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Entry version 86 (31 Jul 2019)
Sequence version 1 (20 Mar 2007)
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Protein

DNA repair protein REV1

Gene

REV1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Deoxycytidyl transferase involved in DNA repair and translesion synthesis (TLS). Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. Mediates also the insertion of dTMP or dGMP when the opposite base is G, and, with a low efficiency, dGMP insertions opposite G, T, and C, dAMP insertions opposite G, A, and T, and dTMP insertion opposite A. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (e.g. UV and gamma ray), mostly via G to T transversions, and of spontaneous mutations in somatic cells. Confers resistance to ultraviolet-B (UV-B) and various DNA cross-linkers (e.g. mitomycin C MMC and cisplatin). Promotes stem growth.4 Publications

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+1 Publication, Mg2+1 PublicationNote: Mn2+ ions. Can also use Mg2+ ions with a lower efficiency.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei335dCTPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi379Manganese 1By similarity1
Metal bindingi379Manganese 2By similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei384Substrate discriminationPROSITE-ProRule annotation1
Metal bindingi476Manganese 1By similarity1
Binding sitei476dCTPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei477PROSITE-ProRule annotation1
Metal bindingi477Manganese 1By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi379 – 383dCTP bindingBy similarity5
Nucleotide bindingi416 – 422dCTP bindingBy similarity7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA synthesis
LigandMagnesium, Manganese, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA repair protein REV1 (EC:2.7.7.-)
Short name:
AtREV1
Alternative name(s):
Rev1-like terminal deoxycytidyl transferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:REV1
Ordered Locus Names:At5g44750
ORF Names:K23L20.9, T19K24.14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G44750

The Arabidopsis Information Resource

More...
TAIRi
locus:2156319 AT5G44750

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Reduced UV light- and gamma ray-induced mutation frequency. Slightly sensitive to ultraviolet-B (UV-B) and DNA cross-linkers (e.g. mitomycin C MMC and cisplatin). Lower germination rate.4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004165951 – 1105DNA repair protein REV1Add BLAST1105

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A3EWL3

PRoteomics IDEntifications database

More...
PRIDEi
A3EWL3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A3EWL3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A3EWL3 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei676Interaction with target DNABy similarity1

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT5G44750.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A3EWL3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini83 – 174BRCTPROSITE-ProRule annotationAdd BLAST92
Domaini375 – 556UmuCPROSITE-ProRule annotationAdd BLAST182

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni330 – 340Interaction with target DNABy similarityAdd BLAST11
Regioni556 – 559Interaction with target DNABy similarity4
Regioni612 – 620Interaction with target DNABy similarity9
Regioni1021 – 1103Protein interaction domain; mediates interaction with DNA polymerase zetaBy similarityAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi953 – 961Nuclear localization signalSequence analysis9

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal domain is necessary for protein interactions.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-Y family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2093 Eukaryota
COG0389 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000246421

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A3EWL3

KEGG Orthology (KO)

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KOi
K03515

Identification of Orthologs from Complete Genome Data

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OMAi
LFAQRFE

Database of Orthologous Groups

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OrthoDBi
299766at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A3EWL3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.100, 1 hit
3.40.50.10190, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR036775 DNA_pol_Y-fam_lit_finger_sf
IPR017961 DNA_pol_Y-fam_little_finger
IPR012112 REV1
IPR001126 UmuC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16589 BRCT_2, 1 hit
PF00817 IMS, 1 hit
PF11799 IMS_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036573 REV1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00292 BRCT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100879 SSF100879, 1 hit
SSF52113 SSF52113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172 BRCT, 1 hit
PS50173 UMUC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A3EWL3-1) [UniParc]FASTAAdd to basket
Also known as: AtREV1-1105

