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Protein

Transmembrane protein 131-like

Gene

TMEM131L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  • negative regulation of immature T cell proliferation in thymus Source: UniProtKB
  • Wnt signaling pathway Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 131-likeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM131LImported
Synonyms:KIAA0922Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000121210.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29146 TMEM131L

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616243 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A2VDJ0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini41 – 869ExtracellularSequence analysisAdd BLAST829
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei870 – 890HelicalSequence analysisAdd BLAST21
Topological domaini891 – 1609CytoplasmicSequence analysisAdd BLAST719

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000121210

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394615

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM131L

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 40Sequence analysisAdd BLAST40
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032886541 – 1609Transmembrane protein 131-likeAdd BLAST1569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi522N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi593N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi709N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi846N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1122PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2VDJ0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2VDJ0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2VDJ0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2VDJ0

PRoteomics IDEntifications database

More...
PRIDEi
A2VDJ0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
541
542 [A2VDJ0-2]
543 [A2VDJ0-3]
544 [A2VDJ0-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2VDJ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2VDJ0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
A2VDJ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in thymocytes.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

During intrathymic development, transcript levels strongly increase from pro-DN1 thymocytes to DN3a cells, in which they peak, and drop immediately after beta-selection in their DN3b successors. The subcellular location of the protein also varies, from punctate cytoplasmic structures in DN1 and DN2 cells to large crescent-shaped membrane structures in DN3 cells, which preferentially localize in cell-to-cell contact zones.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000121210 Expressed in 188 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_KIAA0922

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2VDJ0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2VDJ0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043472
HPA048443

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116844, 30 interactors

Protein interaction database and analysis system

More...
IntActi
A2VDJ0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386787

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2VDJ0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni696 – 916Required for Wnt-signaling inhibition and LRP6 degradation1 PublicationAdd BLAST221

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi910 – 913Poly-Ser4
Compositional biasi1302 – 1331Ser-richAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM131 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3620 Eukaryota
ENOG410Z7NH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063614

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154480

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108533

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2VDJ0

Identification of Orthologs from Complete Genome Data

More...
OMAi
SESFVFF

Database of Orthologous Groups

More...
OrthoDBi
826997at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2VDJ0

TreeFam database of animal gene trees

More...
TreeFami
TF321435

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039877 TMEM131-like
IPR022113 TMEM131-like_dom

