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Entry version 108 (08 May 2019)
Sequence version 2 (28 Mar 2018)
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Protein

SCO-spondin

Gene

SSPO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SCO-spondinCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SSPOImported
Synonyms:KIAA2036
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:21998 SSPO

Online Mendelian Inheritance in Man (OMIM)

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MIMi
617356 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A2VEC9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23145

Open Targets

More...
OpenTargetsi
ENSG00000197558

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA142670865

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SSPO

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500022375718 – 5150SCO-spondinAdd BLAST5133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi261N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi820N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi912N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi945N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi987N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1353N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1377 ↔ 1390PROSITE-ProRule annotation
Disulfide bondi1384 ↔ 1403PROSITE-ProRule annotation
Disulfide bondi1397 ↔ 1412PROSITE-ProRule annotation
Disulfide bondi1417 ↔ 1429PROSITE-ProRule annotation
Disulfide bondi1424 ↔ 1442PROSITE-ProRule annotation
Disulfide bondi1436 ↔ 1453PROSITE-ProRule annotation
Disulfide bondi1453 ↔ 1465PROSITE-ProRule annotation
Disulfide bondi1460 ↔ 1478PROSITE-ProRule annotation
Disulfide bondi1472 ↔ 1487PROSITE-ProRule annotation
Disulfide bondi1493 ↔ 1505PROSITE-ProRule annotation
Disulfide bondi1500 ↔ 1518PROSITE-ProRule annotation
Disulfide bondi1512 ↔ 1529PROSITE-ProRule annotation
Disulfide bondi1566 ↔ 1578PROSITE-ProRule annotation
Disulfide bondi1573 ↔ 1591PROSITE-ProRule annotation
Disulfide bondi1585 ↔ 1600PROSITE-ProRule annotation
Disulfide bondi1604 ↔ 1617PROSITE-ProRule annotation
Disulfide bondi1611 ↔ 1630PROSITE-ProRule annotation
Disulfide bondi1624 ↔ 1641PROSITE-ProRule annotation
Glycosylationi1651N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1657 ↔ 1667PROSITE-ProRule annotation
Disulfide bondi1662 ↔ 1680PROSITE-ProRule annotation
Glycosylationi1664N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1674 ↔ 1695PROSITE-ProRule annotation
Disulfide bondi1707 ↔ 1743PROSITE-ProRule annotation
Disulfide bondi1711 ↔ 1748PROSITE-ProRule annotation
Disulfide bondi1722 ↔ 1733PROSITE-ProRule annotation
Disulfide bondi1763 ↔ 1803PROSITE-ProRule annotation
Disulfide bondi1767 ↔ 1808PROSITE-ProRule annotation
Disulfide bondi1777 ↔ 1787PROSITE-ProRule annotation
Glycosylationi1810N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1911 ↔ 1950PROSITE-ProRule annotation
Disulfide bondi1922 ↔ 1926PROSITE-ProRule annotation
Disulfide bondi1960 ↔ 1965PROSITE-ProRule annotation
Glycosylationi1994N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2031N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2066 ↔ 2225PROSITE-ProRule annotation
Glycosylationi2134N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2235 ↔ 2247PROSITE-ProRule annotation
Disulfide bondi2242 ↔ 2260PROSITE-ProRule annotation
Disulfide bondi2254 ↔ 2269PROSITE-ProRule annotation
Disulfide bondi2392 ↔ 2404PROSITE-ProRule annotation
Disulfide bondi2399 ↔ 2417PROSITE-ProRule annotation
Disulfide bondi2411 ↔ 2426PROSITE-ProRule annotation
Disulfide bondi2465 ↔ 2477PROSITE-ProRule annotation
Disulfide bondi2472 ↔ 2490PROSITE-ProRule annotation
Disulfide bondi2484 ↔ 2499PROSITE-ProRule annotation
Disulfide bondi2502 ↔ 2538PROSITE-ProRule annotation
Disulfide bondi2513 ↔ 2517PROSITE-ProRule annotation
Disulfide bondi2548 ↔ 2553PROSITE-ProRule annotation
Disulfide bondi2568 ↔ 2605PROSITE-ProRule annotation
Disulfide bondi2572 ↔ 2610PROSITE-ProRule annotation
Disulfide bondi2583 ↔ 2595PROSITE-ProRule annotation
Glycosylationi2646N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2695N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2717 ↔ 2755PROSITE-ProRule annotation
