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Protein

Probable palmitoyltransferase ZDHHC21

Gene

ZDHHC21

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity).By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-BTA-203615 eNOS activation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC21 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 21
Short name:
DHHC-21
Gene namesi
Name:ZDHHC21
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 8

Organism-specific databases

VGNCiVGNC:37137 ZDHHC21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002886831 – 265Probable palmitoyltransferase ZDHHC21Add BLAST265

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiA2VDT6
PRIDEiA2VDT6

Expressioni

Gene expression databases

BgeeiENSBTAG00000006197

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008139

Structurei

3D structure databases

SMRiA2VDT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 140DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00880000137864
HOGENOMiHOG000013210
HOVERGENiHBG055594
InParanoidiA2VDT6
KOiK18932
OMAiCNMMRPK
OrthoDBiEOG091G0DM3
TreeFamiTF319798

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

A2VDT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLRIHFVVD PHGWCCMGLI VFVWLYNFFL IPKIVLFPHY EEGHIPGILI
60 70 80 90 100
IIFYGIAMFC LVALVRASIT DPGRLPENPK IPHGEREFWE LCNKCNLMRP
110 120 130 140 150
KRSHHCSRCG HCVRRMDHHC PWINNCVGED NHWLFLQLCF YTELLTCYAL
160 170 180 190 200
MFSFCHYYYF LPLKKRNLDL FVVRHELAIM RLAAFMGITM LVGITGLFYT
210 220 230 240 250
QLIGIITDTT SIEKMSNCCE EISRPRKPWQ QTFSEVFGTR WKILWFIPFR
260
RRQPLRVPYH FANHV
Length:265
Mass (Da):31,463
Last modified:March 20, 2007 - v1
Checksum:iD32AE447AEAEAC0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133395 mRNA Translation: AAI33396.1
RefSeqiNP_001075003.1, NM_001081534.1
XP_005209984.1, XM_005209927.3
XP_010806101.1, XM_010807799.2
XP_015327924.1, XM_015472438.1
UniGeneiBt.52087

Genome annotation databases

EnsembliENSBTAT00000008139; ENSBTAP00000008139; ENSBTAG00000006197
GeneIDi535814
KEGGibta:535814

Similar proteinsi

Entry informationi

Entry nameiZDH21_BOVIN
AccessioniPrimary (citable) accession number: A2VDT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 20, 2007
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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