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UniProtKB - A2XAZ3 (ADHX_ORYSI)
Protein
Alcohol dehydrogenase class-3
Gene
ADHIII
Organism
Oryza sativa subsp. indica (Rice)
Status
Functioni
Catalytic activityi
Cofactori
Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 49 | Zinc 1; catalyticBy similarity | 1 | |
Binding sitei | 50 | NADBy similarity | 1 | |
Binding sitei | 51 | SubstrateBy similarity | 1 | |
Metal bindingi | 71 | Zinc 1; catalyticBy similarity | 1 | |
Binding sitei | 71 | SubstrateBy similarity | 1 | |
Metal bindingi | 72 | Zinc 1By similarity | 1 | |
Metal bindingi | 101 | Zinc 2By similarity | 1 | |
Metal bindingi | 104 | Zinc 2By similarity | 1 | |
Metal bindingi | 107 | Zinc 2By similarity | 1 | |
Metal bindingi | 115 | Zinc 2By similarity | 1 | |
Metal bindingi | 179 | Zinc 1; catalyticBy similarity | 1 | |
Binding sitei | 228 | NADBy similarity | 1 | |
Binding sitei | 233 | NADBy similarity | 1 | |
Binding sitei | 274 | NAD; via carbonyl oxygenBy similarity | 1 | |
Binding sitei | 374 | NADBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 204 – 209 | NADBy similarity | 6 | |
Nucleotide bindingi | 297 – 299 | NADBy similarity | 3 | |
Nucleotide bindingi | 322 – 324 | NADBy similarity | 3 |
GO - Molecular functioni
- alcohol dehydrogenase (NAD+) activity Source: UniProtKB-EC
- S-(hydroxymethyl)glutathione dehydrogenase NAD activity Source: UniProtKB-EC
- S-(hydroxymethyl)glutathione dehydrogenase NADP activity Source: UniProtKB-EC
- zinc ion binding Source: InterPro
GO - Biological processi
- ethanol oxidation Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Metal-binding, NAD, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ADHIII ORF Names:OsI_009236 |
Organismi | Oryza sativa subsp. indica (Rice) |
Taxonomic identifieri | 39946 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000291457 | 1 – 381 | Alcohol dehydrogenase class-3Add BLAST | 381 |
Proteomic databases
PRIDEi | A2XAZ3 |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 39946.A2XAZ3 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_026673_14_0_1 |
OMAi | IHHYMGT |
Family and domain databases
CDDi | cd08300, alcohol_DH_class_III, 1 hit |
InterProi | View protein in InterPro IPR013149, ADH-like_C IPR014183, ADH_3 IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SUPFAMi | SSF50129, SSF50129, 2 hits SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR02818, adh_III_F_hyde, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
i Sequence
Sequence statusi: Complete.
A2XAZ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASSTQGQVI TCKAAVAWEA NKPMTIEDVQ VAPPQAGEVR VKILFTALCH
60 70 80 90 100
TDHYTWSGKD PEGLFPCILG HEAAGIVESV GEGVTEVQPG DHVIPCYQAE
110 120 130 140 150
CRECKFCKSG KTNLCGKVRA ATGVGVMMND RKSRFSINGK PIYHFMGTST
160 170 180 190 200
FSQYTVVHDV SVAKINPQAP LDKVCLLGCG VSTGLGAVWN TAKVEAGSIV
210 220 230 240 250
AIFGLGTVGL AVAEGAKSAG ASRIIGIDID SKKFDVAKNF GVTEFVNPKD
260 270 280 290 300
HDKPIQQVIV DLTDGGVDYS FECIGNVSVM RSALECCHKG WGTSVIVGVA
310 320 330 340 350
ASGQEISTRP FQLVTGRVWK GTAFGGFKSR SQVPWLVEKY LNKEIKVDEY
360 370 380
VTHSMNLTDI NKAFDLLHEG GCLRCVLATD K
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 48 | L → F in AAB19117 (PubMed:9215914).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77637 Genomic DNA Translation: AAB19117.1 CM000127 Genomic DNA Translation: EAY88003.1 |
PIRi | T04164 |
Genome annotation databases
EnsemblPlantsi | BGIOSGA009283-TA; BGIOSGA009283-PA; BGIOSGA009283 |
Gramenei | BGIOSGA009283-TA; BGIOSGA009283-PA; BGIOSGA009283 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77637 Genomic DNA Translation: AAB19117.1 CM000127 Genomic DNA Translation: EAY88003.1 |
PIRi | T04164 |
3D structure databases
AlphaFoldDBi | A2XAZ3 |
SMRi | A2XAZ3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 39946.A2XAZ3 |
Proteomic databases
PRIDEi | A2XAZ3 |
Genome annotation databases
EnsemblPlantsi | BGIOSGA009283-TA; BGIOSGA009283-PA; BGIOSGA009283 |
Gramenei | BGIOSGA009283-TA; BGIOSGA009283-PA; BGIOSGA009283 |
Phylogenomic databases
HOGENOMi | CLU_026673_14_0_1 |
OMAi | IHHYMGT |
Family and domain databases
CDDi | cd08300, alcohol_DH_class_III, 1 hit |
InterProi | View protein in InterPro IPR013149, ADH-like_C IPR014183, ADH_3 IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SUPFAMi | SSF50129, SSF50129, 2 hits SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR02818, adh_III_F_hyde, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ADHX_ORYSI | |
Accessioni | A2XAZ3Primary (citable) accession number: A2XAZ3 Secondary accession number(s): P93436, Q6K6C1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 12, 2007 |
Last sequence update: | March 20, 2007 | |
Last modified: | May 25, 2022 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families