Disulfide bondi2728 ↔ 2732PROSITE-ProRule annotation
Disulfide bondi2765 ↔ 2769PROSITE-ProRule annotation
Disulfide bondi2785 ↔ 2823PROSITE-ProRule annotation
Disulfide bondi2789 ↔ 2828PROSITE-ProRule annotation
Disulfide bondi2805 ↔ 2813PROSITE-ProRule annotation
Disulfide bondi2843 ↔ 2878PROSITE-ProRule annotation
Disulfide bondi2847 ↔ 2883PROSITE-ProRule annotation
Disulfide bondi2858 ↔ 2868PROSITE-ProRule annotation
Glycosylationi2937N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2968N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2987 ↔ 3025PROSITE-ProRule annotation
Disulfide bondi2998 ↔ 3002PROSITE-ProRule annotation
Disulfide bondi3035 ↔ 3040PROSITE-ProRule annotation
Glycosylationi3063N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3174N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3196 ↔ 3245PROSITE-ProRule annotation
Disulfide bondi3200 ↔ 3250PROSITE-ProRule annotation
Disulfide bondi3211 ↔ 3235PROSITE-ProRule annotation
Disulfide bondi3265 ↔ 3302PROSITE-ProRule annotation
Disulfide bondi3269 ↔ 3307PROSITE-ProRule annotation
Disulfide bondi3280 ↔ 3292PROSITE-ProRule annotation
Glycosylationi3311N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3400N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3421 ↔ 3464PROSITE-ProRule annotation
Disulfide bondi3425 ↔ 3470PROSITE-ProRule annotation
Disulfide bondi3436 ↔ 3448PROSITE-ProRule annotation
Disulfide bondi3485 ↔ 3520PROSITE-ProRule annotation
Disulfide bondi3488 ↔ 3527PROSITE-ProRule annotation
Disulfide bondi3498 ↔ 3510PROSITE-ProRule annotation
Glycosylationi3513N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3523N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3600N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3627N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3658 ↔ 3688PROSITE-ProRule annotation
Disulfide bondi3662 ↔ 3693PROSITE-ProRule annotation
Disulfide bondi3673 ↔ 3678PROSITE-ProRule annotation
Glycosylationi3793N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3824 ↔ 3862PROSITE-ProRule annotation
Disulfide bondi3828 ↔ 3867PROSITE-ProRule annotation
Disulfide bondi3840 ↔ 3852PROSITE-ProRule annotation
Glycosylationi3916N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3948N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3949 ↔ 3985PROSITE-ProRule annotation
Disulfide bondi3960 ↔ 3964PROSITE-ProRule annotation
Disulfide bondi3998 ↔ 4003PROSITE-ProRule annotation
Disulfide bondi4018 ↔ 4055PROSITE-ProRule annotation
Disulfide bondi4022 ↔ 4060PROSITE-ProRule annotation
Disulfide bondi4033 ↔ 4045PROSITE-ProRule annotation
Glycosylationi4141N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4162 ↔ 4198PROSITE-ProRule annotation
Disulfide bondi4173 ↔ 4177PROSITE-ProRule annotation
Disulfide bondi4208 ↔ 4213PROSITE-ProRule annotation
Glycosylationi4348N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4368 ↔ 4405PROSITE-ProRule annotation
Disulfide bondi4379 ↔ 4381PROSITE-ProRule annotation
Disulfide bondi4415 ↔ 4420PROSITE-ProRule annotation
Glycosylationi4419N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4734N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4751N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4756N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4778 ↔ 4813PROSITE-ProRule annotation
Disulfide bondi4782 ↔ 4818PROSITE-ProRule annotation
Disulfide bondi4793 ↔ 4802PROSITE-ProRule annotation
Glycosylationi4866N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4906N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4951N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4958N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi5044 ↔ 5104PROSITE-ProRule annotation
Glycosylationi5064N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi5070 ↔ 5121PROSITE-ProRule annotation
Disulfide bondi5080 ↔ 5137PROSITE-ProRule annotation
Disulfide bondi5084 ↔ 5139PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A2VEC9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
545
546 [A2VEC9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2VEC9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2VEC9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197558 Expressed in 106 organ(s), highest expression level in right hemisphere of cerebellum

