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Protein

Mitogen-activated protein kinase 13

Gene

MPK13

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Activity regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42ATPPROSITE-ProRule annotation1
Active sitei139Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 27ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-OSA-4086398 Ca2+ pathway
R-OSA-5687128 MAPK6/MAPK4 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 13 (EC:2.7.11.24)
Short name:
MAP kinase 13
Alternative name(s):
Benzothiadiazole-induced MAP kinase 2
MAP kinase 2
OsBIMK2
OsBWMK2
OsMAPK2
OsMPK17-2
Wound- and blast-induced MAPK 2
Gene namesi
Name:MPK13
Synonyms:BIMK2, BWMK2, MAPK2, MPK17-2
ORF Names:OsI_005614
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000007015 Componenti: Chromosome 2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003008711 – 506Mitogen-activated protein kinase 13Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175PhosphothreonineBy similarity1
Modified residuei177PhosphotyrosineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA2X0M1

PTM databases

iPTMnetiA2X0M1

Expressioni

Inductioni

By salicylic acid (SA), ethylene and infection with rice blast fungus (M.grisea).

Gene expression databases

ExpressionAtlasiA2X0M1 differential

Interactioni

Protein-protein interaction databases

STRINGi39946.BGIOSGA007171-PA

Structurei

3D structure databases

ProteinModelPortaliA2X0M1
SMRiA2X0M1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 304Protein kinasePROSITE-ProRule annotationAdd BLAST292

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi175 – 177TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
OrthoDBiEOG093605CF

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

A2X0M1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFFTEYGEA SQYQIQEVVG KGSYGVVAAA VDTHTGERVA IKKINDVFEH
60 70 80 90 100
VSDAIRILRE IKVLRLLRHP DIVVIKHIML PPTRREFRDI YVVFELMESD
110 120 130 140 150
LHQVIEANHD LSPEHHRFFL YQLLCALKYI HSANVFHRDL KPKNILANSD
160 170 180 190 200
CKLKICDFGL ARVAFNDSPS TIFWTDYVAT RWYRAPELCG SFFSKYTPAI
210 220 230 240 250
DIWSIGCIFA EILTGRPLFP GRNVVHQLDL ITDLLGTPSS ETLSRIRNEN
260 270 280 290 300
ARGYLTGMQR KHPIPFSHKF HNADPLALRL LERLLAFDPK DRPTAEEALA
310 320 330 340 350
DPYFRGISKL SREPSRLPVS KFEFEFERRK LTKDDVREMI YREILEYHPQ
360 370 380 390 400
MLQEYIRGGE QISFLYPSGV DRFKRQFAHL EENYSRGERS TPLRRQHASL
410 420 430 440 450
PRERVCSSVD SNNQDSDNEE RRAISSIART MISPPRSQEK GKNRASAYPN
460 470 480 490 500
GIINLNSNPK IYLKSASISA STCIIRGNKG PKENGISEDM EEVVYELSDN

VTRMLS
Length:506
Mass (Da):58,281
Last modified:September 11, 2007 - v2
Checksum:i7EBCBA768079F972
GO

Sequence cautioni

The sequence EAY84381 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY524973 mRNA Translation: AAS18417.1
AY524974 Genomic DNA Translation: AAS18418.1
DQ826423 mRNA Translation: ABH01190.2
CM000127 Genomic DNA Translation: EAY84381.1 Sequence problems.

Similar proteinsi

Entry informationi

Entry nameiMPK13_ORYSI
AccessioniPrimary (citable) accession number: A2X0M1
Secondary accession number(s): Q0PIU6
, Q6QUV9, Q6Z831, Q9SE22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: September 12, 2018
This is version 62 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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