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Entry version 81 (02 Jun 2021)
Sequence version 1 (20 Mar 2007)
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Protein
Submitted name:

S-layer domain-containing protein

Gene

Cthe_2506

Organism
Hungateiclostridium thermocellum (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Clostridium thermocellum)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
CTHE203119:G1G86-2627-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM3, Carbohydrate-Binding Module Family 3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
S-layer domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:Cthe_2506Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHungateiclostridium thermocellum (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Clostridium thermocellum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri203119 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaEubacterialesOscillospiraceaeAcetivibrio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002145 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei15 – 38HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
203119.Cthe_2506

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A3DIC9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini49 – 215CBM3InterPro annotationAdd BLAST167
Domaini831 – 894SLHInterPro annotationAdd BLAST64
Domaini895 – 954SLHInterPro annotationAdd BLAST60
Domaini958 – 1013SLHInterPro annotationAdd BLAST56

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni566 – 673DisorderedSequence analysisAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi569 – 673Pro residuesSequence analysisAdd BLAST105

Keywords - Domaini

RepeatARBA annotation, SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1657, Bacteria
COG2911, Bacteria
COG3266, Bacteria
COG3533, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_297309_0_0_9

Identification of Orthologs from Complete Genome Data

More...
OMAi
NDVHELD

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit
2.60.40.710, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025883, Cadherin-like_b_sandwich
IPR008965, CBM2/CBM3_carb-bd_dom_sf
IPR001956, CBM3
IPR036966, CBM3_sf
IPR013320, ConA-like_dom_sf
IPR008979, Galactose-bd-like_sf
IPR006558, LamG-like
IPR001119, SLH_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12733, Cadherin-like, 1 hit
PF00942, CBM_3, 1 hit
PF00395, SLH, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01067, CBM_3, 1 hit
SM00560, LamGL, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49384, SSF49384, 1 hit
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51172, CBM3, 1 hit
PS51272, SLH, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A3DIC9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKEKIGKVLR QNKSIISVVV ITAILFVYNT GMLFTGIWEG ALYNVKAEEV
60 70 80 90 100
PLKLEFFNNV KDDNVTLISP YFRVINNSSS DEIYLQHVKI RYYFTLDSSD
110 120 130 140 150
SEETMNYEIY YAGKSNIDGT GAVEDIKPNT IVKIAKMDIP TDMADHYLEI
160 170 180 190 200
GFDESCGTIG PDKKVEVMVS ISKEKYKKFI QTNDYSYNDS AENYVSWEKV
210 220 230 240 250
TLYLDGELIS GIEPNMYASR ETGAWYMFDE AVEGSTNEFK DYKGNHGNAV
260 270 280 290 300
LYSANGVVPG LNGNSVSLDG VDDYVALPDG IAGTFYNFTI AFWVRLDTIG
310 320 330 340 350
EQPIFDFFDS GSNNKYMRLT AESDGKIKFA MTQSGYYGEK TITSGSALTE
360 370 380 390 400
GVWKHVAVTL SGDTGTLYIN GENVGENNTL SLRPLTFLGE TSKGYIGKSH
410 420 430 440 450
QTDSSEDPYY NSYLHGMIDD FRIFDRALSA DEIKTLASVA TRVNDSDPGI
460 470 480 490 500
HYSSGWSHSQ ERDKGDYLND VHELDSPDGE NCFEYTFTGT GVNVIAPQCS
510 520 530 540 550
DNGDAEIYID GKLMKSVAMS VYSGYNSQAV VYSKLGLSLG THTIKVVFKN
560 570 580 590 600
GIGIIDALDI MTGEIVSPSP TPTPSPTPSP TPTPSPTPSP TPTPTPTPSS
610 620 630 640 650
TPTSTPTPEP SPTSTPTPEP SPTSTPTPEP EPEPTSTPTP ELSPSSTPVP
660 670 680 690 700
TPTPTPTPAP NPAPEPVPIS TPVPEPILIP TPTPTMTPMP TPTPTLEVKS
710 720 730 740 750
DPYLSDLVVT GAKLKPAFVP DILNYEAVAE EDVRFVCIVA YARDDGAEIT
760 770 780 790 800
LNGVPVKSGS ISHAVELKEG KNELIVKVVA EDGITSRTYR ISVLLEALQL
810 820 830 840 850
PTPTPDKSGN PFFSSLEDLL KENEVSPDGT KGGIFDDVPR GYWAEEYIQK
860 870 880 890 900
LYEKGIISGI DEKTFMPGRP ITRAEFTQII VNSLKIPYRE AGLHFNDVTE
910 920 930 940 950
KDWYYKSVSS AAAFGIVVGR PDGSFAPNEF ITRQDMAVVI AKFLEKKHDG
960 970 980 990 1000
NLEGMGKGLV FADSGNISEY ARDSVAAVVS QGLMVGKPGN MFDPKGLTTR
1010
AEAVTVICKL MKY
Length:1,013
Mass (Da):110,379
Last modified:March 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8564AF423C622D8D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP000568 Genomic DNA Translation: ABN53708.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ABN53708; ABN53708; Cthe_2506

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cth:Cthe_2506

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000568 Genomic DNA Translation: ABN53708.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4QVSX-ray2.10A221-444[»]
SMRiA3DIC9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi203119.Cthe_2506

Protein family/group databases

CAZyiCBM3, Carbohydrate-Binding Module Family 3

Genome annotation databases

EnsemblBacteriaiABN53708; ABN53708; Cthe_2506
KEGGicth:Cthe_2506

Phylogenomic databases

eggNOGiCOG1657, Bacteria
COG2911, Bacteria
COG3266, Bacteria
COG3533, Bacteria
HOGENOMiCLU_297309_0_0_9
OMAiNDVHELD

Enzyme and pathway databases

BioCyciCTHE203119:G1G86-2627-MONOMER

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.710, 1 hit
InterProiView protein in InterPro
IPR025883, Cadherin-like_b_sandwich
IPR008965, CBM2/CBM3_carb-bd_dom_sf
IPR001956, CBM3
IPR036966, CBM3_sf
IPR013320, ConA-like_dom_sf
IPR008979, Galactose-bd-like_sf
IPR006558, LamG-like
IPR001119, SLH_dom
PfamiView protein in Pfam
PF12733, Cadherin-like, 1 hit
PF00942, CBM_3, 1 hit
PF00395, SLH, 3 hits
SMARTiView protein in SMART
SM01067, CBM_3, 1 hit
SM00560, LamGL, 1 hit
SUPFAMiSSF49384, SSF49384, 1 hit
SSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51172, CBM3, 1 hit
PS51272, SLH, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA3DIC9_HUNT2
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A3DIC9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 20, 2007
Last sequence update: March 20, 2007
Last modified: June 2, 2021
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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