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116762, 5 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2VEC9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 102EMIAdd BLAST85
Domaini194 – 398VWFD 1PROSITE-ProRule annotationAdd BLAST205
Domaini470 – 525TIL 1Sequence analysisAdd BLAST56
Domaini564 – 774VWFD 2PROSITE-ProRule annotationAdd BLAST211
Domaini828 – 881TIL 2Sequence analysisAdd BLAST54
Domaini881 – 940VWFC 1PROSITE-ProRule annotationAdd BLAST60
Domaini924 – 975TIL 3Sequence analysisAdd BLAST52
Domaini1014 – 1220VWFD 3PROSITE-ProRule annotationAdd BLAST207
Domaini1276 – 1332TIL 4Sequence analysisAdd BLAST57
Domaini1376 – 1413LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST38
Domaini1416 – 1451LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST36
Domaini1452 – 1488LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST37
Domaini1492 – 1530LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST39
Domaini1565 – 1601LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST37
Domaini1603 – 1642LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST40
Domaini1656 – 1694LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST39
Domaini1695 – 1749TSP type-1 1PROSITE-ProRule annotationAdd BLAST55
Domaini1751 – 1809TSP type-1 2PROSITE-ProRule annotationAdd BLAST59
Domaini1825 – 1864EGF-like 1Add BLAST40
Domaini1865 – 1902EGF-like 2Add BLAST38
Domaini1910 – 1966TSP type-1 3PROSITE-ProRule annotationAdd BLAST57
Domaini1966 – 2026VWFC 2PROSITE-ProRule annotationAdd BLAST61
Domaini2066 – 2225F5/8 type CPROSITE-ProRule annotationAdd BLAST160
Domaini2234 – 2270LDL-receptor class A 8PROSITE-ProRule annotationAdd BLAST37
Domaini2391 – 2427LDL-receptor class A 9PROSITE-ProRule annotationAdd BLAST37
Domaini2464 – 2500LDL-receptor class A 10PROSITE-ProRule annotationAdd BLAST37
Domaini2501 – 2554TSP type-1 4PROSITE-ProRule annotationAdd BLAST54
Domaini2556 – 2611TSP type-1 5PROSITE-ProRule annotationAdd BLAST56
Domaini2633 – 2676TIL 5Sequence analysisAdd BLAST44
Domaini2716 – 2770TSP type-1 6PROSITE-ProRule annotationAdd BLAST55
Domaini2773 – 2829TSP type-1 7PROSITE-ProRule annotationAdd BLAST57
Domaini2831 – 2884TSP type-1 8PROSITE-ProRule annotationAdd BLAST54
Domaini2986 – 3041TSP type-1 9PROSITE-ProRule annotationAdd BLAST56
Domaini3042 – 3084TSP type-1 10PROSITE-ProRule annotationAdd BLAST43
Domaini3091 – 3143TIL 6Sequence analysisAdd BLAST53
Domaini3184 – 3251TSP type-1 11PROSITE-ProRule annotationAdd BLAST68
Domaini3253 – 3308TSP type-1 12PROSITE-ProRule annotationAdd BLAST56
Domaini3316 – 3366TIL 7Sequence analysisAdd BLAST51
Domaini3409 – 3471TSP type-1 13PROSITE-ProRule annotationAdd BLAST63
Domaini3473 – 3528TSP type-1 14PROSITE-ProRule annotationAdd BLAST56
Domaini3530 – 3586TIL 8Sequence analysisAdd BLAST57
Domaini3646 – 3694TSP type-1 15PROSITE-ProRule annotationAdd BLAST49
Domaini3812 – 3868TSP type-1 16PROSITE-ProRule annotationAdd BLAST57
Domaini3882 – 3934TSP type-1 17PROSITE-ProRule annotationAdd BLAST53
Domaini3948 – 4004TSP type-1 18PROSITE-ProRule annotationAdd BLAST57
Domaini4006 – 4061TSP type-1 19PROSITE-ProRule annotationAdd BLAST56
Domaini4064 – 4119TIL 9Sequence analysisAdd BLAST56
Domaini4161 – 4214TSP type-1 20PROSITE-ProRule annotationAdd BLAST54
Domaini4255 – 4307TSP type-1 21PROSITE-ProRule annotationAdd BLAST53
Domaini4309 – 4365TSP type-1 22PROSITE-ProRule annotationAdd BLAST57
Domaini4367 – 4421TSP type-1 23PROSITE-ProRule annotationAdd BLAST55
Domaini4425 – 4480TIL 10Sequence analysisAdd BLAST56
Domaini4617 – 4667TSP type-1 24PROSITE-ProRule annotationAdd BLAST51
Domaini4678 – 4726TIL 11Sequence analysisAdd BLAST49
Domaini4766 – 4819TSP type-1 25PROSITE-ProRule annotationAdd BLAST54
Domaini4821 – 4875TIL 12Sequence analysisAdd BLAST55
Domaini4987 – 5045VWFC 3PROSITE-ProRule annotationAdd BLAST59
Domaini5044 – 5143CTCKPROSITE-ProRule annotationAdd BLAST100

