Mlx

Functionⁱ

GO - Molecular functionⁱ

DNA-binding transcription factor activity Source: GO_Central
protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl
RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: Ensembl
transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of transcription by RNA polymerase II Source: Ensembl
regulation of transcription by RNA polymerase II Source: GO_Central

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: MAX-like protein XImported Submitted name: MAX-like protein X, isoform CRA_aImported Submitted name: MLX, MAX dimerization proteinImported
Gene namesⁱ	Name:MlxImported ORF Names:rCG_32676Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 10

Organism-specific databases

Rat genome database More...RGDⁱ	1308590 Mlx

RGDⁱ

1308590 Mlx

Subcellular locationⁱ

GO - Cellular component

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000019983 Expressed in 10 organ(s), highest expression level in colon

Bgeeⁱ

ENSRNOG00000019983 Expressed in 10 organ(s), highest expression level in colon

Interactionⁱ

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl
transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000027116

STRINGⁱ

10116.ENSRNOP00000027116

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	129 – 187	BHLHInterPro annotationAdd BLAST		59

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	123 – 143	Sequence analysisAdd BLAST		21
Coiled coilⁱ	184 – 211	Sequence analysisAdd BLAST		28

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG1319 Eukaryota ENOG410ZWIP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063219
HOGENOMⁱ	HOG000232118
HOVERGENⁱ	HBG019061
KEGG Orthology (KO) More...KOⁱ	K09113
OMAⁱ	IMEEMFE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RUK
TreeFamⁱ	TF318841

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032647 Mlx
PANTHERⁱ	PTHR15741:SF25 PTHR15741:SF25, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A2VCV8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTEPGASPED PWVKASSADA HAGEGRAGRA RARRGSGRRG APQLSPESPL 
        60         70         80         90        100
LSRPRGCRED SSHPACAKVE YAYSDNSLDP GLFVESTHKG SVVSRANSIG 
       110        120        130        140        150
STSASSVPNT DDEDSDYQQE SYKESYKDRR RRAHTQAEQK RRDAIKRGYD 
       160        170        180        190        200
DLQTIVPTCQ QQDFSIGSQK LSKAIVLQKT IDYIQFLHKE KKKQEEEVST 
       210        220        230        240        250
LRKDVTALKI MKVNYEQIVK AHQDNPHEGE DQVSDQVKFN VFQGIMDSLF 
       260        270        280        290 
QSFNASISVA SFQELSACVF SWIEEHCEPQ TLREIVIGVL HQLKNQLY

Length:298

Mass (Da):33,420

Last modified:March 20, 2007 - v1

Checksum:ⁱ7C2514E099694EBA

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07072184 Genomic DNA No translation available. BC128702 mRNA Translation: AAI28703.1 CH473948 Genomic DNA Translation: EDM06085.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001029284.1, NM_001034112.1
UniGeneⁱ	Rn.16914

Genome annotation databases

Ensemblⁱ	ENSRNOT00000027116; ENSRNOP00000027116; ENSRNOG00000019983
GeneIDⁱ	360631
KEGGⁱ	rno:360631

Protein	Similar proteins		Species	Score	Length	Source
A2VCV8	Max-like protein X		HUMAN		298	UniRef90_Q9UH92
Max-like protein X		MOUSE		298
MLX isoform 1		PANTR		298
Uncharacterized protein		PANPA		298
MLX, MAX dimerization protein		MACMU		298
+56

Protein	Similar proteins		Species	Score	Length	Source
A2VCV8	Max-like protein X		HUMAN		298	UniRef50_Q9UH92
Max-like protein X		MOUSE		298
MLX isoform 1		PANTR		298
Uncharacterized protein		PANPA		298
Uncharacterized protein		CALJA		298
+116

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07072184 Genomic DNA No translation available. BC128702 mRNA Translation: AAI28703.1 CH473948 Genomic DNA Translation: EDM06085.1
RefSeqⁱ	NP_001029284.1, NM_001034112.1
UniGeneⁱ	Rn.16914

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000027116

STRINGⁱ

10116.ENSRNOP00000027116

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000027116; ENSRNOP00000027116; ENSRNOG00000019983
GeneIDⁱ	360631
KEGGⁱ	rno:360631

Organism-specific databases

CTDⁱ	6945
RGDⁱ	1308590 Mlx

Phylogenomic databases

eggNOGⁱ	KOG1319 Eukaryota ENOG410ZWIP LUCA
GeneTreeⁱ	ENSGT00530000063219
HOGENOMⁱ	HOG000232118
HOVERGENⁱ	HBG019061
KOⁱ	K09113
OMAⁱ	IMEEMFE
OrthoDBⁱ	EOG091G0RUK
TreeFamⁱ	TF318841

Gene expression databases

Bgeeⁱ	ENSRNOG00000019983 Expressed in 10 organ(s), highest expression level in colon

Bgeeⁱ

ENSRNOG00000019983 Expressed in 10 organ(s), highest expression level in colon

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032647 Mlx
PANTHERⁱ	PTHR15741:SF25 PTHR15741:SF25, 1 hit
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A2VCV8_RAT
Accessionⁱ	A2VCV8Primary (citable) accession number: A2VCV8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 20, 2007
	Last sequence update:	March 20, 2007
	Last modified:	September 12, 2018
	This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A2VCV8 (A2VCV8_RAT)

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MAX-like protein X

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