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Protein
Submitted name:

Betacellulin

Gene

BTC

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-1227986 Signaling by ERBB2
R-BTA-1236394 Signaling by ERBB4
R-BTA-1250196 SHC1 events in ERBB2 signaling
R-BTA-1250342 PI3K events in ERBB4 signaling
R-BTA-1250347 SHC1 events in ERBB4 signaling
R-BTA-1257604 PIP3 activates AKT signaling
R-BTA-1963640 GRB2 events in ERBB2 signaling
R-BTA-1963642 PI3K events in ERBB2 signaling
R-BTA-5673001 RAF/MAP kinase cascade
R-BTA-6785631 ERBB2 Regulates Cell Motility
R-BTA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-BTA-8847993 ERBB2 Activates PTK6 Signaling
R-BTA-8863795 Downregulation of ERBB2 signaling

Names & Taxonomyi

Protein namesi
Submitted name:
BetacellulinImported
Submitted name:
ProbetacellulinImported
Gene namesi
Name:BTCImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Organism-specific databases

VGNCiVGNC:26593 BTC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei119 – 145HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_501408355532 – 178Sequence analysisAdd BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi95 ↔ 104PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSBTAG00000004237 Expressed in 7 organ(s), highest expression level in skeletal muscle tissue

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 105EGF-likeInterPro annotationAdd BLAST41

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IWUI Eukaryota
ENOG41126JP LUCA
GeneTreeiENSGT00730000110951
HOVERGENiHBG004905
KOiK09783
OMAiILHCVVA
OrthoDBiEOG091G0RK4
TreeFamiTF332938

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR015497 EGF_rcpt_ligand
PANTHERiPTHR10740 PTHR10740, 1 hit
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

A2VE27-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARAAPGSGA SPLPLLPALA LGLVILHCVL ADGNSTRSPE DDGLLCGDHA
60 70 80 90 100
ENCPATTTQP KRRGHFSRCP KQYKHYCIKG RCRFVVAEQT PSCVCDEGYA
110 120 130 140 150
GARCERVDLF YLRGDRGQIL VICLIAVMVI FIILVVSICT CCHPLRKRRK
160 170
RRKKEEEMET LGKDITPIND DIQETSIA
Length:178
Mass (Da):19,654
Last modified:March 20, 2007 - v1
Checksum:i4F8B7C13FB1F2A11
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9TTC5BTC_BOVIN
Probetacellulin
BTC
178Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02018100 Genomic DNA No translation available.
DAAA02018101 Genomic DNA No translation available.
BC133541 mRNA Translation: AAI33542.1
RefSeqiNP_776321.2, NM_173896.2
UniGeneiBt.236

Genome annotation databases

EnsembliENSBTAT00000005549; ENSBTAP00000005549; ENSBTAG00000004237
GeneIDi280737
KEGGibta:280737

Similar proteinsi

Entry informationi

Entry nameiA2VE27_BOVIN
AccessioniPrimary (citable) accession number: A2VE27
Entry historyiIntegrated into UniProtKB/TrEMBL: March 20, 2007
Last sequence update: March 20, 2007
Last modified: September 12, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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