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Protein

Probable histone H2A.6

Gene

OsI_017523

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-OSA-212300 PRC2 methylates histones and DNA
R-OSA-2299718 Condensation of Prophase Chromosomes
R-OSA-2559580 Oxidative Stress Induced Senescence
R-OSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-OSA-5578749 Transcriptional regulation by small RNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Probable histone H2A.6
Gene namesi
ORF Names:OsI_017523
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000007015 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002961241 – 156Probable histone H2A.6Add BLAST156

Proteomic databases

PRIDEiA2XZN0

Expressioni

Gene expression databases

ExpressionAtlasiA2XZN0 differential

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA2XZN0
SMRiA2XZN0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi149 – 152SPKK motif4

Domaini

Contains one SPKK motif which may interact with the minor groove of A/T-rich DNA sites. Phosphorylation of this motif may regulate DNA binding. This motif is reiterated in both termini of histone H1 and in the N-terminus of sea urchin histones H2B, but its presence in the C-terminus seems to be unique to plant H2A.

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

HOGENOMiHOG000234652

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

Sequencei

Sequence statusi: Complete.

A2XZN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVGVGGKAA KKAVGRKLGG PKKKPVSRSV KAGLQFPVGR IGRYLKKGRY
60 70 80 90 100
AQRVGTGAPV YLAAVLEYLA AEVLELAGNA ARDNKKNRII PRHVLLAIRN
110 120 130 140 150
DEELGKLLAG VTIAHGGVLP NINPVLLPKK TAEKADKPAK ASKDKAAKSP

KKQARS
Length:156
Mass (Da):16,501
Last modified:July 24, 2007 - v2
Checksum:iB7A2E355D3219474
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000130 Genomic DNA No translation available.

Genome annotation databases

EnsemblPlantsiOs05t0113900-01; Os05t0113900-01; Os05g0113900
GrameneiOs05t0113900-01; Os05t0113900-01; Os05g0113900

Similar proteinsi

Entry informationi

Entry nameiH2A6_ORYSI
AccessioniPrimary (citable) accession number: A2XZN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: May 23, 2018
This is version 54 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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