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thrombospondin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155829

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154433

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A2VEC9

Identification of Orthologs from Complete Genome Data

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OMAi
MQTKNEL

Database of Orthologous Groups

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OrthoDBi
12226at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
A2VEC9

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00057 FA58C, 1 hit
cd00112 LDLa, 9 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 21 hits
2.60.120.260, 1 hit
4.10.400.10, 9 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006207 Cys_knot_C
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR036201 Pacifastin_dom_sf
IPR030119 SCO-spondin
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D

The PANTHER Classification System

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PANTHERi
PTHR11339:SF358 PTHR11339:SF358, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF08742 C8, 3 hits
PF00754 F5_F8_type_C, 1 hit
PF00057 Ldl_recept_a, 8 hits
PF01826 TIL, 12 hits
PF00090 TSP_1, 21 hits
PF00094 VWD, 3 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00261 LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00832 C8, 3 hits
SM00231 FA58C, 1 hit
SM00192 LDLa, 10 hits
SM00209 TSP1, 25 hits
SM00214 VWC, 6 hits
SM00215 VWC_out, 9 hits
SM00216 VWD, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49785 SSF49785, 1 hit
SSF57283 SSF57283, 1 hit
SSF57424 SSF57424, 10 hits
SSF57567 SSF57567, 14 hits
SSF82895 SSF82895, 23 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS01225 CTCK_2, 1 hit
PS00022 EGF_1, 1 hit
PS50022 FA58C_3, 1 hit
PS01209 LDLRA_1, 8 hits
PS50068 LDLRA_2, 10 hits
PS50092 TSP1, 25 hits
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 2 hits
PS51233 VWFD, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A2VEC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLPALLFGM AWALADGRWC EWTETIRVEE EVAPRQEDLV PCASLDHYSR
60 70 80 90 100
LGWRLDLPWS GRSGLTRSPA PGLCPIYKPP ETRPAKWNRT VRTCCPGWGG
110 120 130 140 150
AHCTEALAKA SPEGHCFAMW QCQLQAGSAN ASAGSLEECC ARPWGQSWWD
160 170 180 190 200
GSSQACRSCS SRHLPGSASS PALLQPLAGA VGQLWSQHQR PSATCASWSG
210 220 230 240 250
FHYRTFDGRH YHFLGRCTYL LAGAADSTWA VHLTPGDRCP QPGHCQRVTM
260 270 280 290 300
GPEEVLIQAG NVSVKGQLVP EGQSWLLHGL SLQWLGDWLV LSGGLGVVVR
310 320 330 340 350
LDRTGSISIS VDHELWGQTQ GLCGLYNGWP EDDFMEPGGG LAMLAATFGN
360 370 380 390 400
SWRLPGSESG CLDAVEVAQG CDSPLGLIDA DVEPGHLRAE AQDVCHQLLE
410 420 430 440 450
GPFGQCHAQV SPAEYHEACL FAYCAGAMAG SGQEGRQQAV CATFASYVQA
460 470 480 490 500
CARRHIHIRW RKPGFCERLC PGGQLYSDCV SLCPPSCEAV GQGEEESCRE
510 520 530 540 550
ECVSGCECPR GLFWNGTLCV PAAHCPCYYC RQRYVPGDTV RQLCNPCVCR
560 570 580 590 600
DGRWHCAQAL CPAECAVGGD GHYLTFDGRS YSFWGGQGCR YSLVQDYVKG
610 620 630 640 650
QLLILLEHGA CDAGSCLHAI SVSLEDTHIQ LRDSGAVLVN GQDVGLPWIG
660 670 680 690 700
AEGLSVRRAS SAFLLLRWPG AQVLWGLSDP VAYITLDPRH AHQVQGLCGT
710 720 730 740 750
FTQNQQDDFL TPAGDVETSI AAFASKFQVA GKGRCPSEDS ALLSPCTTHS
760 770 780 790 800
QRHAFAEAAC AILHSSVFQE CHRLVDKEPF YLRCLAAVCG CDPGSDCLCP
810 820 830 840 850
VLSAYARRCA QEGASPPWRN QTLCPVMCPG GQEYRECAPA CGQHCGKPED
860 870 880 890 900
CGELGSCVAG CNCPLGLLWD PEGQCVPPSL CPCQLGARRY APGSATMKEC
910 920 930 940 950
NRCICQERGL WNCTARHCPS QAFCPRELVY APGACLLTCD SPSANHSCPA
960 970 980 990 1000
GSTDGCVCPP GTVLLDERCV PPDLCPCRHS GQWYLPNATI QEDCNVCVCR
