UniProtKB - A2VDJ0 (T131L_HUMAN)
Protein
Transmembrane protein 131-like
Gene
TMEM131L
Organism
Homo sapiens (Human)
Status
Functioni
Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.1 Publication
GO - Biological processi
- negative regulation of canonical Wnt signaling pathway Source: UniProtKB
- negative regulation of immature T cell proliferation in thymus Source: UniProtKB
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | A2VDJ0 |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 131-likeImported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29146, TMEM131L |
MIMi | 616243, gene |
neXtProti | NX_A2VDJ0 |
VEuPathDBi | HostDB:ENSG00000121210.15 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Curated
Other locations
- Cytoplasm 1 Publication
Note: During intrathymic development, resides in punctate cytoplasmic structures in DN1 and DN2 cells. In DN3 cells, found in large crescent-shaped membrane structures, which preferentially localize in cell-to-cell contact zones.1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum 1 Publication
Note: Transmembrane localization is essential for Wnt signaling inhibition.1 Publication
Other locations
- Cytoplasm 1 Publication
Note: Scattered throughout the cytoplasm in small-sized punctate structures.1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 41 – 869 | ExtracellularSequence analysisAdd BLAST | 829 | |
Transmembranei | 870 – 890 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 891 – 1609 | CytoplasmicSequence analysisAdd BLAST | 719 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 23240 |
OpenTargetsi | ENSG00000121210 |
PharmGKBi | PA128394615 |
Miscellaneous databases
Pharosi | A2VDJ0, Tbio |
Genetic variation databases
BioMutai | TMEM131L |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 40 | Sequence analysisAdd BLAST | 40 | |
ChainiPRO_0000328865 | 41 – 1609 | Transmembrane protein 131-likeAdd BLAST | 1569 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 343 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 439 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 522 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 593 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 709 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 846 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1122 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | A2VDJ0 |
jPOSTi | A2VDJ0 |
MassIVEi | A2VDJ0 |
MaxQBi | A2VDJ0 |
PaxDbi | A2VDJ0 |
PeptideAtlasi | A2VDJ0 |
PRIDEi | A2VDJ0 |
ProteomicsDBi | 541 [A2VDJ0-1] 542 [A2VDJ0-2] 543 [A2VDJ0-3] 544 [A2VDJ0-5] |
PTM databases
GlyGeni | A2VDJ0, 10 sites |
iPTMneti | A2VDJ0 |
PhosphoSitePlusi | A2VDJ0 |
SwissPalmi | A2VDJ0 |
Expressioni
Tissue specificityi
Expressed in thymocytes.1 Publication
Developmental stagei
During intrathymic development, transcript levels strongly increase from pro-DN1 thymocytes to DN3a cells, in which they peak, and drop immediately after beta-selection in their DN3b successors. The subcellular location of the protein also varies, from punctate cytoplasmic structures in DN1 and DN2 cells to large crescent-shaped membrane structures in DN3 cells, which preferentially localize in cell-to-cell contact zones.1 Publication
Gene expression databases
Bgeei | ENSG00000121210, Expressed in secondary oocyte and 206 other tissues |
ExpressionAtlasi | A2VDJ0, baseline and differential |
Genevisiblei | A2VDJ0, HS |
Organism-specific databases
HPAi | ENSG00000121210, Tissue enhanced (lymphoid) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 116844, 42 interactors |
IntActi | A2VDJ0, 4 interactors |
STRINGi | 9606.ENSP00000386787 |
Miscellaneous databases
RNActi | A2VDJ0, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 696 – 916 | Required for Wnt-signaling inhibition and LRP6 degradation1 PublicationAdd BLAST | 221 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 910 – 913 | Poly-Ser | 4 | |
Compositional biasi | 1302 – 1331 | Ser-richAdd BLAST | 30 |
Sequence similaritiesi
Belongs to the TMEM131 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3620, Eukaryota |
GeneTreei | ENSGT00530000063614 |
InParanoidi | A2VDJ0 |
OMAi | NMNYHNG |
OrthoDBi | 45814at2759 |
PhylomeDBi | A2VDJ0 |
TreeFami | TF321435 |
Family and domain databases
InterProi | View protein in InterPro IPR039877, TMEM131-like IPR022113, TMEM131-like_dom |
PANTHERi | PTHR22050, PTHR22050, 1 hit |
Pfami | View protein in Pfam PF12371, TMEM131_like, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: A2VDJ0-1) [UniParc]FASTAAdd to basket
Also known as: L1 Publication
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGLRRPQPG CYCRTAAAVN LLLGVFQVLL PCCRPGGAQG QAIEPLPNVV
60 70 80 90 100
ELWQAEEGEL LLPTQGDSEE GLEEPSQEQS FSDKLFSGKG LHFQPSVLDF
110 120 130 140 150
GIQFLGHPVA KILHAYNPSR DSEVVVNSVF AAAGHFHVPP VPCRVIPAMG
160 170 180 190 200
KTSFRIIFLP TEEGSIESSL FINTSSYGVL SYHVSGIGTR RISTEGSAKQ
210 220 230 240 250
LPNAYFLLPK VQSIQLSQMQ AETTNTSLLQ VQLECSLHNK VCQQLKGCYL
260 270 280 290 300
ESDDVLRLQM SIMVTMENFS KEFEENTQHL LDHLSIVYVA TDESETSDDS
310 320 330 340 350
AVNMYILHSG NSLIWIQDIR HFSQRDALSL QFEPVLLPTS TTNFTKIASF
360 370 380 390 400
TCKATSCDSG IIEDVKKTTH TPTLKACLFS SVAQGYFRMD SSATQFHIET
410 420 430 440 450
HENTSGLWSI WYRNHFDRSV VLNDVFLSKE TKHMLKILNF TGPLFLPPGC
460 470 480 490 500
WNIFSLKLAV KDIAINLFTN VFLTTNIGAI FAIPLQIYSA PTKEGSLGFE
510 520 530 540 550
VIAHCGMHYF MGKSKAGNPN WNGSLSLDQS TWNVDSELAN KLYERWKKYK
560 570 580 590 600
NGDVCKRNVL GTTRFAHLKK SKESESFVFF LPRLIAEPGL MLNFSATALR
610 620 630 640 650
SRMIKYFVVQ NPSSWPVSLQ LLPLSLYPKP EALVHLLHRW FGTDMQMINF
660 670 680 690 700
TTGEFQLTEA CPYLGTHSEE SRFGILHLHL QPLEMKRVGV VFTPADYGKV
710 720 730 740 750
TSLILIRNNL TVIDMIGVEG FGARELLKVG GRLPGAGGSL RFKVPESTLM
760 770 780 790 800
DCRRQLKDSK QILSITKNFK VENIGPLPIT VSSLKINGYN CQGYGFEVLD
810 820 830 840 850
CHQFSLDPNT SRDISIVFTP DFTSSWVIRD LSLVTAADLE FRFTLNVTLP
860 870 880 890 900
HHLLPLCADV VPGPSWEESF WRLTVFFVSL SLLGVILIAF QQAQYILMEF
910 920 930 940 950
MKTRQRQNAS SSSQQNNGPM DVISPHSYKS NCKNFLDTYG PSDKGRGKNC
960 970 980 990 1000
