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UniProtKB - A2VDJ0 (T131L_HUMAN)

Protein

Transmembrane protein 131-like

Gene

TMEM131L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.1 Publication

GO - Biological processi

  • negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  • negative regulation of immature T cell proliferation in thymus Source: UniProtKB
  • Wnt signaling pathway Source: UniProtKB-KW
View the complete GO annotation on QuickGO ...

Keywordsi

Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 131-likeImported
Gene namesi
Name:TMEM131LImported
Synonyms:KIAA0922Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000121210.15
HGNCiHGNC:29146 TMEM131L
MIMi616243 gene
neXtProtiNX_A2VDJ0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini41 – 869ExtracellularSequence analysisAdd BLAST829
Transmembranei870 – 890HelicalSequence analysisAdd BLAST21
Topological domaini891 – 1609CytoplasmicSequence analysisAdd BLAST719

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121210
PharmGKBiPA128394615

Polymorphism and mutation databases

BioMutaiKIAA0922

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 40Sequence analysisAdd BLAST40
ChainiPRO_000032886541 – 1609Transmembrane protein 131-likeAdd BLAST1569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi522N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi593N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi709N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi846N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1122PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiA2VDJ0
MaxQBiA2VDJ0
PaxDbiA2VDJ0
PRIDEiA2VDJ0
ProteomicsDBi541
542 [A2VDJ0-2]
543 [A2VDJ0-3]
544 [A2VDJ0-5]

PTM databases

iPTMnetiA2VDJ0
PhosphoSitePlusiA2VDJ0
SwissPalmiA2VDJ0

Expressioni

Tissue specificityi

Expressed in thymocytes.1 Publication

Developmental stagei

During intrathymic development, transcript levels strongly increase from pro-DN1 thymocytes to DN3a cells, in which they peak, and drop immediately after beta-selection in their DN3b successors. The subcellular location of the protein also varies, from punctate cytoplasmic structures in DN1 and DN2 cells to large crescent-shaped membrane structures in DN3 cells, which preferentially localize in cell-to-cell contact zones.1 Publication

Gene expression databases

BgeeiENSG00000121210 Expressed in 188 organ(s), highest expression level in secondary oocyte
CleanExiHS_KIAA0922
ExpressionAtlasiA2VDJ0 baseline and differential
GenevisibleiA2VDJ0 HS

Organism-specific databases

HPAiHPA043472
HPA048443

Interactioni

Protein-protein interaction databases

BioGridi116844, 30 interactors
IntActiA2VDJ0, 1 interactor
STRINGi9606.ENSP00000386787

Structurei

3D structure databases

ProteinModelPortaliA2VDJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni696 – 916Required for Wnt-signaling inhibition and LRP6 degradation1 PublicationAdd BLAST221

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi910 – 913Poly-Ser4
Compositional biasi1302 – 1331Ser-richAdd BLAST30

Sequence similaritiesi

Belongs to the TMEM131 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3620 Eukaryota
ENOG410Z7NH LUCA
GeneTreeiENSGT00530000063614
HOGENOMiHOG000154480
HOVERGENiHBG108533
InParanoidiA2VDJ0
OMAiCQGYGFE
OrthoDBiEOG091G0HKE
PhylomeDBiA2VDJ0
TreeFamiTF321435