1010 1020 1030 1040 1050
GRQWHCTGQR RSGRCQASGA PHYVTFDGLA FTYPGACEYL LVREASGLFT
1060 1070 1080 1090 1100
VSAQNLPCGA SGLTCTKALA VRLEGTVVHM LRGRAVTVNG VSVTPPKVYT
1110 1120 1130 1140 1150
GPGLSLRRAG LFLLLSTHLG LTLLWDGGTR VLVQLSPQFR GRVAGLCGDF
1160 1170 1180 1190 1200
DGDASNDLRS RQGVLEPTAE LAAHSWRLSP LCPEPGDLPH PCTMNTHRAG
1210 1220 1230 1240 1250
WARARCGALL QPLFTLCHAE VPPQQHYEWC LYDACGCDSG GDCECLCSAI
1260 1270 1280 1290 1300
ATYADECARH GHHVRWRSQE LCSLQCEGGQ VYEACGPTCP PTCHEQHPEP
1310 1320 1330 1340 1350
GWHCQVVACV EGCFCPEGTL LHGGACLEPA SCPCEWGRNS FPPGSVLQKD
1360 1370 1380 1390 1400
CGNCTCQEGQ WHCGGDGGHC EELVPACAEG EALCQENGHC VPHGWLCDNQ
1410 1420 1430 1440 1450
DDCGDGSDEE GCAAPGCGEG QMTCSSGHCL PLALLCDRQD DCGDGTDEPS
1460 1470 1480 1490 1500
YPCPQGLLAC ADGRCLPPAL LCDGHPDCLD AADEESCLGQ VTCVPGEVSC
1510 1520 1530 1540 1550
VDGTCLGAIQ LCDGVWDCPD GADEGPGHCP LPSLPTPPAS TLPGPSPGSL
1560 1570 1580 1590 1600
DTASSPLASA SPAPPCGPFE FRCGSGECTP RGWRCDQEED CADGSDERGC
1610 1620 1630 1640 1650
GGPCAPHHAP CARGPHCVSP EQLCDGVRQC PDGSDEGPDA CGGLPALGGP
1660 1670 1680 1690 1700
NRTGLPCPEY TCPNGTCIGF QLVCDGQPDC GRPGQVGPSP EEQGCGAWGP
1710 1720 1730 1740 1750
WSPWGPCSRT CGPWGQGRSR RCSPLGLLVL QNCPGPEHQS QACFTAACPV
1760 1770 1780 1790 1800
DGEWSTWSPW SVCSEPCRGT MTRQRQCHSP QNGGRTCAAL PGGLHSTRQT
1810 1820 1830 1840 1850
KPCPQDGCPN ATCSGELMFQ PCAPCPLTCD DISGQVTCPP DWPCGSPGCW
1860 1870 1880 1890 1900
CPEGQVLGSE GWCVWPRQCP CLVDGARYWP GQRIKADCQL CICQDGRPRR
1910 1920 1930 1940 1950
CRLNPDCAVD CGWSSWSPWA KCLGPCGSQS IQWSFRSSNN PRPSGRGRQC
1960 1970 1980 1990 2000
RGIHRKARRC QTEPCEGCEH QGQVHRVGER WHGGPCRVCQ CLHNLTAHCS
2010 2020 2030 2040 2050
PYCPLGSCPQ GWVLVEGTGE SCCHCALPGE NQTVQPMATP AAAPAPSPQI
2060 2070 2080 2090 2100
RFPLATYILP PSGDPCYSPL GLAGLAEGSL HASSQQLEHP TQAALLGAPT
2110 2120 2130 2140 2150
QGPSPQGWHA GGDAYAKWHT RPHYLQLDLL QPRNLTGILV PETGSSNAYA
2160 2170 2180 2190 2200
SSFSLQFSSN GLHWHDYRDL LPGILPLPKL FPRNWDDLDP AVWTFGRMVQ
2210 2220 2230 2240 2250
ARFVRVWPHD VHHSDVPLQV ELLGCEPGSP PAPLCPGVGL RCASGECVLR
2260 2270 2280 2290 2300
GGPCDGVLDC EDGSDEEGCV LLPEGTGRFH STAKTLALSS AQPGQLLHWP
2310 2320 2330 2340 2350
REGLAETEHW PPGQESPTSP TETRPVSPGP ASGVPHHGES VQMVTTTPIP
2360 2370 2380 2390 2400
QMEARTLPPG MAAVTVVPPH PVTPATPAGQ SVAPGPFPPV QCGPGQTPCE
2410 2420 2430 2440 2450
VLGCVEQAQV CDGREDCLDG SDERHCARNL LMWLPSLPAL WAASTVPFMM
2460 2470 2480 2490 2500
PTMALPGLPA SRALCSPSQL SCGSGECLSA ERRCDLRPDC QDGSDEDGCV
2510 2520 2530 2540 2550
DCVLAPWSVW SSCSRSCGLG LTFQRQELLR PPLPGGSCPR DRFRSQSCFV
2560 2570 2580 2590 2600
QACPVAGAWA MWEAWGPCSV SCGGGHQSRQ RSCVDPPPKN GGAPCPGASQ
2610 2620 2630 2640 2650
ERAPCGLQPC SGGTDCELGR VYVSADLCQK GLVPPCPPSC LDPKANRSCS
2660 2670 2680 2690 2700
GHCVEGCRCP PGLLLHDTRC LPLSECPCLV GEELKWPGVS FLLGNCSQCV
2710 2720 2730 2740 2750
CEKGELLCQP GGCPLPCGWS AWSSWAPCDR SCGSGVRARF RSPSNPPAAW
2760 2770 2780 2790 2800
GGAPCEGDRQ ELQGCHTVCG TEVFGWTPWT SWSSCSQSCL APGGGPGWRS
2810 2820 2830 2840 2850
RSRLCPSPGD SSCPGDATQE EPCSPPVCPV PSIWGLWAPW STCSAPCDGG
2860 2870 2880 2890 2900
IQTRGRSCSS LAPGDTTCPG PHSQTRDCNT QPCTAQCPEN MLFRSAEQCH
2910 2920 2930 2940 2950
QEGGPCPRLC LTQGPGIECT GFCAPGCTCP PGLFLHNASC LPRSQCPCQL
2960 2970 2980 2990 3000
HGQLYASGAM ARLDSCNNCT CVSGKMACTS ERCPVACGWS PWTLWSLCSC
3010 3020 3030 3040 3050
SCNVGIRRRF RAGTAPPAAF GGAECQGPTM EAEFCSLRPC PGPGGEWGPW
3060 3070 3080 3090 3100
SPCSVPCGGG YRNRTRGSSR SLMEFSTCGL QPCAGPVPGM CPRDKQWLDC
3110 3120 3130 3140 3150
AQGPASCAEL SAPRGTNQTC HPGCHCPSGM LLLNNVCVPT QDCPCAHEGH
3160 3170 3180 3190 3200
LYPPGSTVVR PCENCSCVSG LIANCSSWPC AEGEPTWSPW TPWSQCSASC
3210 3220 3230 3240 3250
