UniProtKB - A3EXG8 (VEMP_BCHK9)
Protein
Envelope small membrane protein
Gene
E
Organism
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9)
Status
Functioni
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.UniRule annotation
GO - Biological processi
- disruption by virus of host cell membrane Source: UniProtKB-UniRule
- pore formation by virus in membrane of host cell Source: InterPro
- viral budding from Golgi membrane Source: UniProtKB-UniRule
Keywordsi
Biological process | Apoptosis |
Names & Taxonomyi
Protein namesi | Recommended name: Envelope small membrane proteinUniRule annotationShort name: E proteinUniRule annotation Short name: sM proteinUniRule annotation |
Gene namesi | Name:EUniRule annotation Synonyms:sM ORF Names:4 |
Organismi | Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) |
Taxonomic identifieri | 694006 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Nobecovirus |
Virus hosti | Rousettus leschenaultii (Leschenault's rousette) [TaxID: 9408] |
Proteomesi |
|
Subcellular locationi
- Host Golgi apparatus membrane UniRule annotation; Single-pass type III membrane protein UniRule annotation Note: The cytoplasmic tail functions as a Golgi complex-targeting signal.UniRule annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 16 | Virion surfaceUniRule annotationAdd BLAST | 16 | |
Transmembranei | 17 – 37 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 38 – 75 | IntravirionUniRule annotationAdd BLAST | 38 |
GO - Cellular componenti
- host cell Golgi membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-UniRule
Keywords - Cellular componenti
Host Golgi apparatus, Host membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000291371 | 1 – 79 | Envelope small membrane proteinAdd BLAST | 79 |
Interactioni
Subunit structurei
Homopentamer.
Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex.
Interacts with Nucleoprotein.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Belongs to the betacoronaviruses E protein family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
HAMAPi | MF_04204, BETA_CORONA_E, 1 hit |
InterProi | View protein in InterPro IPR043506, E_protein_bCoV IPR003873, E_protein_CoV |
Pfami | View protein in Pfam PF02723, CoV_E, 1 hit |
PROSITEi | View protein in PROSITE PS51926, COV_E, 1 hit |
i Sequence
Sequence statusi: Complete.
A3EXG8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYDIVGTNNS ILIANVLVLI IICLLVVIVG CALLLILQFV FGVCGFVFKF
60 70
VCKPTILVYN KFRNESLLNE REELLCDNV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF065513 Genomic RNA Translation: ABN10913.1 |
RefSeqi | YP_001039973.1, NC_009021.1 |
Genome annotation databases
GeneIDi | 4836015 |
KEGGi | vg:4836015 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF065513 Genomic RNA Translation: ABN10913.1 |
RefSeqi | YP_001039973.1, NC_009021.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 4836015 |
KEGGi | vg:4836015 |
Family and domain databases
HAMAPi | MF_04204, BETA_CORONA_E, 1 hit |
InterProi | View protein in InterPro IPR043506, E_protein_bCoV IPR003873, E_protein_CoV |
Pfami | View protein in Pfam PF02723, CoV_E, 1 hit |
PROSITEi | View protein in PROSITE PS51926, COV_E, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VEMP_BCHK9 | |
Accessioni | A3EXG8Primary (citable) accession number: A3EXG8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 12, 2007 |
Last sequence update: | March 20, 2007 | |
Last modified: | October 7, 2020 | |
This is version 55 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families