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UniProtKB - A3FQ79 (A3FQ79_CRYPI)
Protein
Mitogen-activated protein kinase
Gene
cgd2_1960
Organism
Cryptosporidium parvum (strain Iowa II)
Status
Functioni
Caution
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported
Catalytic activityi
- EC:2.7.11.24UniRule annotation
Cofactori
Mg2+UniRule annotation
Activity regulationi
Activated by threonine and tyrosine phosphorylation.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 43 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- MAP kinase activity Source: UniProtKB-EC
- protein serine/threonine/tyrosine kinase activity Source: RHEA
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotationARBA annotation, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, MagnesiumUniRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Mitogen-activated protein kinaseUniRule annotationARBA annotation (EC:2.7.11.24UniRule annotationARBA annotation) |
Gene namesi | ORF Names:cgd2_1960Imported |
Organismi | Cryptosporidium parvum (strain Iowa II)Imported |
Taxonomic identifieri | 353152 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Conoidasida › Coccidia › Eucoccidiorida › Eimeriorina › Cryptosporidiidae › Cryptosporidium › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | CryptoDB:cgd2_1960 |
Interactioni
Protein-protein interaction databases
STRINGi | 353152.A3FQ79 |
Chemistry databases
BindingDBi | A3FQ79 |
Structurei
3D structure databases
SMRi | A3FQ79 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | A3FQ79 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 334 | Protein kinaseInterPro annotationAdd BLAST | 322 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 433 – 456 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 433 – 450 | Polar residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.UniRule annotation
Phylogenomic databases
InParanoidi | A3FQ79 |
OMAi | TKPHIGS |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR003527, MAP_kinase_CS IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351, MAPK, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
A3FQ79-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCDRVDRHVL RKYELVKKLG KGAYGIVWKS IDRRTGEVVA VKKIFDAFQN
60 70 80 90 100
STDAQRTFRE IMILTELSGH ENIVNLLNVL RADNDRDVYL VFDYMETDLH
110 120 130 140 150
AVIRANILEP VHKQYVVYQL IKVIKYLHSG GLLHRDMKPS NILLNAECHV
160 170 180 190 200
KVADFGLSRS FVNIRRVTNN IPLSINENTE NFDDDQPILT DYVATRWYRA
210 220 230 240 250
PEILLGSTKY TKGIDMWSLG CILGEILCGK PIFPGSSTMN QLERIIGVID
260 270 280 290 300
FPSNEDVESI QSPFAKTMIE SLKEKVEIRQ SNKRDIFTKW KNLLLKINPK
310 320 330 340 350
ADCNEEALDL LDKLLQFNPN KRISANDALK HPFVSIFHNP NEEPNCDHII
360 370 380 390 400
TIPINDNVKH SIDDYRNLVY SEISRRKREL ISNKHQNVQN PNTAVSNPRV
410 420 430 440 450
NRVSGAVEFA TPECNPDNIT SNKSNEPIYS KFQSELQSNK RSSINKNPPA
460 470 480 490 500
DNSKKGGILG NFFSQVYNTF ISGSATNKTT SFGNSPAISN FSNGKVDEKH
510 520 530 540 550
IQQMRSAASY YSSSINNSNP IKKGGGFIGN NLSSTNDNTT KATNSSTKNS
560 570 580 590 600
KYISTGAVIK NANSTFSVST NCGGNSHVYY PRAYMYNNIK HNLPDYSLIP
610 620 630 640 650
NSESSNSLLG KNTSNLKYSN NPELSNQFKL NCHGSNQTSI INLQMQQNRS
660 670 680 690 700
NTSKITYYNE PNIEPNSKLN DMVGRKSTSS GVGVNTLHHP PPFYTSQQNK
710
NVNKNYLYKY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAEE01000005 Genomic DNA Translation: EAZ51388.1 |
RefSeqi | XP_001388215.1, XM_001388178.1 |
Genome annotation databases
EnsemblProtistsi | EAZ51388; EAZ51388; cgd2_1960 |
GeneIDi | 3373441 |
KEGGi | cpv:cgd2_1960 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAEE01000005 Genomic DNA Translation: EAZ51388.1 |
RefSeqi | XP_001388215.1, XM_001388178.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3OZ6 | X-ray | 2.37 | A/B | 4-390 | [»] | |
SMRi | A3FQ79 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 353152.A3FQ79 |
Chemistry databases
BindingDBi | A3FQ79 |
ChEMBLi | CHEMBL4295632 |
Genome annotation databases
EnsemblProtistsi | EAZ51388; EAZ51388; cgd2_1960 |
GeneIDi | 3373441 |
KEGGi | cpv:cgd2_1960 |
Organism-specific databases
VEuPathDBi | CryptoDB:cgd2_1960 |
Phylogenomic databases
InParanoidi | A3FQ79 |
OMAi | TKPHIGS |
Miscellaneous databases
EvolutionaryTracei | A3FQ79 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR003527, MAP_kinase_CS IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351, MAPK, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A3FQ79_CRYPI | |
Accessioni | A3FQ79Primary (citable) accession number: A3FQ79 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 3, 2007 |
Last sequence update: | April 3, 2007 | |
Last modified: | January 19, 2022 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |