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Entry version 80 (08 May 2019)
Sequence version 1 (20 Mar 2007)
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Protein
Submitted name:

Lactoperoxidase

Gene

LPO

Organism
Capra hircus (Goat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei225Heme (covalent)Combined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi227CalciumCombined sources1
Metal bindingi301CalciumCombined sources1
Metal bindingi303Calcium; via carbonyl oxygenCombined sources1
Metal bindingi305CalciumCombined sources1
Metal bindingi307CalciumCombined sources1
Metal bindingi339Zinc; via pros nitrogenCombined sources1
Binding sitei375Heme (covalent)Combined sources1
Metal bindingi468Iron (heme axial ligand); via tele nitrogenCombined sources1
Metal bindingi655ZincCombined sources1
Metal bindingi675Zinc; via pros nitrogenCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, PeroxidaseImported
LigandCalciumCombined sources, HemeCombined sources, Iron, Metal-binding, ZincCombined sources

Protein family/group databases

PeroxiBase, a peroxidase database

More...
PeroxiBasei
5320 ChiLPO01

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LactoperoxidaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LPOImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCapra hircus (Goat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9925 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500265289422 – 712Sequence analysisAdd BLAST691

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi123 ↔ 284Combined sources
Disulfide bondi132 ↔ 145Combined sources
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi212N-linked (GlcNAc...) asparagineCombined sources1
Disulfide bondi246 ↔ 256Combined sources
Disulfide bondi250 ↔ 274Combined sources
Glycosylationi322N-linked (GlcNAc...) asparagineCombined sources1
Disulfide bondi354 ↔ 365Combined sources
Glycosylationi358N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi449N-linked (GlcNAc...) asparagineCombined sources1
Disulfide bondi573 ↔ 630Combined sources
Disulfide bondi671 ↔ 696Combined sources

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A3F9D6

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
A3F9D6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K12550

Database of Orthologous Groups

More...
OrthoDBi
276568at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.640.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019791 Haem_peroxidase_animal
IPR010255 Haem_peroxidase_sf
IPR037120 Haem_peroxidase_sf_animal
IPR029587 LPO

The PANTHER Classification System

More...
PANTHERi
PTHR11475:SF67 PTHR11475:SF67, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03098 An_peroxidase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00457 ANPEROXIDASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48113 SSF48113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50292 PEROXIDASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A3F9D6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVCLHLQVF LASVALFEVA ASDTIAQAAS TTTISDAVSK VKTQVNKAFL
60 70 80 90 100
DSRTRLKTAL SSEAPTTRQL SEYFKHAKGR TRTAIRNGQV WEESLKRLRR
110 120 130 140 150
DTTLTNVTDP SLELTALSWE VGCGAPVPLV TCDEQSPYRT ITGDCNNRRS
160 170 180 190 200
PALGAANRAL ARWLPAEYED GLAVPFGWTQ RKTRNGFRVP LAREVSNKIV
210 220 230 240 250
GYLDEEGVLD QNRSLLFMQW GQIVDHDLDF APETELGSSE HSKVQCEEYC
260 270 280 290 300
VQGDECFPIM FPKNDPKLKT QGKCMPFFRA GFVCPTPPYQ SLARDQINAV
310 320 330 340 350
TSFLDASLVY GSEPSLASRL RNLSSPLGLM AVNQEAWDHG LAYPPFNNVK
360 370 380 390 400
PSPCEFINTT AHVPCFQAGD SRASEQILLA TVHTLLLREH NRLARELKRL
410 420 430 440 450
NPHWDGEMLY QEARKILGAF IQIITFRDYL PIVLGSEMQK WIPPYQGYNN
460 470 480 490 500
SVDPRISNVF TFAFRFGHME VPSTVSRLDE NYQPWGPEAE LPLHTLFFNT
510 520 530 540 550
WRIIKDGGID PLVRGLLAKN SKLMNQNKMV TSELRNKLFQ PTHKVHGFDL
560 570 580 590 600
AAINLQRCRD HGMPGYNSWR GFCGLSQPKT LKGLQAVLKN KVLAKKLLDL
610 620 630 640 650
YKTPDNIDIW IGGNAEPMVE RGRVGPLLAC LLGRQFQQIR DGDRFWWENP
660 670 680 690 700
GVFTEKQRDS LQKVSFSRLI CDNTHITKVP LHAFQANNYP HDFVDCSAVD
710
KLDLSPWASR EN
Length:712
Mass (Da):80,340
Last modified:March 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i061AE6125770A2FE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF363153 mRNA Translation: ABN41562.1

NCBI Reference Sequences

More...
RefSeqi
NP_001272546.1, NM_001285617.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100860761

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
chx:100860761

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF363153 mRNA Translation: ABN41562.1
RefSeqiNP_001272546.1, NM_001285617.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E9EX-ray3.25A/B118-712[»]
2EFBX-ray2.94A/B118-712[»]
2EHAX-ray3.30A/B118-712[»]
2OJVX-ray2.40A118-712[»]
2R5LX-ray2.40A118-712[»]
3N8FX-ray3.25A/B118-712[»]
3NAKX-ray3.30A/B118-712[»]
3NIUX-ray2.94A/B118-712[»]
3QF1X-ray2.60A118-712[»]
3R55X-ray2.10A118-712[»]
3RKEX-ray2.30A118-712[»]
3SXVX-ray2.10A118-712[»]
4IG5X-ray1.97A/B118-712[»]
4LJJX-ray1.98A118-712[»]
4MSFX-ray1.98A118-712[»]
4N7AX-ray1.79A118-712[»]
4OEKX-ray2.47A118-712[»]
4QJQX-ray2.10A118-712[»]
4QYQX-ray2.50A/B/C/D118-712[»]
5FF1X-ray1.97A/B118-712[»]
5HPWX-ray2.50A/B/C/D118-712[»]
SMRiA3F9D6
ModBaseiSearch...

Protein family/group databases

PeroxiBasei5320 ChiLPO01

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100860761
KEGGichx:100860761

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4025

Phylogenomic databases

KOiK12550
OrthoDBi276568at2759

Miscellaneous databases

EvolutionaryTraceiA3F9D6

Family and domain databases

Gene3Di1.10.640.10, 1 hit
InterProiView protein in InterPro
IPR019791 Haem_peroxidase_animal
IPR010255 Haem_peroxidase_sf
IPR037120 Haem_peroxidase_sf_animal
IPR029587 LPO
PANTHERiPTHR11475:SF67 PTHR11475:SF67, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS50292 PEROXIDASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA3F9D6_CAPHI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A3F9D6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 20, 2007
Last sequence update: March 20, 2007
Last modified: May 8, 2019
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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