We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - A2YMV6 (WNK1_ORYSI)
Protein
Probable serine/threonine-protein kinase WNK1
Gene
WNK1
Organism
Oryza sativa subsp. indica (Rice)
Status
Functioni
Caution
Was named WNK/'with no lysine(K)' because key residues for catalysis, including the lysine involved in ATP binding, are either not conserved or differ compared to the residues described in other kinase family proteins.By similarity
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 157 | ATPBy similarity | 1 | |
Active sitei | 174 | Proton acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 107 – 110 | ATPBy similarity | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB-KW
- protein serine kinase activity Source: RHEA
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Probable serine/threonine-protein kinase WNK1 (EC:2.7.11.1)Short name: OsWNK1 Alternative name(s): Mitogen-activated protein kinase kinase 1 Protein kinase with no lysine 1 |
Gene namesi | Name:WNK1 Synonyms:MEK1 ORF Names:OsI_025649 |
Organismi | Oryza sativa subsp. indica (Rice) |
Taxonomic identifieri | 39946 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000351671 | 1 – 704 | Probable serine/threonine-protein kinase WNK1Add BLAST | 704 |
Proteomic databases
PRIDEi | A2YMV6 |
Expressioni
Inductioni
By fungal elicitor.1 Publication
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 284 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 258 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 499 – 519 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.PROSITE-ProRule annotation
Phylogenomic databases
HOGENOMi | CLU_000288_142_2_1 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: A2YMV6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMGPKANAAA AGDLPEYAEV DPTGRYGRYN DVLGKGASKT VYRAFDEYQG
60 70 80 90 100
MEVAWNQVKL HDFLQSPEDL ERLYCEIHLL KTLKHRNIMK FYTSWVDVSR
110 120 130 140 150
RNINFITEMF TSGTLRQYRQ KHMRVNIWAV KHWCRQILSG LLYLHSHDPP
160 170 180 190 200
IIHRDLKCDN IFVNGNQGEV KIGDLGLAAI LRKSHAVHCV GTPEFMAPEV
210 220 230 240 250
YEEEYNELVD IYSFGMCVLE MVTFEYPYSE CTHPVQIYKK VISGTKPEAL
260 270 280 290 300
YKVKDPMVRQ FVEKCLATAS RRLSARELLK DPFLQVDDLV FCPGDGDYSL
310 320 330 340 350
MNYLRQPYLE HAYSNVSMMS NGLSESIDED TPTEDRWDCE DDDIKADGID
360 370 380 390 400
LFNGHEDEPL GNVDITIKGR KSEDGSIFLR LRIADNDGHV RNIYFPFDIE
410 420 430 440 450
ADTALSVATE MVAELDITDH EVTRIAEMID GEVSALVPDW RPGPGIEESQ
460 470 480 490 500
DTTYCHNCGS NVSSCGSLYA YMSSAARGCQ CAELHGRFEE ITFQANGEQT
510 520 530 540 550
DLQDSGGSSD DGGGQTQHVK DQEAVHSNGF VQMGRRGPPD QFCFSSFQEQ
560 570 580 590 600
SCSPRHYEYD TSLQAKGFDM KHEVKMAKYK ARKMAHLRRA IHPSLDFDNL
610 620 630 640 650
NGERRMKSSL NKLQSFHIGK NHNFRIPTCE RSPGARDAEE DPDIFNLAYH
660 670 680 690 700
SRHPDPGAQR ARHCEVDAQS SPDLMFTARS YYTGAQLPTN LPRTKSVTLN
AVDA
Sequence cautioni
The sequence AAC32599 differs from that shown. Reason: Erroneous initiation.Curated
The sequence ABH07431 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAZ04417 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 278 | L → V in AAC32599 (PubMed:10755311).Curated | 1 | |
Sequence conflicti | 297 | D → N in AAC32599 (PubMed:10755311).Curated | 1 | |
Sequence conflicti | 310 | E → Q in AAC32599 (PubMed:10755311).Curated | 1 | |
Sequence conflicti | 315 | N → T in AAC32599 (PubMed:10755311).Curated | 1 | |
Sequence conflicti | 316 | V → A in ABH07431 (Ref. 2) Curated | 1 | |
Sequence conflicti | 331 | T → S in AAC32599 (PubMed:10755311).Curated | 1 | |
Sequence conflicti | 374 | D → N in ABH07431 (Ref. 2) Curated | 1 | |
Sequence conflicti | 474 | S → C in AAC32599 (PubMed:10755311).Curated | 1 | |
Sequence conflicti | 480 | Q → H in AAC32599 (PubMed:10755311).Curated | 1 | |
Sequence conflicti | 483 | E → D in AAC32599 (PubMed:10755311).Curated | 1 | |
Sequence conflicti | 490 | E → D in AAC32599 (PubMed:10755311).Curated | 1 | |
Sequence conflicti | 521 – 522 | DQ → NK in EAZ04417 (PubMed:15685292).Curated | 2 | |
Sequence conflicti | 535 – 539 | RRGPP → TTRPR in AAC32599 (PubMed:10755311).Curated | 5 | |
Sequence conflicti | 590 | A → G in AAC32599 (PubMed:10755311).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035534 | 649 – 654 | YHSRHP → PKGPAL in isoform 2. 2 Publications | 6 | |
Alternative sequenceiVSP_035535 | 655 – 704 | Missing in isoform 2. 2 PublicationsAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF080436 mRNA Translation: AAC32599.1 Different initiation. DQ837532 mRNA Translation: ABH07431.1 Different initiation. CM000132 Genomic DNA Translation: EAZ04417.1 Different initiation. |
PIRi | T02951 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF080436 mRNA Translation: AAC32599.1 Different initiation. DQ837532 mRNA Translation: ABH07431.1 Different initiation. CM000132 Genomic DNA Translation: EAZ04417.1 Different initiation. |
PIRi | T02951 |
3D structure databases
SMRi | A2YMV6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 39946.A2YMV6 |
Proteomic databases
PRIDEi | A2YMV6 |
Phylogenomic databases
HOGENOMi | CLU_000288_142_2_1 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | WNK1_ORYSI | |
Accessioni | A2YMV6Primary (citable) accession number: A2YMV6 Secondary accession number(s): O81637, Q0PGM8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 14, 2008 |
Last sequence update: | October 14, 2008 | |
Last modified: | February 23, 2022 | |
This is version 70 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families