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Protein

Kappa-conotoxin Ac4.2

Gene
N/A
Organism
Conus achatinus (Little frog cone)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Kappa-conotoxins bind and inhibit voltage-gated potassium channels.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-conotoxin Ac4.2
OrganismiConus achatinus (Little frog cone)
Taxonomic identifieri369967 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPionoconus

Organism-specific databases

ConoServeri563 Ac4.2 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000370642‹1 – 11By similarityAdd BLAST›11
PeptideiPRO_000037064312 – 40Kappa-conotoxin Ac4.2Add BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei134-hydroxyprolineBy similarity1
Glycosylationi18O-linked (HexNAc...) threonineBy similarity1
Glycosylationi20O-linked (HexNAc...) threonineBy similarity1
Modified residuei334-hydroxyprolineBy similarity1
Modified residuei40Cysteine amideBy similarity1

Post-translational modificationi

Contains 3 disulfide bonds (By similarity). They are not added, since framework IV presents two different connectivities (I-V, II-III, IV-VI and I-III, II-V, IV-VI).By similarity

Keywords - PTMi

Amidation, Disulfide bond, Glycoprotein, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliA3DT44
SMRiA3DT44
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is IV (CC-C-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

A3DT44-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
FDGRNAAVNE RAPWMVVTAT TNCCGYTGPA CHPCLCTQSC G
Length:41
Mass (Da):4,307
Last modified:March 20, 2007 - v1
Checksum:i2F2E6FD405551713
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ311073 Genomic DNA Translation: ABD33865.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ311073 Genomic DNA Translation: ABD33865.1

3D structure databases

ProteinModelPortaliA3DT44
SMRiA3DT44
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri563 Ac4.2 precursor

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCA42_CONAH
AccessioniPrimary (citable) accession number: A3DT44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: March 20, 2007
Last modified: September 12, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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