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRSLGSNSS NNSGSGSNKK SKKNNNPSNQ KTLGAAWGAA SSRSSFRSSP
60 70 80 90 100
FSDFGSYMEV KNRKLQNQFE TEASAASRGV SGSEKLIFQG VSIFVDGFTI
110 120 130 140 150
PSHQELKGYM MKYGGRFENY FSRRSVTHII CSNLPDSKVK NLRTFSRGLP
160 170 180 190 200
VVKPTWIVDS ISANRLLGWV PYQLDQLNDT QPKLSAFFAP RSHLTPQMAS
210 220 230 240 250
PVTSFQPDTG YSEAEEGSSI RADDSEEARD HIDDEIDGVY IENTTPELTE
260 270 280 290 300
QTGTGDLKSS EMNAEGLGNY DIEEKEVSSE LQSTTNLHST SDNKSVHANG
310 320 330 340 350
KNGGKSIATA AGSSTRRHST LEDPNFVENY FKNSRLHFIG TWRNRYRKRF
360 370 380 390 400
HGSSNGLKWA DSGQNTAEMA KKSTIIHIDL DCFFVSVVIK NRLELHDKPV
410 420 430 440 450
AVCHSDNPKG TAEISSANYP ARAYGVKAGM FVRHAKDLCP QLVIVPYNFE
460 470 480 490 500
AYEEVADQFY DILHRHCRKV QALSCDEAFL DVSDLSDVET EVLASTIRNE
510 520 530 540 550
ILETTGCSAS AGIGGTMLMA RLATRVAKPA GQLYISAEKV EEFLDQLPVG
560 570 580 590 600
TLPGVGSVLK EKLVKQNIQT CGQLRLISKD SLQKDFGVKT GEMLWSYSRG
610 620 630 640 650
LDLRSVTAVQ ESKSIGAEVN WGVRFRDQQD VFILVQHFLQ CLCKEVSLRL
660 670 680 690 700
QGCEMIGRTF TLKIKKRKKD AEEPTKYMGC GDCDNLSRSI TVPAATDDIE
710 720 730 740 750
VLQRISKKLF GSFCLDVKEV RGVGLQVSKL DSADPSNKGS RTLKSWLSSA
760 770 780 790 800
PAVVQIEQDD NVFAAKVREN SDCNRPVTGG VSRLRESNSE ESSIQSGDTN
810 820 830 840 850
SSLPPMCYLD MEVLENLPPE LLSELDGTYG GKLFELIEKK RGKRRINCNS
860 870 880 890 900
PHVSLDGTAA SIKELKSLSV KIHGLSTSGE KEYKEPYVPH PSIARTSNQH
910 920 930 940 950
TIEMTDLLPS SLSQVDVSVL QELPEELRAD VLGAFPSHRR QQSSSDVPKE
960 970 980 990 1000
TCKKQDEEPI DLKGTENEIG LSFSSLWFGN PPLWTEKFKV SGNCTMEKLS
1010 1020 1030 1040 1050
AIYFKVAQSR PMLSLVLQHA ISEMSSFPDA ASASDLDKAI YDVCELLKQY
1060 1070 1080 1090 1100
INLKVGGDIE EIYLCFRLLK RLAARSQLFL QVYEILSPFI QASISEHYGG

SLSIP
Length:1,105
Mass (Da):122,233
Last modified:March 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i77C0814E4CAD79DE
GO
Isoform 2 (identifier: A3EWL3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     631-634: Missing.

Note: No experimental confirmation available.
Show »
Length:1,101
Mass (Da):121,760
Checksum:i3ACF6B5234E4C7C3
GO
Isoform 3 (identifier: A3EWL3-3) [UniParc]FASTAAdd to basket
Also known as: AtREV1-431

The sequence of this isoform differs from the canonical sequence as follows:
     426-1105: VKAGMFVRHA...EHYGGSLSIP → LSYTKE

Note: No experimental confirmation available.
Show »
Length:431
Mass (Da):47,595
Checksum:i4B08FADBCE4928A6
GO
Isoform 4 (identifier: A3EWL3-4) [UniParc]FASTAAdd to basket
Also known as: AtREV1-630

The sequence of this isoform differs from the canonical sequence as follows:
     613-1105: KSIGAEVNWG...EHYGGSLSIP → STLPPMPMQRSFFASARM

Note: No experimental confirmation available.
Show »
Length:630
Mass (Da):69,463
Checksum:iCE19E47439277C3E
GO
Isoform 5 (identifier: A3EWL3-5) [UniParc]FASTAAdd to basket
Also known as: AtREV1-651

The sequence of this isoform differs from the canonical sequence as follows:
     636-1105: QHFLQCLCKE...EHYGGSLSIP → NNVLLFFPKHYSFDVS

Note: No experimental confirmation available.
Show »
Length:651
Mass (Da):71,994
Checksum:iA5F9CC4732204CD0
GO
Isoform 6 (identifier: A3EWL3-6) [UniParc]FASTAAdd to basket
Also known as: AtREV1-436

The sequence of this isoform differs from the canonical sequence as follows:
     430-1105: MFVRHAKDLC...EHYGGSLSIP → IAEKSRR

Note: No experimental confirmation available.
Show »
Length:436
Mass (Da):48,069
Checksum:i659E314A509DCB83
GO
Isoform 7 (identifier: A3EWL3-7) [UniParc]FASTAAdd to basket
Also known as: AtREV1-444

The sequence of this isoform differs from the canonical sequence as follows:
     333-539: Missing.
     636-1105: QHFLQCLCKE...EHYGGSLSIP → NNVLLFFPKHYSFDVS

