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UniProtKB - A2VDJ0 (T131L_HUMAN)

Entry version 113 (02 Jun 2021)
Sequence version 2 (08 Apr 2008)
Previous versions | rss
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Protein

Transmembrane protein 131-like

Gene

TMEM131L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		A2VDJ0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 131-likeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM131LImported
Synonyms:KIAA0922Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29146, TMEM131L

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616243, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A2VDJ0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000121210.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini41 – 869ExtracellularSequence analysisAdd BLAST829
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei870 – 890HelicalSequence analysisAdd BLAST21
Topological domaini891 – 1609CytoplasmicSequence analysisAdd BLAST719

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23240

Open Targets

More...OpenTargetsi		ENSG00000121210

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA128394615

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A2VDJ0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM131L

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 40Sequence analysisAdd BLAST40
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032886541 – 1609Transmembrane protein 131-likeAdd BLAST1569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi522N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi593N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi709N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi846N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1122PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A2VDJ0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A2VDJ0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		A2VDJ0

MaxQB - The MaxQuant DataBase

More...MaxQBi		A2VDJ0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A2VDJ0

PeptideAtlas

More...PeptideAtlasi		A2VDJ0

PRoteomics IDEntifications database

More...PRIDEi		A2VDJ0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		541 [A2VDJ0-1]
542 [A2VDJ0-2]
543 [A2VDJ0-3]
544 [A2VDJ0-5]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		A2VDJ0, 10 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A2VDJ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A2VDJ0

SwissPalm database of S-palmitoylation events

More...SwissPalmi		A2VDJ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in thymocytes.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

During intrathymic development, transcript levels strongly increase from pro-DN1 thymocytes to DN3a cells, in which they peak, and drop immediately after beta-selection in their DN3b successors. The subcellular location of the protein also varies, from punctate cytoplasmic structures in DN1 and DN2 cells to large crescent-shaped membrane structures in DN3 cells, which preferentially localize in cell-to-cell contact zones.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000121210, Expressed in secondary oocyte and 206 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A2VDJ0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A2VDJ0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000121210, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116844, 47 interactors

Protein interaction database and analysis system

More...IntActi		A2VDJ0, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000386787

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A2VDJ0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni696 – 916Required for Wnt-signaling inhibition and LRP6 degradation1 PublicationAdd BLAST221
Regioni946 – 974DisorderedSequence analysisAdd BLAST29
Regioni991 – 1014DisorderedSequence analysisAdd BLAST24
Regioni1108 – 1144DisorderedSequence analysisAdd BLAST37
Regioni1159 – 1178DisorderedSequence analysisAdd BLAST20
Regioni1304 – 1340DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi951 – 969Polar residuesSequence analysisAdd BLAST19
Compositional biasi991 – 1012Polar residuesSequence analysisAdd BLAST22
Compositional biasi1116 – 1144Polar residuesSequence analysisAdd BLAST29
Compositional biasi1304 – 1335Polar residuesSequence analysisAdd BLAST32

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM131 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3620, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063614

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A2VDJ0

Identification of Orthologs from Complete Genome Data

More...OMAi		NMNYHNG

Database of Orthologous Groups

More...OrthoDBi		45814at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A2VDJ0

TreeFam database of animal gene trees

More...TreeFami		TF321435

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039877, TMEM131-like
IPR022113, TMEM131-like_dom