The PANTHER Classification System

More...
PANTHERi
PTHR22050 PTHR22050, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12371 TMEM131_like, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2VDJ0-1) [UniParc]FASTAAdd to basket
Also known as: L1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGLRRPQPG CYCRTAAAVN LLLGVFQVLL PCCRPGGAQG QAIEPLPNVV
60 70 80 90 100
ELWQAEEGEL LLPTQGDSEE GLEEPSQEQS FSDKLFSGKG LHFQPSVLDF
110 120 130 140 150
GIQFLGHPVA KILHAYNPSR DSEVVVNSVF AAAGHFHVPP VPCRVIPAMG
160 170 180 190 200
KTSFRIIFLP TEEGSIESSL FINTSSYGVL SYHVSGIGTR RISTEGSAKQ
210 220 230 240 250
LPNAYFLLPK VQSIQLSQMQ AETTNTSLLQ VQLECSLHNK VCQQLKGCYL
260 270 280 290 300
ESDDVLRLQM SIMVTMENFS KEFEENTQHL LDHLSIVYVA TDESETSDDS
310 320 330 340 350
AVNMYILHSG NSLIWIQDIR HFSQRDALSL QFEPVLLPTS TTNFTKIASF
360 370 380 390 400
TCKATSCDSG IIEDVKKTTH TPTLKACLFS SVAQGYFRMD SSATQFHIET
410 420 430 440 450
HENTSGLWSI WYRNHFDRSV VLNDVFLSKE TKHMLKILNF TGPLFLPPGC
460 470 480 490 500
WNIFSLKLAV KDIAINLFTN VFLTTNIGAI FAIPLQIYSA PTKEGSLGFE
510 520 530 540 550
VIAHCGMHYF MGKSKAGNPN WNGSLSLDQS TWNVDSELAN KLYERWKKYK
560 570 580 590 600
NGDVCKRNVL GTTRFAHLKK SKESESFVFF LPRLIAEPGL MLNFSATALR
610 620 630 640 650
SRMIKYFVVQ NPSSWPVSLQ LLPLSLYPKP EALVHLLHRW FGTDMQMINF
660 670 680 690 700
TTGEFQLTEA CPYLGTHSEE SRFGILHLHL QPLEMKRVGV VFTPADYGKV
710 720 730 740 750
TSLILIRNNL TVIDMIGVEG FGARELLKVG GRLPGAGGSL RFKVPESTLM
760 770 780 790 800
DCRRQLKDSK QILSITKNFK VENIGPLPIT VSSLKINGYN CQGYGFEVLD
810 820 830 840 850
CHQFSLDPNT SRDISIVFTP DFTSSWVIRD LSLVTAADLE FRFTLNVTLP
860 870 880 890 900
HHLLPLCADV VPGPSWEESF WRLTVFFVSL SLLGVILIAF QQAQYILMEF
910 920 930 940 950
MKTRQRQNAS SSSQQNNGPM DVISPHSYKS NCKNFLDTYG PSDKGRGKNC
960 970 980 990 1000
LPVNTPQSRI QNAAKRSPAT YGHSQKKHKC SVYYSKHKTS TAAASSTSTT
1010 1020 1030 1040 1050
TEEKQTSPLG SSLPAAKEDI CTDAMRENWI SLRYASGINV NLQKNLTLPK
1060 1070 1080 1090 1100
NLLNKEENTL KNTIVFSNPS SECSMKEGIQ TCMFPKETDI KTSENTAEFK
1110 1120 1130 1140 1150
ERELCPLKTS KKLPENHLPR NSPQYHQPDL PEISRKNNGN NQQVPVKNEV
1160 1170 1180 1190 1200
DHCENLKKVD TKPSSEKKIH KTSREDMFSE KQDIPFVEQE DPYRKKKLQE
1210 1220 1230 1240 1250
KREGNLQNLN WSKSRTCRKN KKRGVAPVSR PPEQSDLKLV CSDFERSELS
1260 1270 1280 1290 1300
SDINVRSWCI QESTREVCKA DAEIASSLPA AQREAEGYYQ KPEKKCVDKF
1310 1320 1330 1340 1350
CSDSSSDCGS SSGSVRASRG SWGSWSSTSS SDGDKKPMVD AQHFLPAGDS
1360 1370 1380 1390 1400
VSQNDFPSEA PISLNLSHNI CNPMTVNSLP QYAEPSCPSL PAGPTGVEED
1410 1420 1430 1440 1450
KGLYSPGDLW PTPPVCVTSS LNCTLENGVP CVIQESAPVH NSFIDWSATC
1460 1470 1480 1490 1500
EGQFSSAYCP LELNDYNAFP EENMNYANGF PCPADVQTDF IDHNSQSTWN
1510 1520 1530 1540 1550
TPPNMPAAWG HASFISSPPY LTSTRSLSPM SGLFGSIWAP QSDVYENCCP
1560 1570 1580 1590 1600
INPTTEHSTH MENQAVVCKE YYPGFNPFRA YMNLDIWTTT ANRNANFPLS

RDSSYCGNV
Length:1,609
Mass (Da):179,339
Last modified:April 8, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F9D2EC0BC959210
GO
Isoform 2 (identifier: A2VDJ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-370: Missing.
     371-380: TPTLKACLFS → MLLVLECVLF

Note: No experimental confirmation available.
Show »
Length:1,239
Mass (Da):138,688
Checksum:iCB9238E5A0D84146
GO
Isoform 3 (identifier: A2VDJ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     353-353: K → KA
     557-640: Missing.

Note: No experimental confirmation available.
Show »
Length:1,526
Mass (Da):169,707
Checksum:i31C5F68FD8A4EBA5
GO
Isoform 4 (identifier: A2VDJ0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     353-353: K → KA

Note: No experimental confirmation available.
Show »
Length:1,610
Mass (Da):179,410
Checksum:i5D46F0BE83EB56CE
GO
Isoform 5 (identifier: A2VDJ0-6) [UniParc]FASTAAdd to basket
Also known as: S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-148: Missing.
     353-353: K → KA