LPVNTPQSRI QNAAKRSPAT YGHSQKKHKC SVYYSKHKTS TAAASSTSTT
1010 1020 1030 1040 1050
TEEKQTSPLG SSLPAAKEDI CTDAMRENWI SLRYASGINV NLQKNLTLPK
1060 1070 1080 1090 1100
NLLNKEENTL KNTIVFSNPS SECSMKEGIQ TCMFPKETDI KTSENTAEFK
1110 1120 1130 1140 1150
ERELCPLKTS KKLPENHLPR NSPQYHQPDL PEISRKNNGN NQQVPVKNEV
1160 1170 1180 1190 1200
DHCENLKKVD TKPSSEKKIH KTSREDMFSE KQDIPFVEQE DPYRKKKLQE
1210 1220 1230 1240 1250
KREGNLQNLN WSKSRTCRKN KKRGVAPVSR PPEQSDLKLV CSDFERSELS
1260 1270 1280 1290 1300
SDINVRSWCI QESTREVCKA DAEIASSLPA AQREAEGYYQ KPEKKCVDKF
1310 1320 1330 1340 1350
CSDSSSDCGS SSGSVRASRG SWGSWSSTSS SDGDKKPMVD AQHFLPAGDS
1360 1370 1380 1390 1400
VSQNDFPSEA PISLNLSHNI CNPMTVNSLP QYAEPSCPSL PAGPTGVEED
1410 1420 1430 1440 1450
KGLYSPGDLW PTPPVCVTSS LNCTLENGVP CVIQESAPVH NSFIDWSATC
1460 1470 1480 1490 1500
EGQFSSAYCP LELNDYNAFP EENMNYANGF PCPADVQTDF IDHNSQSTWN
1510 1520 1530 1540 1550
TPPNMPAAWG HASFISSPPY LTSTRSLSPM SGLFGSIWAP QSDVYENCCP
1560 1570 1580 1590 1600
INPTTEHSTH MENQAVVCKE YYPGFNPFRA YMNLDIWTTT ANRNANFPLS
RDSSYCGNV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y2M0 | H0Y2M0_HUMAN | Transmembrane protein 131-like | TMEM131L | 1,387 | Annotation score: | ||
F8WEQ2 | F8WEQ2_HUMAN | Transmembrane protein 131-like | TMEM131L | 71 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 171 | F → S in BAG52515 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042551 | 604 | I → V. Corresponds to variant dbSNP:rs7669418Ensembl. | 1 | |
Natural variantiVAR_042552 | 645 | M → T1 PublicationCorresponds to variant dbSNP:rs17370297Ensembl. | 1 | |
Natural variantiVAR_042553 | 1110 | S → Y. Corresponds to variant dbSNP:rs755078Ensembl. | 1 | |
Natural variantiVAR_042554 | 1254 | N → S. Corresponds to variant dbSNP:rs35018723Ensembl. | 1 | |
Natural variantiVAR_042555 | 1392 | A → P. Corresponds to variant dbSNP:rs35543386Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_032826 | 1 – 370 | Missing in isoform 2. 1 PublicationAdd BLAST | 370 | |
Alternative sequenceiVSP_057633 | 1 – 148 | Missing in isoform 5. Add BLAST | 148 | |
Alternative sequenceiVSP_032827 | 353 | K → KA in isoform 3, isoform 4 and isoform 5. 3 Publications | 1 | |
Alternative sequenceiVSP_032828 | 371 – 380 | TPTLKACLFS → MLLVLECVLF in isoform 2. 1 Publication | 10 | |
Alternative sequenceiVSP_032829 | 557 – 640 | Missing in isoform 3. 1 PublicationAdd BLAST | 84 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136932 mRNA Translation: CAB66866.1 AC106865 Genomic DNA No translation available. AC116648 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04957.1 CH471056 Genomic DNA Translation: EAX04958.1 AK092270 mRNA Translation: BAG52515.1 BC044932 mRNA Translation: AAH44932.1 BC131505 mRNA Translation: AAI31506.1 AB023139 mRNA Translation: BAA76766.1 |
CCDSi | CCDS3783.2 [A2VDJ0-1] CCDS47148.1 [A2VDJ0-5] |
RefSeqi | NP_001124479.1, NM_001131007.1 [A2VDJ0-5] NP_056011.3, NM_015196.3 [A2VDJ0-1] |
Genome annotation databases
Ensembli | ENST00000409663; ENSP00000386574; ENSG00000121210 [A2VDJ0-1] ENST00000409959; ENSP00000386787; ENSG00000121210 [A2VDJ0-5] |