The PANTHER Classification System

More...PANTHERi		PTHR22050, PTHR22050, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12371, TMEM131_like, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2VDJ0-1) [UniParc]FASTAAdd to basket
Also known as: L1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGLRRPQPG CYCRTAAAVN LLLGVFQVLL PCCRPGGAQG QAIEPLPNVV 
        60         70         80         90        100
ELWQAEEGEL LLPTQGDSEE GLEEPSQEQS FSDKLFSGKG LHFQPSVLDF 
       110        120        130        140        150
GIQFLGHPVA KILHAYNPSR DSEVVVNSVF AAAGHFHVPP VPCRVIPAMG 
       160        170        180        190        200
KTSFRIIFLP TEEGSIESSL FINTSSYGVL SYHVSGIGTR RISTEGSAKQ 
       210        220        230        240        250
LPNAYFLLPK VQSIQLSQMQ AETTNTSLLQ VQLECSLHNK VCQQLKGCYL 
       260        270        280        290        300
ESDDVLRLQM SIMVTMENFS KEFEENTQHL LDHLSIVYVA TDESETSDDS 
       310        320        330        340        350
AVNMYILHSG NSLIWIQDIR HFSQRDALSL QFEPVLLPTS TTNFTKIASF 
       360        370        380        390        400
TCKATSCDSG IIEDVKKTTH TPTLKACLFS SVAQGYFRMD SSATQFHIET 
       410        420        430        440        450
HENTSGLWSI WYRNHFDRSV VLNDVFLSKE TKHMLKILNF TGPLFLPPGC 
       460        470        480        490        500
WNIFSLKLAV KDIAINLFTN VFLTTNIGAI FAIPLQIYSA PTKEGSLGFE 
       510        520        530        540        550
VIAHCGMHYF MGKSKAGNPN WNGSLSLDQS TWNVDSELAN KLYERWKKYK 
       560        570        580        590        600
NGDVCKRNVL GTTRFAHLKK SKESESFVFF LPRLIAEPGL MLNFSATALR 
       610        620        630        640        650
SRMIKYFVVQ NPSSWPVSLQ LLPLSLYPKP EALVHLLHRW FGTDMQMINF 
       660        670        680        690        700
TTGEFQLTEA CPYLGTHSEE SRFGILHLHL QPLEMKRVGV VFTPADYGKV 
       710        720        730        740        750
TSLILIRNNL TVIDMIGVEG FGARELLKVG GRLPGAGGSL RFKVPESTLM 
       760        770        780        790        800
DCRRQLKDSK QILSITKNFK VENIGPLPIT VSSLKINGYN CQGYGFEVLD 
       810        820        830        840        850
CHQFSLDPNT SRDISIVFTP DFTSSWVIRD LSLVTAADLE FRFTLNVTLP 
       860        870        880        890        900
HHLLPLCADV VPGPSWEESF WRLTVFFVSL SLLGVILIAF QQAQYILMEF 
       910        920        930        940        950
MKTRQRQNAS SSSQQNNGPM DVISPHSYKS NCKNFLDTYG PSDKGRGKNC 
       960        970        980        990       1000
LPVNTPQSRI QNAAKRSPAT YGHSQKKHKC SVYYSKHKTS TAAASSTSTT 
      1010       1020       1030       1040       1050
TEEKQTSPLG SSLPAAKEDI CTDAMRENWI SLRYASGINV NLQKNLTLPK 
      1060       1070       1080       1090       1100
NLLNKEENTL KNTIVFSNPS SECSMKEGIQ TCMFPKETDI KTSENTAEFK 
      1110       1120       1130       1140       1150
ERELCPLKTS KKLPENHLPR NSPQYHQPDL PEISRKNNGN NQQVPVKNEV 
      1160       1170       1180       1190       1200
DHCENLKKVD TKPSSEKKIH KTSREDMFSE KQDIPFVEQE DPYRKKKLQE 
      1210       1220       1230       1240       1250
KREGNLQNLN WSKSRTCRKN KKRGVAPVSR PPEQSDLKLV CSDFERSELS 
      1260       1270       1280       1290       1300
SDINVRSWCI QESTREVCKA DAEIASSLPA AQREAEGYYQ KPEKKCVDKF 
      1310       1320       1330       1340       1350
CSDSSSDCGS SSGSVRASRG SWGSWSSTSS SDGDKKPMVD AQHFLPAGDS 
      1360       1370       1380       1390       1400
VSQNDFPSEA PISLNLSHNI CNPMTVNSLP QYAEPSCPSL PAGPTGVEED 
      1410       1420       1430       1440       1450
KGLYSPGDLW PTPPVCVTSS LNCTLENGVP CVIQESAPVH NSFIDWSATC 
      1460       1470       1480       1490       1500
EGQFSSAYCP LELNDYNAFP EENMNYANGF PCPADVQTDF IDHNSQSTWN 
      1510       1520       1530       1540       1550
TPPNMPAAWG HASFISSPPY LTSTRSLSPM SGLFGSIWAP QSDVYENCCP 
      1560       1570       1580       1590       1600
INPTTEHSTH MENQAVVCKE YYPGFNPFRA YMNLDIWTTT ANRNANFPLS 

RDSSYCGNV
Length:1,609
Mass (Da):179,339
Last modified:April 8, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F9D2EC0BC959210
GO
Isoform 2 (identifier: A2VDJ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-370: Missing.
     371-380: TPTLKACLFS → MLLVLECVLF

Show »
Length:1,239
Mass (Da):138,688
Checksum:iCB9238E5A0D84146
GO
Isoform 3 (identifier: A2VDJ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     353-353: K → KA
     557-640: Missing.

Show »
Length:1,526
Mass (Da):169,707
Checksum:i31C5F68FD8A4EBA5
GO
Isoform 4 (identifier: A2VDJ0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     353-353: K → KA

Show »
Length:1,610
Mass (Da):179,410
Checksum:i5D46F0BE83EB56CE
GO
Isoform 5 (identifier: A2VDJ0-6) [UniParc]FASTAAdd to basket
Also known as: S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-148: Missing.
     353-353: K → KA