Note: No experimental confirmation available.
Show »
Length:1,462
Mass (Da):163,518
Checksum:iA83EFE7797FC2590
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WEQ2F8WEQ2_HUMAN
Transmembrane protein 131-like
TMEM131L
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y2M0H0Y2M0_HUMAN
Transmembrane protein 131-like
TMEM131L
1,387Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti171F → S in BAG52515 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042551604I → V. Corresponds to variant dbSNP:rs7669418Ensembl.1
Natural variantiVAR_042552645M → T1 PublicationCorresponds to variant dbSNP:rs17370297Ensembl.1
Natural variantiVAR_0425531110S → Y. Corresponds to variant dbSNP:rs755078Ensembl.1
Natural variantiVAR_0425541254N → S. Corresponds to variant dbSNP:rs35018723Ensembl.1
Natural variantiVAR_0425551392A → P. Corresponds to variant dbSNP:rs35543386Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0328261 – 370Missing in isoform 2. 1 PublicationAdd BLAST370
Alternative sequenceiVSP_0576331 – 148Missing in isoform 5. Add BLAST148
Alternative sequenceiVSP_032827353K → KA in isoform 3, isoform 4 and isoform 5. 3 Publications1
Alternative sequenceiVSP_032828371 – 380TPTLKACLFS → MLLVLECVLF in isoform 2. 1 Publication10
Alternative sequenceiVSP_032829557 – 640Missing in isoform 3. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL136932 mRNA Translation: CAB66866.1
AC106865 Genomic DNA No translation available.
AC116648 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04957.1
CH471056 Genomic DNA Translation: EAX04958.1
AK092270 mRNA Translation: BAG52515.1
BC044932 mRNA Translation: AAH44932.1
BC131505 mRNA Translation: AAI31506.1
AB023139 mRNA Translation: BAA76766.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3783.2 [A2VDJ0-1]
CCDS47148.1 [A2VDJ0-5]

NCBI Reference Sequences

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RefSeqi
NP_001124479.1, NM_001131007.1 [A2VDJ0-5]
NP_056011.3, NM_015196.3 [A2VDJ0-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.732450

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000409663; ENSP00000386574; ENSG00000121210 [A2VDJ0-1]
ENST00000409959; ENSP00000386787; ENSG00000121210 [A2VDJ0-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23240

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23240

UCSC genome browser

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UCSCi
uc003inm.5 human [A2VDJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136932 mRNA Translation: CAB66866.1
AC106865 Genomic DNA No translation available.
AC116648 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04957.1
CH471056 Genomic DNA Translation: EAX04958.1
AK092270 mRNA Translation: BAG52515.1
BC044932 mRNA Translation: AAH44932.1
BC131505 mRNA Translation: AAI31506.1
AB023139 mRNA Translation: BAA76766.1
CCDSiCCDS3783.2 [A2VDJ0-1]
CCDS47148.1 [A2VDJ0-5]
RefSeqiNP_001124479.1, NM_001131007.1 [A2VDJ0-5]
NP_056011.3, NM_015196.3 [A2VDJ0-1]
UniGeneiHs.732450

3D structure databases

ProteinModelPortaliA2VDJ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116844, 30 interactors
IntActiA2VDJ0, 1 interactor
STRINGi9606.ENSP00000386787

PTM databases

iPTMnetiA2VDJ0
PhosphoSitePlusiA2VDJ0
SwissPalmiA2VDJ0

Polymorphism and mutation databases

BioMutaiTMEM131L

Proteomic databases

EPDiA2VDJ0
jPOSTiA2VDJ0
MaxQBiA2VDJ0
PaxDbiA2VDJ0
PRIDEiA2VDJ0
ProteomicsDBi541
542 [A2VDJ0-2]
543 [A2VDJ0-3]
544 [A2VDJ0-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409663; ENSP00000386574; ENSG00000121210 [A2VDJ0-1]
ENST00000409959; ENSP00000386787; ENSG00000121210 [A2VDJ0-5]
GeneIDi23240
KEGGihsa:23240
UCSCiuc003inm.5 human [A2VDJ0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23240
EuPathDBiHostDB:ENSG00000121210.15

GeneCards: human genes, protein and diseases

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GeneCardsi
TMEM131L

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0004579
HGNCiHGNC:29146 TMEM131L
HPAiHPA043472
HPA048443
MIMi616243 gene
neXtProtiNX_A2VDJ0
OpenTargetsiENSG00000121210
PharmGKBiPA128394615

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3620 Eukaryota
ENOG410Z7NH LUCA
GeneTreeiENSGT00530000063614
HOGENOMiHOG000154480
HOVERGENiHBG108533
InParanoidiA2VDJ0
OMAiSESFVFF
OrthoDBi826997at2759
PhylomeDBiA2VDJ0
TreeFamiTF321435

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KIAA0922 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KIAA0922

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23240

Protein Ontology

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PROi
PR:A2VDJ0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000121210 Expressed in 188 organ(s), highest expression level in secondary oocyte
CleanExiHS_KIAA0922
ExpressionAtlasiA2VDJ0 baseline and differential
GenevisibleiA2VDJ0 HS

Family and domain databases

InterProiView protein in InterPro
IPR039877 TMEM131-like
IPR022113 TMEM131-like_dom
PANTHERiPTHR22050 PTHR22050, 1 hit
PfamiView protein in Pfam
PF12371 TMEM131_like, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT131L_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2VDJ0
Secondary accession number(s): B3KRV3
, D3DP10, Q7LGA7, Q86Y92, Q8WU56, Q9H065, Q9Y2D7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: January 16, 2019
This is version 97 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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