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Protein

E3 ubiquitin-protein ligase BRE1-like 1

Gene

BRE1A

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1. H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and maybe H3K79me. It thereby plays a central role in histone code and gene regulation. Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBC2/RAD6.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri832 – 871RING-typePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Transferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase BRE1-like 1 (EC:2.3.2.27By similarity)
Alternative name(s):
RING-type E3 ubiquitin transferase BRE1-like 1Curated
Gene namesi
Name:BRE1A
ORF Names:OsI_16895
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000007015 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002931111 – 884E3 ubiquitin-protein ligase BRE1-like 1Add BLAST884

Proteomic databases

PRIDEiA2XW69

Expressioni

Gene expression databases

ExpressionAtlasiA2XW69 differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi39946.BGIOSGA014597-PA

Structurei

3D structure databases

ProteinModelPortaliA2XW69
SMRiA2XW69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili49 – 86Sequence analysisAdd BLAST38
Coiled coili216 – 541Sequence analysisAdd BLAST326
Coiled coili580 – 663Sequence analysisAdd BLAST84
Coiled coili696 – 762Sequence analysisAdd BLAST67
Coiled coili789 – 827Sequence analysisAdd BLAST39

Domaini

The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.By similarity

Sequence similaritiesi

Belongs to the BRE1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri832 – 871RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG0978 Eukaryota
ENOG410Y5C6 LUCA
HOGENOMiHOG000006004
OMAiNRYWNQF
OrthoDBiEOG0936048P

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR013956 E3_ubiquit_lig_Bre1
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR23163 PTHR23163, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

A2XW69-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSTGEPDRK RRLSSSVAPG GGAPVSPAKR LAVAPTSEDK KLDFTVLKYK
60 70 80 90 100
NQKLSEQLEA HKFEYRALEN KFAGLKEKQR THNETLSLVN SSWEQLVADL
110 120 130 140 150
KSRSFCKSGS PNSSPGSGHN NVQKDGTCAP IERDTLRSLV ESGATESSGC
160 170 180 190 200
LPGCHLGSDA PPLHLSTANA LGDIFFPSSD LLQANEECAL AALTKLPEND
210 220 230 240 250
RSKQLQSTSS NLLSSLNNVV QALSNLQLKH KQLAEDYQNQ RDSSARKRAE
260 270 280 290 300
HRRLKEELAS AASELEETNY KLAALKAQRD NTQGARIPYP TLGNKSMPED
310 320 330 340 350
KVRDKQREMQ DLEATHKELS ELISKRLVEI KRLHEERIEI LNKIATFQNI
360 370 380 390 400
LMDFKSIRSS KAFQLVNDRL QKSQAELDHY QTLLEKLQVD KDKFVWQERQ
410 420 430 440 450
FNLKVDLAEI PERVSTYCES SIADLKKDIQ KLRDEKNMLI LKLEEASREP
460 470 480 490 500
GRNQVITKFK ALVSSIPREM GAMQSEMTKH KEASLELNSL RAEVHSLSRI
510 520 530 540 550
LSRKERDNEE ASCRSARAGS DITQLQSVIS DLKQTNKELK LFADMYKRES
560 570 580 590 600
TDSREIMESR DREFLEWAHV HALKSSLDES KLEQRVKAAN EAEAITQQRL
610 620 630 640 650
ATAEAEIAES GQKLGTSRKD LVSLSHMLKS KQEECEAYRV EVECIGQAYE
660 670 680 690 700
DIQAQNQQLL QQIIERDDDN TKIFMEGVKA KQTQDALHLE TYSLRRNLQQ
710 720 730 740 750
ESSLMDLYNQ KIVSLEDQLK MWSDRVGKLQ EDGWQQSVSL SNYQRKLVDV
760 770 780 790 800
HRDAQKLMQS LDGIQANVGS SRLEVADLLI ELEKERFSKK RIEDDLEVMS
810 820 830 840 850
RKASSLRAKA RESAVLEKLR HEVKEYRGIL KCGICHDRQK EVVITKCYHL
860 870 880
FCNQCIQKSL GNRQRRCPSC SLSFGANDVK PIYI
Length:884
Mass (Da):100,399
Last modified:July 10, 2007 - v2
Checksum:i2B2CB3E6D8F58A78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000129 Genomic DNA Translation: EEC77758.1

Genome annotation databases

EnsemblPlantsiBGIOSGA014597-TA; BGIOSGA014597-PA; BGIOSGA014597
GrameneiBGIOSGA014597-TA; BGIOSGA014597-PA; BGIOSGA014597

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000129 Genomic DNA Translation: EEC77758.1

3D structure databases

ProteinModelPortaliA2XW69
SMRiA2XW69
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39946.BGIOSGA014597-PA

Proteomic databases

PRIDEiA2XW69

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiBGIOSGA014597-TA; BGIOSGA014597-PA; BGIOSGA014597
GrameneiBGIOSGA014597-TA; BGIOSGA014597-PA; BGIOSGA014597

Phylogenomic databases

eggNOGiKOG0978 Eukaryota
ENOG410Y5C6 LUCA
HOGENOMiHOG000006004
OMAiNRYWNQF
OrthoDBiEOG0936048P

Enzyme and pathway databases

UniPathwayi
UPA00143

Gene expression databases

ExpressionAtlasiA2XW69 differential

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR013956 E3_ubiquit_lig_Bre1
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR23163 PTHR23163, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBRE1A_ORYSI
AccessioniPrimary (citable) accession number: A2XW69
Secondary accession number(s): B8ASX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 70 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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