GPARCHRHRF CARSPSAVPS TVAPLPLPAT PTPLCSGPEA EEEPCLLQGC
3260 3270 3280 3290 3300
DRAGGWGPWG PWSHCSRSCG GGLRSRTRAC DQPPPQGLGD YCEGPRAQGE
3310 3320 3330 3340 3350
VCQALPCPVT NCTAIEGAEY SPCGPPCPRS CDDLVHCVWR CQPGCYCPPG
3360 3370 3380 3390 3400
QVLSSNGAIC VQPGHCSCLD LLTGQRHHPG ARLARPDGCN HCTCLEGRLN
3410 3420 3430 3440 3450
CTDLPCPVPG GWCPWSEWTM CSQPCRGQTR SRSRACACPT PQHGGAPCTG
3460 3470 3480 3490 3500
EAGEAGAQHQ REACPSYATC PVDGAWGPWG PWSPCDMCLG QSHRSRACSR
3510 3520 3530 3540 3550
PPTPEGGRPC PGNHTQSRPC QENSTQCTDC GGGQSLHPCG QPCPRSCQDL
3560 3570 3580 3590 3600
SPGSVCQPGS VGCQPTCGCP LGQLSQDGLC VPPAHCRCQY QPGAMGIPEN
3610 3620 3630 3640 3650
QSRSAGSRFS SWESLEPGEV VTGPCDNCTC VAGILQCQEV PDCPDPGVWS
3660 3670 3680 3690 3700
SWGPWEDCSV SCGGGEQLRS RRCARPPCPG PARQSRTCST QVCREAGCPA
3710 3720 3730 3740 3750
GRLYRECQPG EGCPFSCAHV TQQVGCFSEG CEEGCHCPEG TFQHRLACVQ
3760 3770 3780 3790 3800
ECPCVLTAWL LQELGATIGD PGQPLGPGDE LDSGQTLRTS CGNCSCAHGK
3810 3820 3830 3840 3850
LSCSLDDCFE ADGGFGPWSP WGPCSRSCGG LGTRTRSRQC VLTMPTLSGQ
3860 3870 3880 3890 3900
GCRGPRQDLE YCPSPDCPGA EGSTVEPVTG LPGGWGPWSS WSPCSRSCTD
3910 3920 3930 3940 3950
PARPAWRSRT RLCLANCTMG DPLQERPCNL PSCTELPVCP GPGCGAGNCS
3960 3970 3980 3990 4000
WTSWAPWEPC SRSCGVGQQR RLRAYRPPGP GGHWCPNILT AYQERRFCNL
4010 4020 4030 4040 4050
RACPVPGGWS RWSPWSWCDR SCGGGQSLRS RSCSSPPSKN GGAPCAGERH
4060 4070 4080 4090 4100
QARLCNPMPC EAGCPAGMEV VTCANRCPRR CSDLQEGIVC QDDQVCQKGC
4110 4120 4130 4140 4150
RCPKGSLEQD GGCVPIGHCD CTDAQGHSWA PGSQHQDACN NCSCQAGQLS
4160 4170 4180 4190 4200
CTAQPCPPPT HCAWSHWSAW SPCSHSCGPR GQQSRFRSST SGSWAPECRE
4210 4220 4230 4240 4250
EQSQSQPCPQ PSCPPLCLQG TRSRTLGDSW LQGECQRCSC TPEGVICEDT
4260 4270 4280 4290 4300
ECAVPEAWTL WSSWSDCPVS CGGGNQVRTR ACRAAAPHHR SPPCLGPDTQ
4310 4320 4330 4340 4350
TRQQPCPGLL EACSWGPWGP CSRSCGPGLA SRSGSCPCLM AKADPTCNST
4360 4370 4380 4390 4400
FLHLDTQGCY SGPCPEECVW SSWSSWTRCS CRVLVQQRYR HQGPASRGAR
4410 4420 4430 4440 4450
AGAPCTRLDG HFRPCLISNC SEDSCTPPFE FHACGSPCAG LCATHLSHQL
4460 4470 4480 4490 4500
CQDLPPCQPG CYCPKGLLEQ AGGCIPPEEC NCWHTSAAGA GMTLAPGDRL
4510 4520 4530 4540 4550
QLGCKECECR RGELHCTSQG CQGLLPLSEW SEWSPCGPCL PPSALAPASR
4560 4570 4580 4590 4600
TALEEHWLRD PTGLSPTLAP LLASEQHRHR LCLDPATGRP WTGAPHLCTA
4610 4620 4630 4640 4650
PLSQQRLCPD PGACPDSCQW SLWGPWSPCQ VPCSGGFRLR WREAEALCGG
4660 4670 4680 4690 4700
GCREPWAQES CNGGPCPESC EAQDTVFTLD CANQCPHSCA DLWDRVQCLQ
4710 4720 4730 4740 4750
GPCRPGCRCP PGQLVQDGRC VPISSCRCGL PSANASWELA PAQAVQLDCQ
4760 4770 4780 4790 4800
NCTCVNESLV CPHQECPVLG PWSAWSSCSA PCGGGTMERH RTCEGGPGVA
4810 4820 4830 4840 4850
PCQAQDTEQR QECNLQPCPE CPPGQVLSAC ATSCPCLCWH LQPGAICVQE
4860 4870 4880 4890 4900
PCQPGCGCPG GQLLHNGTCV PPTACPCTQH SLPWGLTLTL EEQAQELPPG
4910 4920 4930 4940 4950
TVLTRNCTRC VCHGGAFSCS LVDCQVPPGE TWQQVAPGEL GLCEQTCLEM
4960 4970 4980 4990 5000
NATKTQSNCS SARASGCVCQ PGHFRSQAGP CVPEDHCECW HLGRPHLPGS
5010 5020 5030 5040 5050
EWQEACESCL CLSGRPVCTQ HCSPLTCAQG EEMVLEPGSC CPSCRREAPE
5060 5070 5080 5090 5100
EQSPSCQLLT ELRNFTKGTC YLDQVEVSYC SGYCPSSTHV MPEEPYLQSQ
5110 5120 5130 5140 5150
CDCCSYRLDP ESPVRILNLR CLGGHTEPVV LPVIHSCQCS SCQGGDFSKR
Length:5,150
Mass (Da):547,841
Last modified:March 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i14C531CC9A29423E
GO
Isoform 2 (identifier: A2VEC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1123: Missing.
     1124-1127: LWDG → MLPP
     1640-1640: A → ACVEAPAPPA...DCPQGEDELD
     1672-1672: L → LVRVGVGGGGGSAMLPPSTRALTPLPPQ
     2180-2315: LFPRNWDDLD...ETEHWPPGQE → VSPAQGRWGQ...RSGRNQSVLC
     2316-5147: Missing.

