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UniProtKB - A2YH41 (ATR_ORYSI)

Entry version 67 (10 Feb 2021)
Sequence version 2 (24 Jul 2007)
Previous versions | rss
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Protein

Serine/threonine-protein kinase ATR

Gene

OsI_023634

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable serine/threonine kinase. Seems to play a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, DNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase ATR (EC:2.7.11.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:OsI_023634
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryza sativa subsp. indica (Rice)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri39946 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007015 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002958951 – 2710Serine/threonine-protein kinase ATRAdd BLAST2710

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		A2YH41

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1647 – 2257FATPROSITE-ProRule annotationAdd BLAST611
Domaini2392 – 2640PI3K/PI4KPROSITE-ProRule annotationAdd BLAST249
Domaini2678 – 2710FATCPROSITE-ProRule annotationAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. ATM subfamily.Curated

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR012993, UME

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF08064, UME, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SM00802, UME, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2YH41-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANFSSHIQE LRELIAASST TTSTSAPASV HFEVKLREVL PNLLRDYVVP 
        60         70         80         90        100
SSPTADGREA TAVLKLLSYT AGKFPGVFFH GRAADVIRVI GRVLPFFAEP 
       110        120        130        140        150
NFRSRHEIIF DTVWSLLSLL RTGDREAYRQ FFLDVMVAVQ DVLYVVASMH 
       160        170        180        190        200
GDRPSGVLTE RYLVKCLCGS FSDILDSPGI FSDLPDSCQP KNGPGVLVDL 
       210        220        230        240        250
TGETRWRPFA TMLIKLVNKC LADGTLYVEG LVNMPFVSAA CSIICYGDES 
       260        270        280        290        300
LHKVCFDFAR IVATVITVEI LPVENIIRSI MCILSQDVNG LSDIRDADYD 
       310        320        330        340        350
FSMGACLHAL HSSCPGYIVA ITASDIVNVF QRAVHTSRSS ELQVAMCNAY 
       360        370        380        390        400
KRIVELCSPR VWKPEILLKL LCLPKPCAKL IECIRLVVDK SGQSFLSSDD 
       410        420        430        440        450
RDDGSSLLAK SEGLDLPKVG QKRIALDEEN SFPKRLKMTE PRFSSGSFMV 
       460        470        480        490        500
DELSAGVGQE LEKDHGCDFR VQLYSLINCL SPDNHMAYPL EPAIAIQVLS 
       510        520        530        540        550
LLCLSLSVYP KTNLFSRISK QVLSWIPWIC KQTTKICMFS FDVSLYFEAV 
       560        570        580        590        600
QTVMLLQSFL PGHTKLFEDE PLLIGNGCTD FEYPRYADLI NLLKLVSDDG 
       610        620        630        640        650
YLTSQTCSEK LKCLAVQIIA KIGSRQNAEC DLQVLELAIQ SETGELQNEA 
       660        670        680        690        700
LMSLPIIVLY SGPRMLGAMF RKLETIGTLG CKKLWKSIAI SLGFLSCLNG 
       710        720        730        740        750
TTDCTDKVGN HCKLFLAKHC EQPILTLNLL RGFWCPQCDV RTVHIEDQVP 
       760        770        780        790        800
IVDIALSEDK NIDFKINMFK AHSLFFKFLY AETSEECIVS IVEVLPRILK 
       810        820        830        840        850
HSSRDVLLDM KFQWVQCVDF LLLHEMKAVR DAFSSVVSCF LETNAMDILF 
       860        870        880        890        900
SDGTGMSGGT SRVKFMDKIK SAFTEAEDPQ ILLTLLESTA AIVKASDIHG 
       910        920        930        940        950
EVFFCSFVLL IGQLGNHDYI VRVTALRLLQ RCCTYCFKGG LELFLSKYFH 
       960        970        980        990       1000
VRDNLYDYLS SRLLTHPVVI SEFAESVLGV KTEELIRRMV PSIIPKLIVS 
      1010       1020       1030       1040       1050
HQNNDQAVVT LNELASHLNS ELVPLIVNSL PKVLSFALFY EDGQHLSSVL 
      1060       1070       1080       1090       1100
QFYHTETGTD SKEIFSAALP TLLDEIICFP GESDQIETDR RMAKISPTIQ 
      1110       1120       1130       1140       1150
NIARILIGND NLPEFLKNDF VRLLNSIDKK MLHSSDVNLQ KQALQRIRKL 
      1160       1170       1180       1190       1200
VEMMGPYLST HAPKIMVLLI FAIDKETLQM DGLDVLHFFI KRLAEVSCTS 
      1210       1220       1230       1240       1250
IKYVMSQVVA AFIPSLERCR ERPLVHLGKI VEILEELVVK NIILLKQHIR 
      1260       1270       1280       1290       1300
ELPLLPSLPS LSGVNKVIQE ARGLMTLQDH LKDAVNGLNH ESLNVRYMVA 
      1310       1320       1330       1340       1350
CELNKLFNDR REDITSLIIG EDIADLDIIS SLIMSLLKGC AEESRTVVGQ 
      1360       1370       1380       1390       1400
RLKLVCADCL GALGAVDPAK FKVMSCERFK IECSDDDLIF ELIHKHLARA 
      1410       1420       1430       1440       1450
FRAASDTTVQ DSAALAIQEL LKLSGCQSLP NESSSCKMSK RGQKLWGRFS 
      1460       1470       1480       1490       1500
SYVKEIIAPC LTSRFHLPSV NDATLAGPIY RPTMSFRRWI YYWIRKLTSH 
      1510       1520       1530       1540       1550
ATGSRSGIFG ACRGIVRHDM PTAIYLLPYL VLNVVCYGTP EARQSITEEI 
      1560       1570       1580       1590       1600
LSVLNAAASE SSGAIVHGIT GGQSEVCIQA VFTLLDNLGQ WVDDLKQEIA 
      1610       1620       1630       1640       1650
LSQSNYAMAG RQGGKLRDES NSMYDQDQLL VQCSNVAELL AAIPKVTLAK 
      1660       1670       1680       1690       1700
ASFRCQAHAR ALMYFESHVR EKSGSSNPAA DCSGAFSDDD ISFLMEIYGG 
      1710       1720       1730       1740       1750
LDEPDGLLGL ANLRKSSTLQ DQLIINEKAG NWAEVLTLCE QSLQMEPDSV 
      1760       1770       1780       1790       1800
HRHCDVLNCL LNMCHLQAMI AHVDGLVYRI PQSKKTWCMQ GVQAAWRLGR 
      1810       1820       1830       1840       1850
WDLMDEYLAE ADKGLVCRSS ENNASFDMGL AKIFNAMMKK DQFMVAEKIA 
      1860       1870       1880       1890       1900
QSKQALLVPL AAAGMDSYMR AYPYIVKLHM LRELEDFNSL LGDESFLEKP 
      1910       1920       1930       1940       1950
FAADDPKFLK LTKDWENRLR CTQPSLWARE PLLAFRRMVY NLSHMNAQAG 
      1960       1970       1980       1990       2000
NCWLQYARLC RLAGHYETAH RAILEADASG APNAHMEKAK YLWNIRKSDS 
      2010       2020       2030       2040       2050
AIAELQQTLL NMPADVLGPT VLSSLSSLSL ALPNAPLSVT QASKENPDVS 
      2060       2070       2080       2090       2100
KTLLLYTRWI HYTGQKQSND IKSLYSRVAD LRPKWEKGFF CIAKFYDDLL 
      2110       2120       2130       2140       2150
VDARRRQEDK KIASGVGPVP PSSTGSLTTA TEEKPWWDML PVVLIQYARG 
      2160       2170       2180       2190       2200
LHRGHKNLFQ ALPRLLTLWF EFGSIYIQDG SSFNKPMKEV HIRLLGIMRG 
      2210       2220       2230       2240       2250
CLKDLPPYQW LTVLSQLISR ICHQNIEVVK LVKCIVTSIL REYPQQALWM 
      2260       2270       2280       2290       2300
MAAVSKSTVA ARRDAAAEIL QSAKKGSRRG SDSNALFMQF PSLIDHLIKL 
      2310       2320       2330       2340       2350
CFHPGQPKAR AINISTEFSS LKRMMPLGII LPIQQALTVT LPSYDTNMTD 
      2360       2370       2380       2390       2400
QSTFRPFSVS EHPTIAGIAD DAEILNSLQK PKKVVFIGSD GISRPFLCKP 
      2410       2420       2430       2440       2450
KDDLRKDSRM MEFNAMINRL LSKVPESRRR KLYIRTFAVV PLTEDCGMVE 
      2460       2470       2480       2490       2500
WVPNTRGLRQ ILQDIYITCG KFDRMKTNPQ IKKIYDQLQG KMPEEMLKAK 
      2510       2520       2530       2540       2550
ILPMFPPVFH KWFLTTFSEP AAWIRARAAY AHTTAVWSMV GHIVGLGDRH 
      2560       2570       2580       2590       2600
GENILLDSTT GDCIHVDFSC LFDKGLLLEK PEVVPFRFTQ NMVDGLGITG 
      2610       2620       2630       2640       2650
YEGVFVKVCE ITLSVLRTHK EALMTVLETF IHDPLVEWTK SHKSSGVEVR 
      2660       2670       2680       2690       2700
NPHAQRAISN ITERLQGVVV GVNAAPSLPL SVEGQARRLI AEAVSHSNLG 
      2710
KMYVWWMAWF
Length:2,710
Mass (Da):303,493
Last modified:July 24, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA4B9B8FDE6FF961
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CM000131 Genomic DNA No translation available.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000131 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PRIDEiA2YH41

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR012993, UME
PfamiView protein in Pfam
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF08064, UME, 1 hit
SMARTiView protein in SMART
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SM00802, UME, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATR_ORYSI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2YH41
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: February 10, 2021
This is version 67 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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