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Protein

Genome polyprotein

Gene

NS3

Organism
Hepacivirus C
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseSAAS annotation, Hydrolase, Nucleotidyltransferase, RNA-directed RNA polymeraseSAAS annotation, Transferase
Biological processViral RNA replicationSAAS annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyproteinSAAS annotation
Gene namesi
Name:NS3Imported
OrganismiHepacivirus CImported
Taxonomic identifieri11103 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageFlaviviridaeHepacivirus

Subcellular locationi

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell

Keywords - Cellular componenti

VirionSAAS annotation

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4893
DrugBankiDB11586 Asunaprevir

Structurei

3D structure databases

SMRiA3EZI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 182Peptidase S29InterPro annotationAdd BLAST182
Domaini191 – 343Helicase ATP-bindingInterPro annotationAdd BLAST153
Domaini335 – 512Helicase C-terminalInterPro annotationAdd BLAST178

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011492 DEAD_Flavivir
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR009003 Peptidase_S1_PA
IPR004109 Peptidase_S29_NS3
PfamiView protein in Pfam
PF07652 Flavi_DEAD, 1 hit
PF02907 Peptidase_S29, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51822 HV_PV_NS3_PRO, 1 hit

Sequencei

Sequence statusi: Fragment.

A3EZI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
APITAYAQQT RGLLGCIITS LTGRDKNQVE GEVQIVSTAA QTFLATCING
60 70 80 90 100
VCWTVYHGAG TRTIASSKGP VIQMYTNVDQ DLVGWPAPQG ARSLTPCTCG
110 120 130 140 150
SSDLYLVTRH ADVIPVRRRG DGRGSLLSPR PISYLKGSSG GPLLCPAGHA
160 170 180 190 200
VGIFRAAVCT RGVAKAVDFI PVEGLETTMR SPVFSDNSSP PAVPQSYQVA
210 220 230 240 250
HLHAPTGSGK STKVPAAYAA QGYKVLVLNP SVAATLGFGA YMSKAHGIDP
260 270 280 290 300
NIRTGVRTIT TGSPITYSTY GKFLADGGCS GGAYDIIICD ECHSTDATSI
310 320 330 340 350
LGIGTVLDQA ETAGARLTVL ATATPPGSVT VPHPNIEEVA LSTTGEIPFY
360 370 380 390 400
GKAIPLEAIK GGRHLIFCHS KKKCDELAAK LVALGVNAVA YYRGLDVSVI
410 420 430 440 450
PASGDVVVVA TDALMTGFTG DFDSVIDCNT CVTQTVDFSL DPTFTIETTT
460 470 480 490 500
LPQDAVSRTQ RRGRTGRGKP GIYRFVTPGE RPSGMFDSSV LCECYDAGCA
510 520 530 540 550
WYELTPAETT VRLRAYMNTP GLPVCQDHLE FWEGVFTGLT HIDAHFLSQT
560 570 580 590 600
KQSGENLPYL VAYQATVCAR AQAPPPSWDQ MWKCLIRLKP TLHGPTPLLY
610 620 630
RLGAVQNEIT LTHPITKYIM TCMSADLEVV T
Length:631
Mass (Da):67,062
Last modified:March 20, 2007 - v1
Checksum:iB6A0867B8318D75D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei631Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF173649 Genomic RNA Translation: ABN45872.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF173649 Genomic RNA Translation: ABN45872.1

3D structure databases

SMRiA3EZI9
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL4893
DrugBankiDB11586 Asunaprevir

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

euHCVdbiEF173649

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011492 DEAD_Flavivir
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR009003 Peptidase_S1_PA
IPR004109 Peptidase_S29_NS3
PfamiView protein in Pfam
PF07652 Flavi_DEAD, 1 hit
PF02907 Peptidase_S29, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51822 HV_PV_NS3_PRO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA3EZI9_9HEPC
AccessioniPrimary (citable) accession number: A3EZI9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 20, 2007
Last sequence update: March 20, 2007
Last modified: February 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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