GeneIDi | 23240 |
KEGGi | hsa:23240 |
UCSCi | uc003inm.5, human [A2VDJ0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136932 mRNA Translation: CAB66866.1 AC106865 Genomic DNA No translation available. AC116648 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04957.1 CH471056 Genomic DNA Translation: EAX04958.1 AK092270 mRNA Translation: BAG52515.1 BC044932 mRNA Translation: AAH44932.1 BC131505 mRNA Translation: AAI31506.1 AB023139 mRNA Translation: BAA76766.1 |
CCDSi | CCDS3783.2 [A2VDJ0-1] CCDS47148.1 [A2VDJ0-5] |
RefSeqi | NP_001124479.1, NM_001131007.1 [A2VDJ0-5] NP_056011.3, NM_015196.3 [A2VDJ0-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116844, 42 interactors |
IntActi | A2VDJ0, 4 interactors |
STRINGi | 9606.ENSP00000386787 |
PTM databases
GlyGeni | A2VDJ0, 10 sites |
iPTMneti | A2VDJ0 |
PhosphoSitePlusi | A2VDJ0 |
SwissPalmi | A2VDJ0 |
Genetic variation databases
BioMutai | TMEM131L |
Proteomic databases
EPDi | A2VDJ0 |
jPOSTi | A2VDJ0 |
MassIVEi | A2VDJ0 |
MaxQBi | A2VDJ0 |
PaxDbi | A2VDJ0 |
PeptideAtlasi | A2VDJ0 |
PRIDEi | A2VDJ0 |
ProteomicsDBi | 541 [A2VDJ0-1] 542 [A2VDJ0-2] 543 [A2VDJ0-3] 544 [A2VDJ0-5] |
Protocols and materials databases
Antibodypediai | 57011, 55 antibodies |
Genome annotation databases
Ensembli | ENST00000409663; ENSP00000386574; ENSG00000121210 [A2VDJ0-1] ENST00000409959; ENSP00000386787; ENSG00000121210 [A2VDJ0-5] |
GeneIDi | 23240 |
KEGGi | hsa:23240 |
UCSCi | uc003inm.5, human [A2VDJ0-1] |
Organism-specific databases
CTDi | 23240 |
DisGeNETi | 23240 |
GeneCardsi | TMEM131L |
HGNCi | HGNC:29146, TMEM131L |
HPAi | ENSG00000121210, Tissue enhanced (lymphoid) |
MIMi | 616243, gene |
neXtProti | NX_A2VDJ0 |
OpenTargetsi | ENSG00000121210 |
PharmGKBi | PA128394615 |
VEuPathDBi | HostDB:ENSG00000121210.15 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3620, Eukaryota |
GeneTreei | ENSGT00530000063614 |
InParanoidi | A2VDJ0 |
OMAi | NMNYHNG |
OrthoDBi | 45814at2759 |
PhylomeDBi | A2VDJ0 |
TreeFami | TF321435 |
Enzyme and pathway databases
PathwayCommonsi | A2VDJ0 |
Miscellaneous databases
BioGRID-ORCSi | 23240, 7 hits in 890 CRISPR screens |
ChiTaRSi | KIAA0922, human |
GeneWikii | KIAA0922 |
GenomeRNAii | 23240 |
Pharosi | A2VDJ0, Tbio |
PROi | PR:A2VDJ0 |
RNActi | A2VDJ0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000121210, Expressed in secondary oocyte and 206 other tissues |
ExpressionAtlasi | A2VDJ0, baseline and differential |
Genevisiblei | A2VDJ0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039877, TMEM131-like IPR022113, TMEM131-like_dom |
PANTHERi | PTHR22050, PTHR22050, 1 hit |
Pfami | View protein in Pfam PF12371, TMEM131_like, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | T131L_HUMAN | |
Accessioni | A2VDJ0Primary (citable) accession number: A2VDJ0 Secondary accession number(s): B3KRV3 Q9Y2D7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | April 8, 2008 | |
Last modified: | February 10, 2021 | |
This is version 111 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM