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UniProtKB - A2VCV8 (A2VCV8_RAT)
Protein
Submitted name:
MAX dimerization protein MLX
Gene
Mlx
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- protein heterodimerization activity Source: RGD
- protein homodimerization activity Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- nucleocytoplasmic transport Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Enzyme and pathway databases
Reactomei | R-RNO-163765, ChREBP activates metabolic gene expression |
Names & Taxonomyi
Protein namesi | Submitted name: MAX dimerization protein MLXImportedSubmitted name: MAX-like protein XImportedSubmitted name: MAX-like protein X, isoform CRA_aImported |
Gene namesi | Name:MlxImported ORF Names:rCG_32676Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1308590, Mlx |
Subcellular locationi
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000019983, Expressed in duodenum and 21 other tissues |
Interactioni
GO - Molecular functioni
- protein heterodimerization activity Source: RGD
- protein homodimerization activity Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000027116 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 129 – 187 | BHLHInterPro annotationAdd BLAST | 59 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 63 | DisorderedSequence analysisAdd BLAST | 63 | |
Regioni | 98 – 145 | DisorderedSequence analysisAdd BLAST | 48 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 184 – 211 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 98 – 112 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 119 – 145 | Basic and acidic residuesSequence analysisAdd BLAST | 27 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG1319, Eukaryota |
GeneTreei | ENSGT00940000157377 |
HOGENOMi | CLU_083204_0_0_1 |
OMAi | AHNTEDE |
OrthoDBi | 1234389at2759 |
TreeFami | TF318841 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032647, Mlx |
PANTHERi | PTHR15741:SF25, PTHR15741:SF25, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
A2VCV8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEPGASPED PWVKASSADA HAGEGRAGRA RARRGSGRRG APQLSPESPL
60 70 80 90 100
LSRPRGCRED SSHPACAKVE YAYSDNSLDP GLFVESTHKG SVVSRANSIG
110 120 130 140 150
STSASSVPNT DDEDSDYQQE SYKESYKDRR RRAHTQAEQK RRDAIKRGYD
160 170 180 190 200
DLQTIVPTCQ QQDFSIGSQK LSKAIVLQKT IDYIQFLHKE KKKQEEEVST
210 220 230 240 250
LRKDVTALKI MKVNYEQIVK AHQDNPHEGE DQVSDQVKFN VFQGIMDSLF
260 270 280 290
QSFNASISVA SFQELSACVF SWIEEHCEPQ TLREIVIGVL HQLKNQLY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07072184 Genomic DNA No translation available. BC128702 mRNA Translation: AAI28703.1 CH473948 Genomic DNA Translation: EDM06085.1 |
RefSeqi | NP_001029284.1, NM_001034112.1 |
Genome annotation databases
Ensembli | ENSRNOT00000027116; ENSRNOP00000027116; ENSRNOG00000019983 |
GeneIDi | 360631 |
KEGGi | rno:360631 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07072184 Genomic DNA No translation available. BC128702 mRNA Translation: AAI28703.1 CH473948 Genomic DNA Translation: EDM06085.1 |
RefSeqi | NP_001029284.1, NM_001034112.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000027116 |
Genome annotation databases
Ensembli | ENSRNOT00000027116; ENSRNOP00000027116; ENSRNOG00000019983 |
GeneIDi | 360631 |
KEGGi | rno:360631 |
Organism-specific databases
CTDi | 6945 |
RGDi | 1308590, Mlx |
Phylogenomic databases
eggNOGi | KOG1319, Eukaryota |
GeneTreei | ENSGT00940000157377 |
HOGENOMi | CLU_083204_0_0_1 |
OMAi | AHNTEDE |
OrthoDBi | 1234389at2759 |
TreeFami | TF318841 |
Enzyme and pathway databases
Reactomei | R-RNO-163765, ChREBP activates metabolic gene expression |
Gene expression databases
Bgeei | ENSRNOG00000019983, Expressed in duodenum and 21 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032647, Mlx |
PANTHERi | PTHR15741:SF25, PTHR15741:SF25, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A2VCV8_RAT | |
Accessioni | A2VCV8Primary (citable) accession number: A2VCV8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 20, 2007 |
Last sequence update: | March 20, 2007 | |
Last modified: | January 19, 2022 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |