We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - A2XX73 (ICMT_ORYSI)
Protein
Probable protein-S-isoprenylcysteine O-methyltransferase
Gene
ICMT
Organism
Oryza sativa subsp. indica (Rice)
Status
Functioni
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. Carboxyl methylation is a reversible and potentially regulated step in the post-translational modification of prenylated proteins (By similarity).
By similarityCatalytic activityi
- [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteineEC:2.1.1.100
Cofactori
Zn2+By similarityNote: Divalent metal cations. Probably Zn2+.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 118 | S-adenosyl-L-methionineBy similarity | 1 | |
Binding sitei | 160 | SubstrateBy similarity | 1 | |
Binding sitei | 164 | S-adenosyl-L-methionineBy similarity | 1 |
GO - Molecular functioni
- protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Methyltransferase, Transferase |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: Probable protein-S-isoprenylcysteine O-methyltransferase (EC:2.1.1.100)Alternative name(s): Isoprenylcysteine carboxylmethyltransferase Prenylated protein carboxyl methyltransferase Prenylcysteine carboxyl methyltransferase |
Gene namesi | Name:ICMT ORF Names:B0403H10-OSIGBa0105A11.23, OsI_016666 |
Organismi | Oryza sativa subsp. indica (Rice) |
Taxonomic identifieri | 39946 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 8 – 28 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 45 – 65 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 66 – 86 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 129 – 149 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000356252 | 1 – 191 | Probable protein-S-isoprenylcysteine O-methyltransferaseAdd BLAST | 191 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 110 – 113 | S-adenosyl-L-methionine bindingBy similarity | 4 | |
Regioni | 123 – 126 | S-adenosyl-L-methionine bindingBy similarity | 4 |
Sequence similaritiesi
Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_065200_0_2_1 |
OMAi | FFYWGLG |
Family and domain databases
InterProi | View protein in InterPro IPR007269, ICMT_MeTrfase IPR025770, PPMT_MeTrfase |
Pfami | View protein in Pfam PF04140, ICMT, 1 hit |
PROSITEi | View protein in PROSITE PS51564, SAM_ICMT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A2XX73-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAARAQAWLF AAALVIFHGS EYVLAAAFHG RRNVTATSLL ISKQYVLAMS
60 70 80 90 100
FAMLEHLTEA LLFPELKEYW FVSYVGLVMV IIGEVIRKLA VVTAGRSFTH
110 120 130 140 150
VIRIHYEDQH KLITHGVYRL MRHPGYSGFL IWAVGTQVML CNPLSTVAFT
160 170 180 190
LVLWRFFSKR IPYEEFFLRQ FFGREYEEYA QKVHSGLPFI E
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB8ATT2 | B8ATT2_ORYSI | Protein-S-isoprenylcysteine O-methy... | OsI_17275 | 191 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR855228 Genomic DNA Translation: CAH67871.1 CM000129 Genomic DNA No translation available. |
Genome annotation databases
EnsemblPlantsi | BGIOSGA017059-TA; BGIOSGA017059-PA; BGIOSGA017059 |
Gramenei | BGIOSGA017059-TA; BGIOSGA017059-PA; BGIOSGA017059 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR855228 Genomic DNA Translation: CAH67871.1 CM000129 Genomic DNA No translation available. |
3D structure databases
SMRi | A2XX73 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 39946.A2XX73 |
Genome annotation databases
EnsemblPlantsi | BGIOSGA017059-TA; BGIOSGA017059-PA; BGIOSGA017059 |
Gramenei | BGIOSGA017059-TA; BGIOSGA017059-PA; BGIOSGA017059 |
Phylogenomic databases
HOGENOMi | CLU_065200_0_2_1 |
OMAi | FFYWGLG |
Family and domain databases
InterProi | View protein in InterPro IPR007269, ICMT_MeTrfase IPR025770, PPMT_MeTrfase |
Pfami | View protein in Pfam PF04140, ICMT, 1 hit |
PROSITEi | View protein in PROSITE PS51564, SAM_ICMT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ICMT_ORYSI | |
Accessioni | A2XX73Primary (citable) accession number: A2XX73 Secondary accession number(s): Q01HS5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 16, 2008 |
Last sequence update: | December 16, 2008 | |
Last modified: | February 23, 2022 | |
This is version 71 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families