 2420 2430 2440 2450
GGEERVPAVP KEPGLRGFLP ESKFNHTLAE PVLRDAGPRR RGRRPRNELL
2460 2470 2480 2490 2500
KAPAIVADSP SGMGPLFMNG LIAGMDLVGL QNVRNIPGIP LTGLVGFPAG
2510 2520 2530 2540 2550
FATMPTGEEV KNTLSMLPMM LPGMAAVPQM FGVGGLLNTP MATTCTTTAS
2560 2570 2580 2590 2600
ASLASTKSGT SATEKSTEDK LSGHDVNTDA LVDDKPGPSP FSDQSEPTIT
2610 2620 2630 2640 2650
TSSPVAFNPF LIPGVSPGLI YPSMFLSPGM GMALPAMQQA RHSEMVGLET
2660 2670 2680 2690 2700
QKRKKKKTKG DSPTQEPASV CEKEPGSDQN CTESSATVSP EREHVAQARE
2710
EGLKDSNEDT N
Length:2,711
Mass (Da):305,397
Last modified:April 3, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i256A4983B8EA3544
GO
Isoform 2 (identifier: A3KFM7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-184: Missing.

Note: No experimental confirmation available.
Show »
Length:2,710
Mass (Da):305,310
Checksum:iADB0ED856383FDD9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A3KFM8A3KFM8_MOUSE
Chromodomain-helicase-DNA-binding p...
Chd6
1,183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A3KFM6A3KFM6_MOUSE
Chromodomain-helicase-DNA-binding p...
Chd6
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC65778 differs from that shown. Probable cloning artifact. Spurious priming from an intronic poly-A tract.Curated
The sequence BAC65778 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti756K → R in BAE24963 (PubMed:16141072).Curated1
Sequence conflicti1305L → H in BAE24963 (PubMed:16141072).Curated1
Sequence conflicti1741I → V in AAI50807 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054901184Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL590430 Genomic DNA No translation available.
AL591763 Genomic DNA No translation available.
BC150806 mRNA Translation: AAI50807.1
AK142177 mRNA Translation: BAE24963.1
AK122496 mRNA Translation: BAC65778.2 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS17000.1 [A3KFM7-1]

NCBI Reference Sequences

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RefSeqi
NP_775544.2, NM_173368.3 [A3KFM7-1]
XP_011238078.1, XM_011239776.2 [A3KFM7-2]
XP_017174747.1, XM_017319258.1 [A3KFM7-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.122738

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000039782; ENSMUSP00000042291; ENSMUSG00000057133 [A3KFM7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
71389

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:71389

UCSC genome browser

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UCSCi
uc008nrn.2 mouse [A3KFM7-1]
uc008nrp.2 mouse [A3KFM7-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590430 Genomic DNA No translation available.
AL591763 Genomic DNA No translation available.
BC150806 mRNA Translation: AAI50807.1
AK142177 mRNA Translation: BAE24963.1
AK122496 mRNA Translation: BAC65778.2 Sequence problems.
CCDSiCCDS17000.1 [A3KFM7-1]
RefSeqiNP_775544.2, NM_173368.3 [A3KFM7-1]
XP_011238078.1, XM_011239776.2 [A3KFM7-2]
XP_017174747.1, XM_017319258.1 [A3KFM7-1]
UniGeneiMm.122738

3D structure databases

ProteinModelPortaliA3KFM7
SMRiA3KFM7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA3KFM7, 1 interactor
STRINGi10090.ENSMUSP00000042291

PTM databases

iPTMnetiA3KFM7
PhosphoSitePlusiA3KFM7

Proteomic databases

MaxQBiA3KFM7
PaxDbiA3KFM7
PeptideAtlasiA3KFM7
PRIDEiA3KFM7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039782; ENSMUSP00000042291; ENSMUSG00000057133 [A3KFM7-1]
GeneIDi71389
KEGGimmu:71389
UCSCiuc008nrn.2 mouse [A3KFM7-1]
uc008nrp.2 mouse [A3KFM7-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84181
MGIiMGI:1918639 Chd6

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG0383 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00940000158986
HOGENOMiHOG000246942
HOVERGENiHBG107676
InParanoidiA3KFM7
KOiK14436
OMAiTIYQRCN
OrthoDBi7181at2759
PhylomeDBiA3KFM7
TreeFamiTF313572

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Chd6 mouse

Protein Ontology

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PROi
PR:A3KFM7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000057133 Expressed in 263 organ(s), highest expression level in substantia nigra
ExpressionAtlasiA3KFM7 baseline and differential
GenevisibleiA3KFM7 MM

Family and domain databases

CDDicd00024 CHROMO, 2 hits
cd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR006576 BRK_domain
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00385 Chromo, 2 hits
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00592 BRK, 1 hit
SM00298 CHROMO, 2 hits
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
SSF54160 SSF54160, 2 hits
PROSITEiView protein in PROSITE
PS50013 CHROMO_2, 1 hit
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHD6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A3KFM7
Secondary accession number(s): B9EKA7, Q3UQS6, Q80TE9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 11, 2014
Last sequence update: April 3, 2007
Last modified: January 16, 2019
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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