Note: No experimental confirmation available.
Show »
Length:1,317
Mass (Da):139,146
Checksum:i59DBAA7876F7F138
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC98376 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052660146Q → R. Corresponds to variant dbSNP:rs709061Ensembl.1
Natural variantiVAR_052661298V → M. Corresponds to variant dbSNP:rs17754559Ensembl.1
Natural variantiVAR_059863540V → M. Corresponds to variant dbSNP:rs855677Ensembl.1
Natural variantiVAR_0757091002R → W Found in patient with Joubert syndrome; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199648588Ensembl.1
Natural variantiVAR_0598641273S → P. Corresponds to variant dbSNP:rs709060Ensembl.1
Natural variantiVAR_0526621274L → P. Corresponds to variant dbSNP:rs709060Ensembl.1
Natural variantiVAR_0598651425S → G. Corresponds to variant dbSNP:rs855691Ensembl.1
Natural variantiVAR_0598661449P → Q. Corresponds to variant dbSNP:rs855692Ensembl.1
Natural variantiVAR_0598671454P → R. Corresponds to variant dbSNP:rs2074704Ensembl.1
Natural variantiVAR_0598681779S → P. Corresponds to variant dbSNP:rs893601Ensembl.1
Natural variantiVAR_0598691794L → P. Corresponds to variant dbSNP:rs1635802Ensembl.1
Natural variantiVAR_0598701883R → C. Corresponds to variant dbSNP:rs1076277Ensembl.1
Natural variantiVAR_0598712018T → M. Corresponds to variant dbSNP:rs4725314Ensembl.1
Natural variantiVAR_0619152453M → T. Corresponds to variant dbSNP:rs2074689Ensembl.1
Natural variantiVAR_0619162542R → Q. Corresponds to variant dbSNP:rs59522380Ensembl.1
Natural variantiVAR_0757102799R → C Found in patient with Joubert syndrome; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs181269877Ensembl.1
Natural variantiVAR_0598722892L → V. Corresponds to variant dbSNP:rs10260959Ensembl.1
Natural variantiVAR_0598733274R → W. Corresponds to variant dbSNP:rs740109Ensembl.1
Natural variantiVAR_0598743513N → S. Corresponds to variant dbSNP:rs10952230Ensembl.1
Natural variantiVAR_0598753894C → W. Corresponds to variant dbSNP:rs1557955Ensembl.1
Natural variantiVAR_0598763911R → C. Corresponds to variant dbSNP:rs745044Ensembl.1
Natural variantiVAR_0598774030S → I. Corresponds to variant dbSNP:rs1005603Ensembl.1
Natural variantiVAR_0619174109Q → H. Corresponds to variant dbSNP:rs12536873Ensembl.1
Natural variantiVAR_0598784166H → R. Corresponds to variant dbSNP:rs10233245Ensembl.1
Natural variantiVAR_0598794332R → C. Corresponds to variant dbSNP:rs1008336Ensembl.1
Natural variantiVAR_0598804790H → R. Corresponds to variant dbSNP:rs1004200Ensembl.1
Natural variantiVAR_0598814944E → K. Corresponds to variant dbSNP:rs12534509Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0352581 – 1123Missing in isoform 2. 1 PublicationAdd BLAST1123
Alternative sequenceiVSP_0352591124 – 1127LWDG → MLPP in isoform 2. 1 Publication4
Alternative sequenceiVSP_0352601640A → ACVEAPAPPAMRGPPGQAGG PTSSRAPSPPSPPEAQGEGR KGQERSRTHLTVPAGSTQLP LCPGLFPCGVAPGLCLTPEQ LCDGIPDCPQGEDELD in isoform 2. 1 Publication1
Alternative sequenceiVSP_0352611672L → LVRVGVGGGGGSAMLPPSTR ALTPLPPQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_0352622180 – 2315LFPRN…PPGQE → VSPAQGRWGQQPTMPFCGFH SLCPQGPSSVPEGHGLHSML VEYLVSSRDCALWSRGLGAT VTWMLETIQVAQTQGRYVKP ARERGWGDTKFTEGLREPRP THVFVESSLGTALPSGGLHP SRRQTARSGRNQSVLC in isoform 2. 1 PublicationAdd BLAST136
Alternative sequenceiVSP_0352632316 – 5147Missing in isoform 2. 1 PublicationAdd BLAST2832