Note: No experimental confirmation available.
Show »
Length:444
Mass (Da):49,003
Checksum:i3816C82F0AB63337
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC79145 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB08828 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042703333 – 539Missing in isoform 7. 1 PublicationAdd BLAST207
Alternative sequenceiVSP_042704426 – 1105VKAGM…SLSIP → LSYTKE in isoform 3. 1 PublicationAdd BLAST680
Alternative sequenceiVSP_042705430 – 1105MFVRH…SLSIP → IAEKSRR in isoform 6. 1 PublicationAdd BLAST676
Alternative sequenceiVSP_042706613 – 1105KSIGA…SLSIP → STLPPMPMQRSFFASARM in isoform 4. 1 PublicationAdd BLAST493
Alternative sequenceiVSP_042707631 – 634Missing in isoform 2. 1 Publication4
Alternative sequenceiVSP_042708636 – 1105QHFLQ…SLSIP → NNVLLFFPKHYSFDVS in isoform 5 and isoform 7. 1 PublicationAdd BLAST470

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB187523 mRNA Translation: BAD89586.1
EF016093 mRNA Translation: ABN48548.1
EF016094 mRNA Translation: ABN48549.1
EF016095 mRNA Translation: ABN48550.1
EF016096 mRNA Translation: ABN48551.1
EF016097 mRNA Translation: ABN48552.1
EF016098 mRNA Translation: ABN48553.1
AB016874 Genomic DNA Translation: BAB08828.1 Sequence problems.
AC002342 Genomic DNA Translation: AAC79145.1 Sequence problems.
CP002688 Genomic DNA Translation: AED95156.1
CP002688 Genomic DNA Translation: AED95157.1
AY080825 mRNA Translation: AAL87302.1

NCBI Reference Sequences

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RefSeqi
NP_001119373.1, NM_001125901.2 [A3EWL3-1]
NP_199288.4, NM_123842.5 [A3EWL3-2]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G44750.1; AT5G44750.1; AT5G44750 [A3EWL3-2]
AT5G44750.2; AT5G44750.2; AT5G44750 [A3EWL3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
834504

Gramene; a comparative resource for plants

More...
Gramenei
AT5G44750.1; AT5G44750.1; AT5G44750 [A3EWL3-2]
AT5G44750.2; AT5G44750.2; AT5G44750 [A3EWL3-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT5G44750

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB187523 mRNA Translation: BAD89586.1
EF016093 mRNA Translation: ABN48548.1
EF016094 mRNA Translation: ABN48549.1
EF016095 mRNA Translation: ABN48550.1
EF016096 mRNA Translation: ABN48551.1
EF016097 mRNA Translation: ABN48552.1
EF016098 mRNA Translation: ABN48553.1
AB016874 Genomic DNA Translation: BAB08828.1 Sequence problems.
AC002342 Genomic DNA Translation: AAC79145.1 Sequence problems.
CP002688 Genomic DNA Translation: AED95156.1
CP002688 Genomic DNA Translation: AED95157.1
AY080825 mRNA Translation: AAL87302.1
RefSeqiNP_001119373.1, NM_001125901.2 [A3EWL3-1]
NP_199288.4, NM_123842.5 [A3EWL3-2]

3D structure databases

SMRiA3EWL3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G44750.2

Proteomic databases

PaxDbiA3EWL3
PRIDEiA3EWL3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G44750.1; AT5G44750.1; AT5G44750 [A3EWL3-2]
AT5G44750.2; AT5G44750.2; AT5G44750 [A3EWL3-1]
GeneIDi834504
GrameneiAT5G44750.1; AT5G44750.1; AT5G44750 [A3EWL3-2]
AT5G44750.2; AT5G44750.2; AT5G44750 [A3EWL3-1]
KEGGiath:AT5G44750

Organism-specific databases

AraportiAT5G44750
TAIRilocus:2156319 AT5G44750

Phylogenomic databases

eggNOGiKOG2093 Eukaryota
COG0389 LUCA
HOGENOMiHOG000246421
InParanoidiA3EWL3
KOiK03515
OMAiLFAQRFE
OrthoDBi299766at2759
PhylomeDBiA3EWL3

Miscellaneous databases

Protein Ontology

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PROi
PR:A3EWL3

Gene expression databases

ExpressionAtlasiA3EWL3 baseline and differential
GenevisibleiA3EWL3 AT

Family and domain databases

Gene3Di3.30.1490.100, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR036775 DNA_pol_Y-fam_lit_finger_sf
IPR017961 DNA_pol_Y-fam_little_finger
IPR012112 REV1
IPR001126 UmuC
PfamiView protein in Pfam
PF16589 BRCT_2, 1 hit
PF00817 IMS, 1 hit
PF11799 IMS_C, 1 hit
PIRSFiPIRSF036573 REV1, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 1 hit
SUPFAMiSSF100879 SSF100879, 1 hit
SSF52113 SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS50173 UMUC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiREV1_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A3EWL3
Secondary accession number(s): A3EWL4
, A3EWL5, A3EWL6, A3EWL7, A3EWL8, O48585, Q5FBB9, Q8RXL1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: March 20, 2007
Last modified: July 31, 2019
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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