Family and domain databases

InterProiView protein in InterPro
IPR022113 TMEM131-like
PfamiView protein in Pfam
PF12371 TMEM131_like, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2VDJ0-1) [UniParc]FASTAAdd to basket
Also known as: L1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGLRRPQPG CYCRTAAAVN LLLGVFQVLL PCCRPGGAQG QAIEPLPNVV 
        60         70         80         90        100
ELWQAEEGEL LLPTQGDSEE GLEEPSQEQS FSDKLFSGKG LHFQPSVLDF 
       110        120        130        140        150
GIQFLGHPVA KILHAYNPSR DSEVVVNSVF AAAGHFHVPP VPCRVIPAMG 
       160        170        180        190        200
KTSFRIIFLP TEEGSIESSL FINTSSYGVL SYHVSGIGTR RISTEGSAKQ 
       210        220        230        240        250
LPNAYFLLPK VQSIQLSQMQ AETTNTSLLQ VQLECSLHNK VCQQLKGCYL 
       260        270        280        290        300
ESDDVLRLQM SIMVTMENFS KEFEENTQHL LDHLSIVYVA TDESETSDDS 
       310        320        330        340        350
AVNMYILHSG NSLIWIQDIR HFSQRDALSL QFEPVLLPTS TTNFTKIASF 
       360        370        380        390        400
TCKATSCDSG IIEDVKKTTH TPTLKACLFS SVAQGYFRMD SSATQFHIET 
       410        420        430        440        450
HENTSGLWSI WYRNHFDRSV VLNDVFLSKE TKHMLKILNF TGPLFLPPGC 
       460        470        480        490        500
WNIFSLKLAV KDIAINLFTN VFLTTNIGAI FAIPLQIYSA PTKEGSLGFE 
       510        520        530        540        550
VIAHCGMHYF MGKSKAGNPN WNGSLSLDQS TWNVDSELAN KLYERWKKYK 
       560        570        580        590        600
NGDVCKRNVL GTTRFAHLKK SKESESFVFF LPRLIAEPGL MLNFSATALR 
       610        620        630        640        650
SRMIKYFVVQ NPSSWPVSLQ LLPLSLYPKP EALVHLLHRW FGTDMQMINF 
       660        670        680        690        700
TTGEFQLTEA CPYLGTHSEE SRFGILHLHL QPLEMKRVGV VFTPADYGKV 
       710        720        730        740        750
TSLILIRNNL TVIDMIGVEG FGARELLKVG GRLPGAGGSL RFKVPESTLM 
       760        770        780        790        800
DCRRQLKDSK QILSITKNFK VENIGPLPIT VSSLKINGYN CQGYGFEVLD 
       810        820        830        840        850
CHQFSLDPNT SRDISIVFTP DFTSSWVIRD LSLVTAADLE FRFTLNVTLP 
       860        870        880        890        900
HHLLPLCADV VPGPSWEESF WRLTVFFVSL SLLGVILIAF QQAQYILMEF 
       910        920        930        940        950
MKTRQRQNAS SSSQQNNGPM DVISPHSYKS NCKNFLDTYG PSDKGRGKNC 
       960        970        980        990       1000
LPVNTPQSRI QNAAKRSPAT YGHSQKKHKC SVYYSKHKTS TAAASSTSTT 
      1010       1020       1030       1040       1050
TEEKQTSPLG SSLPAAKEDI CTDAMRENWI SLRYASGINV NLQKNLTLPK 
      1060       1070       1080       1090       1100
NLLNKEENTL KNTIVFSNPS SECSMKEGIQ TCMFPKETDI KTSENTAEFK 
      1110       1120       1130       1140       1150
ERELCPLKTS KKLPENHLPR NSPQYHQPDL PEISRKNNGN NQQVPVKNEV 
      1160       1170       1180       1190       1200
DHCENLKKVD TKPSSEKKIH KTSREDMFSE KQDIPFVEQE DPYRKKKLQE 
      1210       1220       1230       1240       1250
KREGNLQNLN WSKSRTCRKN KKRGVAPVSR PPEQSDLKLV CSDFERSELS 
      1260       1270       1280       1290       1300
SDINVRSWCI QESTREVCKA DAEIASSLPA AQREAEGYYQ KPEKKCVDKF 
      1310       1320       1330       1340       1350
CSDSSSDCGS SSGSVRASRG SWGSWSSTSS SDGDKKPMVD AQHFLPAGDS 
      1360       1370       1380       1390       1400
VSQNDFPSEA PISLNLSHNI CNPMTVNSLP QYAEPSCPSL PAGPTGVEED 
      1410       1420       1430       1440       1450
KGLYSPGDLW PTPPVCVTSS LNCTLENGVP CVIQESAPVH NSFIDWSATC 
      1460       1470       1480       1490       1500
EGQFSSAYCP LELNDYNAFP EENMNYANGF PCPADVQTDF IDHNSQSTWN 
      1510       1520       1530       1540       1550
TPPNMPAAWG HASFISSPPY LTSTRSLSPM SGLFGSIWAP QSDVYENCCP 
      1560       1570       1580       1590       1600
INPTTEHSTH MENQAVVCKE YYPGFNPFRA YMNLDIWTTT ANRNANFPLS 

RDSSYCGNV
Length:1,609
Mass (Da):179,339
Last modified:April 8, 2008 - v2
Checksum:i7F9D2EC0BC959210
GO
Isoform 2 (identifier: A2VDJ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-370: Missing.
     371-380: TPTLKACLFS → MLLVLECVLF

Note: No experimental confirmation available.
Show »
Length:1,239
Mass (Da):138,688
Checksum:iCB9238E5A0D84146
GO
Isoform 3 (identifier: A2VDJ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     353-353: K → KA
     557-640: Missing.

Note: No experimental confirmation available.
Show »
Length:1,526
Mass (Da):169,707
Checksum:i31C5F68FD8A4EBA5
GO
Isoform 4 (identifier: A2VDJ0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     353-353: K → KA

Note: No experimental confirmation available.
Show »
Length:1,610
Mass (Da):179,410
Checksum:i5D46F0BE83EB56CE
GO
Isoform 5 (identifier: A2VDJ0-6) [UniParc]FASTAAdd to basket
Also known as: S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-148: Missing.
     353-353: K → KA

