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Protein
Submitted name:

Apolipoprotein L 8

Gene

Apol8

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • lipid binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-2168880 Scavenging of heme from plasma
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Submitted name:
Apolipoprotein L 8Imported
Submitted name:
MCG13357Imported
Gene namesi
Name:Apol8Imported
ORF Names:mCG_13357Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2444921 Apol8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Transmembranei151 – 176HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

LipoproteinImported

Expressioni

Gene expression databases

BgeeiENSMUSG00000056656 Expressed in 77 organ(s), highest expression level in liver

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili302 – 336Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IWES Eukaryota
ENOG410Y0AF LUCA
GeneTreeiENSGT00510000046700
HOVERGENiHBG074468
KOiK14480
OMAiQEWDFEK
OrthoDBiEOG091G0KT4
TreeFamiTF334681

Family and domain databases

InterProiView protein in InterPro
IPR008405 ApoL
PANTHERiPTHR14096 PTHR14096, 1 hit
PfamiView protein in Pfam
PF05461 ApoL, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2VDH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPSDCEDAP GDRTFIEEAA EYLQHTSGRE DLRLLLTEDG AWEAFVAEAE
60 70 80 90 100
LSRADADTLR DALHALTANL AVEDQERLQR DLQDMERFMD AFPQVKLELE
110 120 130 140 150
GHIGKLRTLA DKVDKVHRDC TISKLVAGST STVSGILTLL GLTLVPVTAG
160 170 180 190 200
ISLVLLATGM GLGAAAAVTS VSSGIVDYTS RSLAKTEASH LVSTGMAKVK
210 220 230 240 250
MVADAVVHSG PQVLSLSENC CRVLRCIEQS IYAIKLTKAN PALAASAMGS
260 270 280 290 300
TSAQSGKHVK KAFKGTALAI SRRARIMGIA TAGVSLVGDV ISLVKQSKNL
310 320 330
HKGTKAKSAE ELRQQARELE EKLEALIQMY EGLQAGSRR
Length:339
Mass (Da):36,196
Last modified:March 20, 2007 - v1
Checksum:i3DF4A3B7E443F949
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VHH5A0A2R8VHH5_MOUSE
Apolipoprotein L 8
Apol8
78Annotation score:
A0A2R8VHV6A0A2R8VHV6_MOUSE
Apolipoprotein L 8
Apol8
25Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583886 Genomic DNA No translation available.
BC129972 mRNA Translation: AAI29973.1
CH466545 Genomic DNA Translation: EDL29649.1
RefSeqiNP_001075439.1, NM_001081970.1
XP_006520997.2, XM_006520934.3
XP_006521003.1, XM_006520940.3
XP_006521004.1, XM_006520941.3
UniGeneiMm.125650

Genome annotation databases

EnsembliENSMUST00000070911; ENSMUSP00000064237; ENSMUSG00000056656
ENSMUST00000089450; ENSMUSP00000086873; ENSMUSG00000056656
GeneIDi239552
KEGGimmu:239552
UCSCiuc007woa.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583886 Genomic DNA No translation available.
BC129972 mRNA Translation: AAI29973.1
CH466545 Genomic DNA Translation: EDL29649.1
RefSeqiNP_001075439.1, NM_001081970.1
XP_006520997.2, XM_006520934.3
XP_006521003.1, XM_006520940.3
XP_006521004.1, XM_006520941.3
UniGeneiMm.125650

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070911; ENSMUSP00000064237; ENSMUSG00000056656
ENSMUST00000089450; ENSMUSP00000086873; ENSMUSG00000056656
GeneIDi239552
KEGGimmu:239552
UCSCiuc007woa.2 mouse

Organism-specific databases

CTDi239552
MGIiMGI:2444921 Apol8

Phylogenomic databases

eggNOGiENOG410IWES Eukaryota
ENOG410Y0AF LUCA
GeneTreeiENSGT00510000046700
HOVERGENiHBG074468
KOiK14480
OMAiQEWDFEK
OrthoDBiEOG091G0KT4
TreeFamiTF334681

Enzyme and pathway databases

ReactomeiR-MMU-2168880 Scavenging of heme from plasma
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056656 Expressed in 77 organ(s), highest expression level in liver

Family and domain databases

InterProiView protein in InterPro
IPR008405 ApoL
PANTHERiPTHR14096 PTHR14096, 1 hit
PfamiView protein in Pfam
PF05461 ApoL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2VDH7_MOUSE
AccessioniPrimary (citable) accession number: A2VDH7
Secondary accession number(s): F6VS49, F7B5U4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 7, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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