Show »
Length:1,462
Mass (Da):163,518
Checksum:iA83EFE7797FC2590
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y2M0H0Y2M0_HUMAN
Transmembrane protein 131-like
TMEM131L
1,387Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEQ2F8WEQ2_HUMAN
Transmembrane protein 131-like
TMEM131L
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti171F → S in BAG52515 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042551604I → V. Corresponds to variant dbSNP:rs7669418Ensembl.1
Natural variantiVAR_042552645M → T1 PublicationCorresponds to variant dbSNP:rs17370297Ensembl.1
Natural variantiVAR_0425531110S → Y. Corresponds to variant dbSNP:rs755078Ensembl.1
Natural variantiVAR_0425541254N → S. Corresponds to variant dbSNP:rs35018723Ensembl.1
Natural variantiVAR_0425551392A → P. Corresponds to variant dbSNP:rs35543386Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0328261 – 370Missing in isoform 2. 1 PublicationAdd BLAST370
Alternative sequenceiVSP_0576331 – 148Missing in isoform 5. Add BLAST148
Alternative sequenceiVSP_032827353K → KA in isoform 3, isoform 4 and isoform 5. 3 Publications1
Alternative sequenceiVSP_032828371 – 380TPTLKACLFS → MLLVLECVLF in isoform 2. 1 Publication10
Alternative sequenceiVSP_032829557 – 640Missing in isoform 3. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL136932 mRNA Translation: CAB66866.1
AC106865 Genomic DNA No translation available.
AC116648 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04957.1
CH471056 Genomic DNA Translation: EAX04958.1
AK092270 mRNA Translation: BAG52515.1
BC044932 mRNA Translation: AAH44932.1
BC131505 mRNA Translation: AAI31506.1
AB023139 mRNA Translation: BAA76766.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3783.2 [A2VDJ0-1]
CCDS47148.1 [A2VDJ0-5]

NCBI Reference Sequences

More...RefSeqi		NP_001124479.1, NM_001131007.1 [A2VDJ0-5]
NP_056011.3, NM_015196.3 [A2VDJ0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000409663; ENSP00000386574; ENSG00000121210 [A2VDJ0-1]
ENST00000409959; ENSP00000386787; ENSG00000121210 [A2VDJ0-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23240

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23240

UCSC genome browser

More...UCSCi		uc003inm.5, human [A2VDJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136932 mRNA Translation: CAB66866.1
AC106865 Genomic DNA No translation available.
AC116648 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04957.1
CH471056 Genomic DNA Translation: EAX04958.1
AK092270 mRNA Translation: BAG52515.1
BC044932 mRNA Translation: AAH44932.1
BC131505 mRNA Translation: AAI31506.1
AB023139 mRNA Translation: BAA76766.1
CCDSiCCDS3783.2 [A2VDJ0-1]
CCDS47148.1 [A2VDJ0-5]
RefSeqiNP_001124479.1, NM_001131007.1 [A2VDJ0-5]
NP_056011.3, NM_015196.3 [A2VDJ0-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi116844, 47 interactors
IntActiA2VDJ0, 4 interactors
STRINGi9606.ENSP00000386787

PTM databases

GlyGeniA2VDJ0, 10 sites
iPTMnetiA2VDJ0
PhosphoSitePlusiA2VDJ0
SwissPalmiA2VDJ0

Genetic variation databases

BioMutaiTMEM131L

Proteomic databases

EPDiA2VDJ0
jPOSTiA2VDJ0
MassIVEiA2VDJ0
MaxQBiA2VDJ0
PaxDbiA2VDJ0
PeptideAtlasiA2VDJ0
PRIDEiA2VDJ0
ProteomicsDBi541 [A2VDJ0-1]
542 [A2VDJ0-2]
543 [A2VDJ0-3]
544 [A2VDJ0-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		57011, 55 antibodies

The DNASU plasmid repository

More...DNASUi		23240

Genome annotation databases

EnsembliENST00000409663; ENSP00000386574; ENSG00000121210 [A2VDJ0-1]
ENST00000409959; ENSP00000386787; ENSG00000121210 [A2VDJ0-5]
GeneIDi23240
KEGGihsa:23240
UCSCiuc003inm.5, human [A2VDJ0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23240
DisGeNETi23240

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMEM131L
HGNCiHGNC:29146, TMEM131L
HPAiENSG00000121210, Tissue enhanced (lymphoid)
MIMi616243, gene
neXtProtiNX_A2VDJ0
OpenTargetsiENSG00000121210
PharmGKBiPA128394615
VEuPathDBiHostDB:ENSG00000121210.15

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3620, Eukaryota
GeneTreeiENSGT00530000063614
InParanoidiA2VDJ0
OMAiNMNYHNG
OrthoDBi45814at2759
PhylomeDBiA2VDJ0
TreeFamiTF321435

Enzyme and pathway databases

PathwayCommonsiA2VDJ0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23240, 8 hits in 1012 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KIAA0922, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KIAA0922

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23240
PharosiA2VDJ0, Tbio

Protein Ontology

More...PROi		PR:A2VDJ0
RNActiA2VDJ0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000121210, Expressed in secondary oocyte and 206 other tissues
ExpressionAtlasiA2VDJ0, baseline and differential
GenevisibleiA2VDJ0, HS

Family and domain databases

InterProiView protein in InterPro
IPR039877, TMEM131-like
IPR022113, TMEM131-like_dom
PANTHERiPTHR22050, PTHR22050, 1 hit
PfamiView protein in Pfam
PF12371, TMEM131_like, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT131L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2VDJ0
Secondary accession number(s): B3KRV3
, D3DP10, Q7LGA7, Q86Y92, Q8WU56, Q9H065, Q9Y2D7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 2, 2021
This is version 113 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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