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Entry version 67 (10 Feb 2021)
Sequence version 2 (24 Jul 2007)
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Protein

Serine/threonine-protein kinase ATR

Gene

OsI_023634

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable serine/threonine kinase. Seems to play a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, DNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase ATR (EC:2.7.11.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:OsI_023634
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryza sativa subsp. indica (Rice)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri39946 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007015 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002958951 – 2710Serine/threonine-protein kinase ATRAdd BLAST2710

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A2YH41

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1647 – 2257FATPROSITE-ProRule annotationAdd BLAST611
Domaini2392 – 2640PI3K/PI4KPROSITE-ProRule annotationAdd BLAST249
Domaini2678 – 2710FATCPROSITE-ProRule annotationAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. ATM subfamily.Curated

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR012993, UME

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF08064, UME, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SM00802, UME, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2YH41-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANFSSHIQE LRELIAASST TTSTSAPASV HFEVKLREVL PNLLRDYVVP
60 70 80 90 100
SSPTADGREA TAVLKLLSYT AGKFPGVFFH GRAADVIRVI GRVLPFFAEP
110 120 130 140 150
NFRSRHEIIF DTVWSLLSLL RTGDREAYRQ FFLDVMVAVQ DVLYVVASMH
160 170 180 190 200
GDRPSGVLTE RYLVKCLCGS FSDILDSPGI FSDLPDSCQP KNGPGVLVDL
210 220 230 240 250
TGETRWRPFA TMLIKLVNKC LADGTLYVEG LVNMPFVSAA CSIICYGDES
260 270 280 290 300
LHKVCFDFAR IVATVITVEI LPVENIIRSI MCILSQDVNG LSDIRDADYD
310 320 330 340 350
FSMGACLHAL HSSCPGYIVA ITASDIVNVF QRAVHTSRSS ELQVAMCNAY
360 370 380 390 400
KRIVELCSPR VWKPEILLKL LCLPKPCAKL IECIRLVVDK SGQSFLSSDD
410 420 430 440 450
RDDGSSLLAK SEGLDLPKVG QKRIALDEEN SFPKRLKMTE PRFSSGSFMV
460 470 480 490 500
DELSAGVGQE LEKDHGCDFR VQLYSLINCL SPDNHMAYPL EPAIAIQVLS
510 520 530 540 550
LLCLSLSVYP KTNLFSRISK QVLSWIPWIC KQTTKICMFS FDVSLYFEAV
560 570 580 590 600
QTVMLLQSFL PGHTKLFEDE PLLIGNGCTD FEYPRYADLI NLLKLVSDDG
610 620 630 640 650
YLTSQTCSEK LKCLAVQIIA KIGSRQNAEC DLQVLELAIQ SETGELQNEA
660 670 680 690 700
LMSLPIIVLY SGPRMLGAMF RKLETIGTLG CKKLWKSIAI SLGFLSCLNG
710 720 730 740 750
TTDCTDKVGN HCKLFLAKHC EQPILTLNLL RGFWCPQCDV RTVHIEDQVP
760 770 780 790 800
IVDIALSEDK NIDFKINMFK AHSLFFKFLY AETSEECIVS IVEVLPRILK
810 820 830 840 850
HSSRDVLLDM KFQWVQCVDF LLLHEMKAVR DAFSSVVSCF LETNAMDILF
860 870 880 890 900
SDGTGMSGGT SRVKFMDKIK SAFTEAEDPQ ILLTLLESTA AIVKASDIHG
910 920 930 940 950
EVFFCSFVLL IGQLGNHDYI VRVTALRLLQ RCCTYCFKGG LELFLSKYFH
960 970 980 990 1000
VRDNLYDYLS SRLLTHPVVI SEFAESVLGV KTEELIRRMV PSIIPKLIVS
1010 1020 1030 1040 1050
HQNNDQAVVT LNELASHLNS ELVPLIVNSL PKVLSFALFY EDGQHLSSVL
1060 1070 1080 1090 1100
QFYHTETGTD SKEIFSAALP TLLDEIICFP GESDQIETDR RMAKISPTIQ
1110 1120 1130 1140 1150
NIARILIGND NLPEFLKNDF VRLLNSIDKK MLHSSDVNLQ KQALQRIRKL
1160 1170 1180 1190 1200
VEMMGPYLST HAPKIMVLLI FAIDKETLQM DGLDVLHFFI KRLAEVSCTS
1210 1220 1230 1240 1250
IKYVMSQVVA AFIPSLERCR ERPLVHLGKI VEILEELVVK NIILLKQHIR
1260 1270 1280 1290 1300
ELPLLPSLPS LSGVNKVIQE ARGLMTLQDH LKDAVNGLNH ESLNVRYMVA
1310 1320 1330 1340 1350
CELNKLFNDR REDITSLIIG EDIADLDIIS SLIMSLLKGC AEESRTVVGQ
1360 1370 1380 1390 1400
RLKLVCADCL GALGAVDPAK FKVMSCERFK IECSDDDLIF ELIHKHLARA
1410 1420 1430 1440 1450
FRAASDTTVQ DSAALAIQEL LKLSGCQSLP NESSSCKMSK RGQKLWGRFS
1460 1470 1480 1490 1500
SYVKEIIAPC LTSRFHLPSV NDATLAGPIY RPTMSFRRWI YYWIRKLTSH
1510 1520 1530 1540 1550
ATGSRSGIFG ACRGIVRHDM PTAIYLLPYL VLNVVCYGTP EARQSITEEI
1560 1570 1580 1590 1600
LSVLNAAASE SSGAIVHGIT GGQSEVCIQA VFTLLDNLGQ WVDDLKQEIA
1610 1620 1630 1640 1650
LSQSNYAMAG RQGGKLRDES NSMYDQDQLL VQCSNVAELL AAIPKVTLAK
1660 1670 1680 1690 1700
ASFRCQAHAR ALMYFESHVR EKSGSSNPAA DCSGAFSDDD ISFLMEIYGG
1710 1720 1730 1740 1750
LDEPDGLLGL ANLRKSSTLQ DQLIINEKAG NWAEVLTLCE QSLQMEPDSV
1760 1770 1780 1790 1800
HRHCDVLNCL LNMCHLQAMI AHVDGLVYRI PQSKKTWCMQ GVQAAWRLGR
1810 1820 1830 1840 1850
WDLMDEYLAE ADKGLVCRSS ENNASFDMGL AKIFNAMMKK DQFMVAEKIA
1860 1870 1880 1890 1900
QSKQALLVPL AAAGMDSYMR AYPYIVKLHM LRELEDFNSL LGDESFLEKP
1910 1920 1930 1940 1950
FAADDPKFLK LTKDWENRLR CTQPSLWARE PLLAFRRMVY NLSHMNAQAG
1960 1970 1980 1990 2000
NCWLQYARLC RLAGHYETAH RAILEADASG APNAHMEKAK YLWNIRKSDS
2010 2020 2030 2040 2050
AIAELQQTLL NMPADVLGPT VLSSLSSLSL ALPNAPLSVT QASKENPDVS
2060 2070 2080 2090 2100
KTLLLYTRWI HYTGQKQSND IKSLYSRVAD LRPKWEKGFF CIAKFYDDLL
2110 2120 2130 2140 2150
VDARRRQEDK KIASGVGPVP PSSTGSLTTA TEEKPWWDML PVVLIQYARG
2160 2170 2180 2190 2200
LHRGHKNLFQ ALPRLLTLWF EFGSIYIQDG SSFNKPMKEV HIRLLGIMRG
2210 2220 2230 2240 2250
CLKDLPPYQW LTVLSQLISR ICHQNIEVVK LVKCIVTSIL REYPQQALWM
2260 2270 2280 2290 2300
MAAVSKSTVA ARRDAAAEIL QSAKKGSRRG SDSNALFMQF PSLIDHLIKL
2310 2320 2330 2340 2350
CFHPGQPKAR AINISTEFSS LKRMMPLGII LPIQQALTVT LPSYDTNMTD
2360 2370 2380 2390 2400
QSTFRPFSVS EHPTIAGIAD DAEILNSLQK PKKVVFIGSD GISRPFLCKP
2410 2420 2430 2440 2450
KDDLRKDSRM MEFNAMINRL LSKVPESRRR KLYIRTFAVV PLTEDCGMVE
2460 2470 2480 2490 2500
WVPNTRGLRQ ILQDIYITCG KFDRMKTNPQ IKKIYDQLQG KMPEEMLKAK
2510 2520 2530 2540 2550
ILPMFPPVFH KWFLTTFSEP AAWIRARAAY AHTTAVWSMV GHIVGLGDRH
2560 2570 2580 2590 2600
GENILLDSTT GDCIHVDFSC LFDKGLLLEK PEVVPFRFTQ NMVDGLGITG
2610 2620 2630 2640 2650
YEGVFVKVCE ITLSVLRTHK EALMTVLETF IHDPLVEWTK SHKSSGVEVR
2660 2670 2680 2690 2700
NPHAQRAISN ITERLQGVVV GVNAAPSLPL SVEGQARRLI AEAVSHSNLG
2710
KMYVWWMAWF
Length:2,710
Mass (Da):303,493
Last modified:July 24, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA4B9B8FDE6FF961
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CM000131 Genomic DNA No translation available.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000131 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiA2YH41

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR012993, UME
PfamiView protein in Pfam
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF08064, UME, 1 hit
SMARTiView protein in SMART
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SM00802, UME, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATR_ORYSI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2YH41
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: February 10, 2021
This is version 67 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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