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UniProtKB - A2VE31 (S38A2_BOVIN)
Protein
Sodium-coupled neutral amino acid transporter 2
Gene
SLC38A2
Organism
Bos taurus (Bovine)
Status
Functioni
Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta (By similarity).
By similarityActivity regulationi
Inhibited by N-methyl-D-glucamine and choline.By similarity
GO - Molecular functioni
- amino acid transmembrane transporter activity Source: GO_Central
- L-glutamine transmembrane transporter activity Source: GO_Central
- neutral amino acid:sodium symporter activity Source: Ensembl
GO - Biological processi
- amino acid transmembrane transport Source: GO_Central
- cellular response to arsenite(3-) Source: Ensembl
- glutamine transport Source: GO_Central
- positive regulation of RNA splicing Source: Ensembl
- regulation of cellular response to stress Source: Ensembl
Keywordsi
Biological process | Amino-acid transport, Ion transport, Sodium transport, Symport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-BTA-210500, Glutamate Neurotransmitter Release Cycle R-BTA-352230, Amino acid transport across the plasma membrane |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium-coupled neutral amino acid transporter 2Alternative name(s): Amino acid transporter A2 Protein 40-9-1 Solute carrier family 38 member 2 System A amino acid transporter 2 System A transporter 1 System N amino acid transporter 2 |
Gene namesi | Name:SLC38A2 Synonyms:SNAT2 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000011105 |
VGNCi | VGNC:34849, SLC38A2 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Note: Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes. May localize to an endosomal compartment. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal.By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 76 | CytoplasmicSequence analysisAdd BLAST | 76 | |
Transmembranei | 77 – 97 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 98 – 102 | ExtracellularSequence analysis | 5 | |
Transmembranei | 103 – 123 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 124 – 158 | CytoplasmicSequence analysisAdd BLAST | 35 | |
Transmembranei | 159 – 179 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 180 – 188 | ExtracellularSequence analysis | 9 | |
Transmembranei | 189 – 209 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 210 – 217 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 218 – 238 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 239 – 292 | ExtracellularSequence analysisAdd BLAST | 54 | |
Transmembranei | 293 – 313 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 314 – 329 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 330 – 350 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 351 – 371 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 372 – 392 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 393 – 413 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 414 – 434 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 435 – 436 | ExtracellularSequence analysis | 2 | |
Transmembranei | 437 – 457 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 458 – 474 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 475 – 495 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 496 – 506 | ExtracellularSequence analysisAdd BLAST | 11 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000311368 | 1 – 506 | Sodium-coupled neutral amino acid transporter 2Add BLAST | 506 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 12 | PhosphoserineBy similarity | 1 | |
Modified residuei | 21 | PhosphoserineBy similarity | 1 | |
Modified residuei | 22 | PhosphoserineBy similarity | 1 | |
Modified residuei | 55 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 245 ↔ 281 | PROSITE-ProRule annotation | ||
Glycosylationi | 258 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 274 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | A2VE31 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000011105, Expressed in spermatocyte and 97 other tissues |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 96 | Regulates protein turnover upon amino acid deprivationBy similarityAdd BLAST | 96 | |
Regioni | 1 – 23 | DisorderedSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the amino acid/polyamine transporter 2 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1305, Eukaryota |
GeneTreei | ENSGT00940000155486 |
HOGENOMi | CLU_009020_0_1_1 |
InParanoidi | A2VE31 |
OMAi | RKWRWDL |
OrthoDBi | 1109791at2759 |
TreeFami | TF328787 |
Family and domain databases
InterProi | View protein in InterPro IPR013057, AA_transpt_TM |
Pfami | View protein in Pfam PF01490, Aa_trans, 1 hit |
i Sequence
Sequence statusi: Complete.
A2VE31-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKAEMGRFN ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN
60 70 80 90 100
FLLESNLGKK KYETDFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG
110 120 130 140 150
IALFIILLTF VSIFSLYSVH LLLKTANEGG SLLYEQLGHK AFGMVGKLTA
160 170 180 190 200
SGSITMQNIG AMSSYLFIVK YELPLVIQAL MNIEDTNGLW YLNGDYLVLL
210 220 230 240 250
VSLVLILPLS LLRNLGYLGY TSGLSLLCMM FFLIVVIFKK FQISCPAEIA
260 270 280 290 300
FLVNETVNSS LTQPATFLPD MGFNRTESDS CQPRYFIFNS QTVYAVPILT
310 320 330 340 350
FSFVCHPAIL PIYEELKGRS RRRMMNVSKI SFFAMFLMYL LAALFGYLTF
360 370 380 390 400
YGHVESELLH TYSSVMETDI LLLIVRLAVL VAVTLTVPVV IFPIRSSITH
410 420 430 440 450
LLCASKEFSW WRHSVITVSI LVFTNLLVIF VPNIRDIFGF IGASAAAMLI
460 470 480 490 500
FILPSAFYIK LVKKEPMKSV QKIGAMFFLL SGIVVMTGSM ALIVLDWVHN
APGGGH
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 409 | S → N in CAC51429 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC133547 mRNA Translation: AAI33548.1 AJ344100 mRNA Translation: CAC51429.1 |
RefSeqi | NP_001075893.1, NM_001082424.1 |
Genome annotation databases
Ensembli | ENSBTAT00000014749; ENSBTAP00000014749; ENSBTAG00000011105 |
GeneIDi | 338044 |
KEGGi | bta:338044 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC133547 mRNA Translation: AAI33548.1 AJ344100 mRNA Translation: CAC51429.1 |
RefSeqi | NP_001075893.1, NM_001082424.1 |
3D structure databases
SMRi | A2VE31 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000014749 |
Proteomic databases
PaxDbi | A2VE31 |
Genome annotation databases
Ensembli | ENSBTAT00000014749; ENSBTAP00000014749; ENSBTAG00000011105 |
GeneIDi | 338044 |
KEGGi | bta:338044 |
Organism-specific databases
CTDi | 54407 |
VEuPathDBi | HostDB:ENSBTAG00000011105 |
VGNCi | VGNC:34849, SLC38A2 |
Phylogenomic databases
eggNOGi | KOG1305, Eukaryota |
GeneTreei | ENSGT00940000155486 |
HOGENOMi | CLU_009020_0_1_1 |
InParanoidi | A2VE31 |
OMAi | RKWRWDL |
OrthoDBi | 1109791at2759 |
TreeFami | TF328787 |
Enzyme and pathway databases
Reactomei | R-BTA-210500, Glutamate Neurotransmitter Release Cycle R-BTA-352230, Amino acid transport across the plasma membrane |
Gene expression databases
Bgeei | ENSBTAG00000011105, Expressed in spermatocyte and 97 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR013057, AA_transpt_TM |
Pfami | View protein in Pfam PF01490, Aa_trans, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S38A2_BOVIN | |
Accessioni | A2VE31Primary (citable) accession number: A2VE31 Secondary accession number(s): Q95M41 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | March 20, 2007 | |
Last modified: | February 23, 2022 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families