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Protein

Gremlin

Gene

GREM1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
GremlinUniRule annotation
Gene namesi
Name:GREM1Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Organism-specific databases

VGNCiVGNC:29633 GREM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24UniRule annotationAdd BLAST24
ChainiPRO_501398906725 – 184GremlinUniRule annotationAdd BLAST160

Expressioni

Gene expression databases

BgeeiENSBTAG00000046604 Expressed in 8 organ(s), highest expression level in adult mammalian kidney

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000056469

Structurei

3D structure databases

SMRiA2VE87
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 183CTCKInterPro annotationAdd BLAST88

Sequence similaritiesi

Belongs to the DAN family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410IG3Z Eukaryota
ENOG4111HEF LUCA
GeneTreeiENSGT00510000046909
HOGENOMiHOG000237358
HOVERGENiHBG051837
OMAiRVKECRC
OrthoDBiEOG091G0GL9
TreeFamiTF106445

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR004133 DAN
IPR017159 Gremlin-1/2
PfamiView protein in Pfam
PF03045 DAN, 1 hit
PIRSFiPIRSF037254 Gremlin_precursor, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit

Sequencei

Sequence statusi: Complete.

A2VE87-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRTAYTVGA LLLLLGTLLP AAEGKKKGSQ GAIPPPDKAQ HNDSEQTQSP
60 70 80 90 100
QQPGSRNRGR GQGRGTAMPG EEVLESSQEA LHVTERKYLK RDWCKTQPLK
110 120 130 140 150
QTIHEEGCNS RTIINRFCYG QCNSFYIPRH IRKEEGSFQS CSFCKPKKFT
160 170 180
TMMVTLNCPE LQPPTKKKRV TRVKQCRCIS IDLD
Length:184
Mass (Da):20,697
Last modified:March 20, 2007 - v1
Checksum:i4B588598DE12C47E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02028408 Genomic DNA No translation available.
BC133625 mRNA Translation: AAI33626.1
RefSeqiNP_001075919.1, NM_001082450.1
UniGeneiBt.104283

Genome annotation databases

EnsembliENSBTAT00000065609; ENSBTAP00000056469; ENSBTAG00000046604
GeneIDi539079
KEGGibta:539079

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02028408 Genomic DNA No translation available.
BC133625 mRNA Translation: AAI33626.1
RefSeqiNP_001075919.1, NM_001082450.1
UniGeneiBt.104283

3D structure databases

SMRiA2VE87
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000056469

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000065609; ENSBTAP00000056469; ENSBTAG00000046604
GeneIDi539079
KEGGibta:539079

Organism-specific databases

CTDi26585
VGNCiVGNC:29633 GREM1

Phylogenomic databases

eggNOGiENOG410IG3Z Eukaryota
ENOG4111HEF LUCA
GeneTreeiENSGT00510000046909
HOGENOMiHOG000237358
HOVERGENiHBG051837
OMAiRVKECRC
OrthoDBiEOG091G0GL9
TreeFamiTF106445

Gene expression databases

BgeeiENSBTAG00000046604 Expressed in 8 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR004133 DAN
IPR017159 Gremlin-1/2
PfamiView protein in Pfam
PF03045 DAN, 1 hit
PIRSFiPIRSF037254 Gremlin_precursor, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2VE87_BOVIN
AccessioniPrimary (citable) accession number: A2VE87
Entry historyiIntegrated into UniProtKB/TrEMBL: March 20, 2007
Last sequence update: March 20, 2007
Last modified: September 12, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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