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Protein

Zinc finger protein 420

Gene

ZNF420

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri138 – 160C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri166 – 188C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri194 – 216C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri222 – 244C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri614 – 636C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri642 – 664C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 420
Gene namesi
Name:ZNF420
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003472411 – 687Zinc finger protein 420Add BLAST687

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiA2VDQ7
PRIDEiA2VDQ7

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000049685

Structurei

3D structure databases

ProteinModelPortaliA2VDQ7
SMRiA2VDQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 95KRABPROSITE-ProRule annotationAdd BLAST90

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri138 – 160C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri166 – 188C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri194 – 216C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri222 – 244C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri614 – 636C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri642 – 664C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiA2VDQ7
KOiK09228

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 18 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 19 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

Sequencei

Sequence statusi: Complete.

A2VDQ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQRSVMFRD VAIDFSQEEW DCLDSAQRDL YRDVMLENYS NLVSLDLPSR
60 70 80 90 100
GANKLLSPKK DIYETGLSQW EMSARLENCD LENSSSRDYL EVKGTLEKQQ
110 120 130 140 150
ENQAYFSQGM IIYDNMSIFN QHAYLSQHPR CHSTEKPYKC KECGKAFRRA
160 170 180 190 200
SHLTQHQSIH TGEKPYECKQ CGKAFSRDSQ LSLHQRLHTG EKPYACKECG
210 220 230 240 250
KAFTQSSQLI LHHRIHTGEK PYKCEECGKA FIRSSQLTRH QKVHTGEKPY
260 270 280 290 300
ECKECGKAFT QNSQLTLHQR LHTGEKLYEC KECRKVFTQL SQLILHKRIH
310 320 330 340 350
TGEKPYECKE CGKAFICGSQ LSQHQKIHNG EKPYECQECG KAFIRGSLLM
360 370 380 390 400
QHQRIHTGEK PYKCEECGKA FIRGSQLTQH QRIHTNEKPY ECKECGKTFS
410 420 430 440 450
HGSQLTQHQR IHTGEKPYQC KECGKAFNRG SLLTRHQRIH TGEKPYECKE
460 470 480 490 500
CGKTFSRGSE LTQHERIHTG EKPYECKECG KSFIRGSQLT QHQRIHTGEK
510 520 530 540 550
PYECKECRMA FTQSSHLSQH QRLHTGEKPY VCNECGKAFA RGLLLIQHQR
560 570 580 590 600
IHTGEKPYQC KECGKAFIRG SQLTQHQRIH TGEKPYGCKE CGKAFSHGSQ
610 620 630 640 650
LTLHQRIHTG EKPYECKECR KAFTQSSHLS RHQRVHTGEK PYQCRECGKA
660 670 680
FTRGSQLTQH QRIHISEKSF AYKECGIDFS HDSQVYI
Length:687
Mass (Da):79,571
Last modified:March 20, 2007 - v1
Checksum:i0D7D12A1B44B47DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133352 mRNA Translation: AAI33353.1
RefSeqiNP_001096022.1, NM_001102552.1
UniGeneiBt.35008

Genome annotation databases

GeneIDi100124518
KEGGibta:100124518

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC133352 mRNA Translation: AAI33353.1
RefSeqiNP_001096022.1, NM_001102552.1
UniGeneiBt.35008

3D structure databases

ProteinModelPortaliA2VDQ7
SMRiA2VDQ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000049685

Proteomic databases

PaxDbiA2VDQ7
PRIDEiA2VDQ7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100124518
KEGGibta:100124518

Organism-specific databases

CTDi147923

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiA2VDQ7
KOiK09228

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 18 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 19 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN420_BOVIN
AccessioniPrimary (citable) accession number: A2VDQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 20, 2007
Last modified: November 7, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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