Note: No experimental confirmation available.
Show »
Length:1,462
Mass (Da):163,518
Checksum:iA83EFE7797FC2590
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WEQ2F8WEQ2_HUMAN
Transmembrane protein 131-like
TMEM131L
71Annotation score:
H0Y2M0H0Y2M0_HUMAN
Transmembrane protein 131-like
TMEM131L
1,387Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171F → S in BAG52515 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042551604I → V. Corresponds to variant dbSNP:rs7669418Ensembl.1
Natural variantiVAR_042552645M → T1 PublicationCorresponds to variant dbSNP:rs17370297Ensembl.1
Natural variantiVAR_0425531110S → Y. Corresponds to variant dbSNP:rs755078Ensembl.1
Natural variantiVAR_0425541254N → S. Corresponds to variant dbSNP:rs35018723Ensembl.1
Natural variantiVAR_0425551392A → P. Corresponds to variant dbSNP:rs35543386Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0328261 – 370Missing in isoform 2. 1 PublicationAdd BLAST370
Alternative sequenceiVSP_0576331 – 148Missing in isoform 5. Add BLAST148
Alternative sequenceiVSP_032827353K → KA in isoform 3, isoform 4 and isoform 5. 3 Publications1
Alternative sequenceiVSP_032828371 – 380TPTLKACLFS → MLLVLECVLF in isoform 2. 1 Publication10
Alternative sequenceiVSP_032829557 – 640Missing in isoform 3. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136932 mRNA Translation: CAB66866.1
AC106865 Genomic DNA No translation available.
AC116648 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04957.1
CH471056 Genomic DNA Translation: EAX04958.1
AK092270 mRNA Translation: BAG52515.1
BC044932 mRNA Translation: AAH44932.1
BC131505 mRNA Translation: AAI31506.1
AB023139 mRNA Translation: BAA76766.1
CCDSiCCDS3783.2 [A2VDJ0-1]
CCDS47148.1 [A2VDJ0-5]
RefSeqiNP_001124479.1, NM_001131007.1 [A2VDJ0-5]
NP_056011.3, NM_015196.3 [A2VDJ0-1]
UniGeneiHs.732450

Genome annotation databases

EnsembliENST00000409663; ENSP00000386574; ENSG00000121210 [A2VDJ0-1]
ENST00000409959; ENSP00000386787; ENSG00000121210 [A2VDJ0-5]
GeneIDi23240
KEGGihsa:23240
UCSCiuc003inm.5 human [A2VDJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136932 mRNA Translation: CAB66866.1
AC106865 Genomic DNA No translation available.
AC116648 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04957.1
CH471056 Genomic DNA Translation: EAX04958.1
AK092270 mRNA Translation: BAG52515.1
BC044932 mRNA Translation: AAH44932.1
BC131505 mRNA Translation: AAI31506.1
AB023139 mRNA Translation: BAA76766.1
CCDSiCCDS3783.2 [A2VDJ0-1]
CCDS47148.1 [A2VDJ0-5]
RefSeqiNP_001124479.1, NM_001131007.1 [A2VDJ0-5]
NP_056011.3, NM_015196.3 [A2VDJ0-1]
UniGeneiHs.732450

3D structure databases

ProteinModelPortaliA2VDJ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116844, 30 interactors
IntActiA2VDJ0, 1 interactor
STRINGi9606.ENSP00000386787

PTM databases

iPTMnetiA2VDJ0
PhosphoSitePlusiA2VDJ0
SwissPalmiA2VDJ0

Polymorphism and mutation databases

BioMutaiKIAA0922

Proteomic databases

EPDiA2VDJ0
MaxQBiA2VDJ0
PaxDbiA2VDJ0
PRIDEiA2VDJ0
ProteomicsDBi541
542 [A2VDJ0-2]
543 [A2VDJ0-3]
544 [A2VDJ0-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409663; ENSP00000386574; ENSG00000121210 [A2VDJ0-1]
ENST00000409959; ENSP00000386787; ENSG00000121210 [A2VDJ0-5]
GeneIDi23240
KEGGihsa:23240
UCSCiuc003inm.5 human [A2VDJ0-1]

Organism-specific databases

CTDi23240
EuPathDBiHostDB:ENSG00000121210.15
GeneCardsiTMEM131L
H-InvDBiHIX0004579
HGNCiHGNC:29146 TMEM131L
HPAiHPA043472
HPA048443
MIMi616243 gene
neXtProtiNX_A2VDJ0
OpenTargetsiENSG00000121210
PharmGKBiPA128394615
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3620 Eukaryota
ENOG410Z7NH LUCA
GeneTreeiENSGT00530000063614
HOGENOMiHOG000154480
HOVERGENiHBG108533
InParanoidiA2VDJ0
OMAiCQGYGFE
OrthoDBiEOG091G0HKE
PhylomeDBiA2VDJ0
TreeFamiTF321435

Miscellaneous databases

ChiTaRSiKIAA0922 human
GeneWikiiKIAA0922
GenomeRNAii23240
PROiPR:A2VDJ0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121210 Expressed in 188 organ(s), highest expression level in secondary oocyte
CleanExiHS_KIAA0922
ExpressionAtlasiA2VDJ0 baseline and differential
GenevisibleiA2VDJ0 HS

Family and domain databases

InterProiView protein in InterPro
IPR022113 TMEM131-like
PfamiView protein in Pfam
PF12371 TMEM131_like, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT131L_HUMAN
AccessioniPrimary (citable) accession number: A2VDJ0
Secondary accession number(s): B3KRV3
, D3DP10, Q7LGA7, Q86Y92, Q8WU56, Q9H065, Q9Y2D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: October 10, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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