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UniProtKB - A3EX97 (ORF4B_BCHK4)
Protein
Non-structural protein ORF4b
Gene
ORF4b
Organism
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004)
Status
Functioni
Plays a role in the inhibition of host innate immunity by inhibiting the interaction between host IKBKE and MAVS. In turn, this inhibition prevents the production of host interferon beta. Additionally, may also interfere with host antiviral response within the nucleus.
1 PublicationGO - Biological processi
- suppression by virus of host type I interferon production Source: UniProtKB
- suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction, Inhibition of host IKBKE by virus, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion |
Names & Taxonomyi
Protein namesi | Recommended name: Non-structural protein ORF4bShort name: ORF4b |
Gene namesi | Name:ORF4b |
Organismi | Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) |
Taxonomic identifieri | 694007 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Merbecovirus |
Virus hosti | Tylonycteris pachypus (Lesser bamboo bat) (Vespertilio pachypus) [TaxID: 258959] |
Proteomesi |
|
Subcellular locationi
- Host nucleus 1 Publication
- host nucleolus By similarity
- Host cytoplasm By similarity Note: Mainly localized in the host nucleus.By similarity
Keywords - Cellular componenti
Host cytoplasm, Host nucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000290268 | 1 – 285 | Non-structural protein ORF4bAdd BLAST | 285 |
Structurei
Family & Domainsi
Family and domain databases
CDDi | cd21652, ORF4b_HKU4-CoV, 1 hit |
InterProi | View protein in InterPro IPR044319, ORF4b_HKU4-CoV |
i Sequence
Sequence statusi: Complete.
A3EX97-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSIVLRLLSV LKHQQNKMQL DLSVNSYKLL DYSMEWSSDS VVLPPTSSDK
60 70 80 90 100
TVMMPAKATS SRKRHRKPKL QYAKRRFSPV NPNDLVLVQQ EPTHCVRLVF
110 120 130 140 150
PLSKRWIHFD GLVYSLARLN VSMTVDYHVT LALIYAPEAG ECFGNFLHLC
160 170 180 190 200
PLLKDCLLEF KKLCVLGKTL TILASEWPFF TDVKKNKDNL TVPKAVEWLK
210 220 230 240 250
EHGYEIYNSQ LPLHMSLAKL HDLPQAQFAE AAGLCHYFDP REFALPCALE
260 270 280
VVKIGGGKVN GRSIPLARFP INNEFKFIPY LYQCV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF065505 Genomic RNA Translation: ABN10842.1 |
RefSeqi | YP_001039956.1, NC_009019.1 |
Genome annotation databases
GeneIDi | 4835994 |
KEGGi | vg:4835994 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF065505 Genomic RNA Translation: ABN10842.1 |
RefSeqi | YP_001039956.1, NC_009019.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 4835994 |
KEGGi | vg:4835994 |
Family and domain databases
CDDi | cd21652, ORF4b_HKU4-CoV, 1 hit |
InterProi | View protein in InterPro IPR044319, ORF4b_HKU4-CoV |
MobiDBi | Search... |
Entry informationi
Entry namei | ORF4B_BCHK4 | |
Accessioni | A3EX97Primary (citable) accession number: A3EX97 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 12, 2007 |
Last sequence update: | March 20, 2007 | |
Last modified: | February 23, 2022 | |
This is version 50 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |