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Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Streptococcus sanguinis (strain SK36)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.UniRule annotation

Activity regulationi

Allosterically activated by GTP.UniRule annotation

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uracil.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uracil phosphoribosyltransferase (upp)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uracil, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei795-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1
Binding sitei1045-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1
Binding sitei194Uracil; via amide nitrogenUniRule annotation1
Binding sitei2005-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Glycosyltransferase, Transferase
LigandGTP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSAN388919:SSA_1732-MONOMER
UniPathwayi
UPA00574;UER00636

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Alternative name(s):
UMP pyrophosphorylaseUniRule annotation
UPRTaseUniRule annotation
Gene namesi
Name:uppUniRule annotation
Ordered Locus Names:SSA_1732
OrganismiStreptococcus sanguinis (strain SK36)
Taxonomic identifieri388919 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002148 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000538001 – 209Uracil phosphoribosyltransferaseAdd BLAST209

Interactioni

Protein-protein interaction databases

STRINGi388919.SSA_1732

Structurei

3D structure databases

ProteinModelPortaliA3CPK9
SMRiA3CPK9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni131 – 1395-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation9
Regioni199 – 201Uracil bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ5 Bacteria
COG0035 LUCA
HOGENOMiHOG000262754
KOiK00761
OMAiRICGYEI

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01218_B Upp_B, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR034332 Upp_B
IPR005765 Ura_phspho_trans
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01091 upp, 1 hit

Sequencei

Sequence statusi: Complete.

A3CPK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKLEVIAHP LIQHKLSILR RTDTSTKAFR ELVDEIAMLM GYEVLRDLPL
60 70 80 90 100
EDVEIETPIT KTVQKQIAGK KLAIVPILRA GIGMVDGLLS LVPAAKVGHI
110 120 130 140 150
GMYRDEETLK PVEYLVKLPE DIDQRQIFVV DPMLATGGSA ILAVDSLKKR
160 170 180 190 200
GASHITFVCL VSAPEGVKAL QEAHPDVDIF TAALDDHLND HGYIVPGLGD

AGDRLFGTK
Length:209
Mass (Da):22,764
Last modified:March 20, 2007 - v1
Checksum:i21D9120ABECAABDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000387 Genomic DNA Translation: ABN45114.1
RefSeqiWP_002894672.1, NC_009009.1
YP_001035664.1, NC_009009.1

Genome annotation databases

EnsemblBacteriaiABN45114; ABN45114; SSA_1732
GeneIDi4806037
KEGGissa:SSA_1732
PATRICifig|388919.9.peg.1641

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000387 Genomic DNA Translation: ABN45114.1
RefSeqiWP_002894672.1, NC_009009.1
YP_001035664.1, NC_009009.1

3D structure databases

ProteinModelPortaliA3CPK9
SMRiA3CPK9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi388919.SSA_1732

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN45114; ABN45114; SSA_1732
GeneIDi4806037
KEGGissa:SSA_1732
PATRICifig|388919.9.peg.1641

Phylogenomic databases

eggNOGiENOG4105CZ5 Bacteria
COG0035 LUCA
HOGENOMiHOG000262754
KOiK00761
OMAiRICGYEI

Enzyme and pathway databases

UniPathwayi
UPA00574;UER00636

BioCyciSSAN388919:SSA_1732-MONOMER

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01218_B Upp_B, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR034332 Upp_B
IPR005765 Ura_phspho_trans
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01091 upp, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUPP_STRSV
AccessioniPrimary (citable) accession number: A3CPK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 20, 2007
Last modified: October 10, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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