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Protein

DNA ligase

Gene

lig

Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei244ATPUniRule annotation1
Active sitei246N6-AMP-lysine intermediateUniRule annotation1
Binding sitei251ATPUniRule annotation1
Binding sitei266ATPUniRule annotation1
Binding sitei295ATPUniRule annotation1
Binding sitei334ATPUniRule annotation1
Binding sitei405ATPUniRule annotation1
Binding sitei411ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR368407:G1G85-1871-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Memar_1865
OrganismiMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Taxonomic identifieri368407 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
Proteomesi
  • UP000002146 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003652551 – 548DNA ligaseAdd BLAST548

Interactioni

Protein-protein interaction databases

STRINGi368407.Memar_1865

Structurei

3D structure databases

ProteinModelPortaliA3CWP1
SMRiA3CWP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

A3CWP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFLEFAQVC EHLEGTPGRL DMIEQVAAVL PRLDDEELPV FVRFVMGRVF
60 70 80 90 100
PDWSTKKLGV GPNLLYDAVA YVVGTKRETV REAINTTGDV GLAVEGLLAR
110 120 130 140 150
KEQTSFFIQE LDLLDVYREL ERMAAAEGQR SQREKLRVAQ GLFGNARPLE
160 170 180 190 200
GRYLARLLLE ELRIGMGEGN VRDAVAKAFE LDVRLVEHAH QALNDLGEVA
210 220 230 240 250
LLARRDPDAL SGVTIEPFRP VKMMLAQAGT IAAQIEDHGE VAVEYKYDGS
260 270 280 290 300
RFQFHKVGDV CRIYSRRLED VTESLPDIAN LLLEATDHDV ILDGEAVAVR
310 320 330 340 350
DGKPMPFQYV IRRFRRKHEV DSMMEKIELV PMVFDILYLD GETLMDRPLA
360 370 380 390 400
ERRKALDEVL GAHVAPQFPA TDAAAAEAIY AEALDLGHEG VMVKVLDSPY
410 420 430 440 450
TPGVRGRLWV KVKPGVETLD LVVVGAEWGE GRRAGTFGSF LLAVQDQGRL
460 470 480 490 500
LPVGKVATGI TDEVLAELYA LFKDRVIARS GKEVTLEPEV VFEVGYSEIQ
510 520 530 540
TSPNYESGYA LRFPRFVRVR EDKSVDETET LDSLAERYGR QRNGQGSL
Length:548
Mass (Da):61,157
Last modified:March 20, 2007 - v1
Checksum:i3544373E6F328D03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000562 Genomic DNA Translation: ABN57791.1
RefSeqiWP_011844700.1, NC_009051.1

Genome annotation databases

EnsemblBacteriaiABN57791; ABN57791; Memar_1865
GeneIDi4846179
KEGGimem:Memar_1865

Similar proteinsi

Entry informationi

Entry nameiDNLI_METMJ
AccessioniPrimary (citable) accession number: A3CWP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 20, 2007
Last modified: July 18, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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