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB111888 mRNA Translation: BAC98376.1 Different initiation.
AC004877 Genomic DNA No translation available.
KF459635 Genomic DNA No translation available.
KF495712 Genomic DNA No translation available.
KF459640 Genomic DNA No translation available.
BN000852 mRNA Translation: CAJ43920.1

NCBI Reference Sequences

More...
RefSeqi
NP_940857.2, NM_198455.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000378016; ENSP00000485256; ENSG00000197558 [A2VEC9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23145

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23145

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB111888 mRNA Translation: BAC98376.1 Different initiation.
AC004877 Genomic DNA No translation available.
KF459635 Genomic DNA No translation available.
KF495712 Genomic DNA No translation available.
KF459640 Genomic DNA No translation available.
BN000852 mRNA Translation: CAJ43920.1
RefSeqiNP_940857.2, NM_198455.2

3D structure databases

SMRiA2VEC9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116762, 5 interactors

PTM databases

iPTMnetiA2VEC9
PhosphoSitePlusiA2VEC9

Polymorphism and mutation databases

BioMutaiSSPO

Proteomic databases

PRIDEiA2VEC9
ProteomicsDBi545
546 [A2VEC9-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378016; ENSP00000485256; ENSG00000197558 [A2VEC9-1]
GeneIDi23145
KEGGihsa:23145

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23145
DisGeNETi23145

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SSPO

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0007194
HGNCiHGNC:21998 SSPO
MIMi617356 gene
neXtProtiNX_A2VEC9
OpenTargetsiENSG00000197558
PharmGKBiPA142670865

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000155829
HOGENOMiHOG000154433
InParanoidiA2VEC9
OMAiMQTKNEL
OrthoDBi12226at2759
PhylomeDBiA2VEC9

Enzyme and pathway databases

ReactomeiR-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SSPO human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SSPO

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23145

Protein Ontology

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PROi
PR:A2VEC9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000197558 Expressed in 106 organ(s), highest expression level in right hemisphere of cerebellum

Family and domain databases

CDDicd00057 FA58C, 1 hit
cd00112 LDLa, 9 hits
Gene3Di2.20.100.10, 21 hits
2.60.120.260, 1 hit
4.10.400.10, 9 hits
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR036201 Pacifastin_dom_sf
IPR030119 SCO-spondin
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
PANTHERiPTHR11339:SF358 PTHR11339:SF358, 1 hit
PfamiView protein in Pfam
PF08742 C8, 3 hits
PF00754 F5_F8_type_C, 1 hit
PF00057 Ldl_recept_a, 8 hits
PF01826 TIL, 12 hits
PF00090 TSP_1, 21 hits
PF00094 VWD, 3 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00832 C8, 3 hits
SM00231 FA58C, 1 hit
SM00192 LDLa, 10 hits
SM00209 TSP1, 25 hits
SM00214 VWC, 6 hits
SM00215 VWC_out, 9 hits
SM00216 VWD, 3 hits
SUPFAMiSSF49785 SSF49785, 1 hit
SSF57283 SSF57283, 1 hit
SSF57424 SSF57424, 10 hits
SSF57567 SSF57567, 14 hits
SSF82895 SSF82895, 23 hits
PROSITEiView protein in PROSITE
PS01225 CTCK_2, 1 hit
PS00022 EGF_1, 1 hit
PS50022 FA58C_3, 1 hit
PS01209 LDLRA_1, 8 hits
PS50068 LDLRA_2, 10 hits
PS50092 TSP1, 25 hits
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 2 hits
PS51233 VWFD, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSSPO_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2VEC9
Secondary accession number(s): A0A096LNW2, Q76B61
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 28, 2018
Last modified: May 8, 2019
This is version 108 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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