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UniProtKB - A2VDS1 (SCLY_BOVIN)
Protein
Selenocysteine lyase
Gene
SCLY
Organism
Bos taurus (Bovine)
Status
Functioni
Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium.
By similarityCatalytic activityi
Cofactori
pyridoxal 5'-phosphateBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 380 | S-selanylcysteine intermediateBy similarity | 1 |
GO - Molecular functioni
- selenocysteine lyase activity Source: UniProtKB-EC
- transferase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Lyase, Transferase |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
Reactomei | R-BTA-2408508, Metabolism of ingested SeMet, Sec, MeSec into H2Se |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:SCLY |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000017826 |
VGNCi | VGNC:55677, SCLY |
Subcellular locationi
Cytoplasm and Cytosol
- cytosol By similarity
Cytosol
- cytosol Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: Ensembl
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317011 | 1 – 437 | Selenocysteine lyaseAdd BLAST | 437 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 252 | N6-(pyridoxal phosphate)lysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | A2VDS1 |
PeptideAtlasi | A2VDS1 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000017826, Expressed in liver and 97 other tissues |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000013719 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 30 | DisorderedSequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 23 | Basic and acidic residuesSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.Curated
Phylogenomic databases
eggNOGi | KOG1549, Eukaryota |
GeneTreei | ENSGT00940000157773 |
HOGENOMi | CLU_003433_0_0_1 |
InParanoidi | A2VDS1 |
OMAi | IIYGQSE |
OrthoDBi | 697150at2759 |
TreeFami | TF313550 |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR000192, Aminotrans_V_dom IPR016454, Cysteine_dSase IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small |
Pfami | View protein in Pfam PF00266, Aminotran_5, 1 hit |
PIRSFi | PIRSF005572, NifS, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
i Sequence
Sequence statusi: Complete.
A2VDS1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEAAGARNRD ARSRAEKSPP ESRKVYMDYN ATTPLEPEVI EAMTEAMREA
60 70 80 90 100
WGNPSSSYPA GRKAKEIINT ARENLAKMIG GQPQDVIFTS GGTESNNLVI
110 120 130 140 150
QSVVKHFHKV HAANGDTGGH PNPVDGALPH IITCTVEHDS IRLPLEHLRE
160 170 180 190 200
ERVAEVTFVP VSKVNGQVEA EDILAAVRPA TCLVTIMLAN NETGVIMPVP
210 220 230 240 250
EISRRVRALN QQRVAGGLPG VLVHTDAAQA LGKQRVDVRD LGVDFLTIVG
260 270 280 290 300
HKFYGPRIGA LYVRGLGEHT PLYPMLFGGG QERNFRPGTE NTPMIAGLGK
310 320 330 340 350
AAELVAENGE AYEAHMRGVR DYLEERLAAE FGERIHLNSQ FPGAERLPNT
360 370 380 390 400
CNFSIRGPQL QGRAVLAQCR TLLASVGAAC HSDLGDRPSP VLLSCGVPVD
410 420 430
VARNAIRLSV GRSSTRAEVD LVVQDLKQAV ARLEGQA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC133375 mRNA Translation: AAI33376.1 |
RefSeqi | NP_001077273.1, NM_001083804.1 |
Genome annotation databases
Ensembli | ENSBTAT00000013719; ENSBTAP00000013719; ENSBTAG00000017826 |
GeneIDi | 790815 |
KEGGi | bta:790815 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC133375 mRNA Translation: AAI33376.1 |
RefSeqi | NP_001077273.1, NM_001083804.1 |
3D structure databases
AlphaFoldDBi | A2VDS1 |
SMRi | A2VDS1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000013719 |
Proteomic databases
PaxDbi | A2VDS1 |
PeptideAtlasi | A2VDS1 |
Genome annotation databases
Ensembli | ENSBTAT00000013719; ENSBTAP00000013719; ENSBTAG00000017826 |
GeneIDi | 790815 |
KEGGi | bta:790815 |
Organism-specific databases
CTDi | 51540 |
VEuPathDBi | HostDB:ENSBTAG00000017826 |
VGNCi | VGNC:55677, SCLY |
Phylogenomic databases
eggNOGi | KOG1549, Eukaryota |
GeneTreei | ENSGT00940000157773 |
HOGENOMi | CLU_003433_0_0_1 |
InParanoidi | A2VDS1 |
OMAi | IIYGQSE |
OrthoDBi | 697150at2759 |
TreeFami | TF313550 |
Enzyme and pathway databases
Reactomei | R-BTA-2408508, Metabolism of ingested SeMet, Sec, MeSec into H2Se |
Gene expression databases
Bgeei | ENSBTAG00000017826, Expressed in liver and 97 other tissues |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR000192, Aminotrans_V_dom IPR016454, Cysteine_dSase IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small |
Pfami | View protein in Pfam PF00266, Aminotran_5, 1 hit |
PIRSFi | PIRSF005572, NifS, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SCLY_BOVIN | |
Accessioni | A2VDS1Primary (citable) accession number: A2VDS1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | March 20, 2007 | |
Last modified: | May 25, 2022 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families