UniProtKB - A2VCQ7 (A2VCQ7_HUMAN)
Protein
Receptor protein-tyrosine kinase
Gene
EGFR
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:2.7.10.1ARBA annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Kinase, ReceptorARBA annotation, Transferase, Tyrosine-protein kinaseARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:EGFRImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
MembranePTM / Processingi
Keywords - PTMi
GlycoproteinARBA annotation, PhosphoproteinARBA annotationProteomic databases
PeptideAtlasi | A2VCQ7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 66 | Furin-likeInterPro annotationAdd BLAST | 58 | |
Domaini | 89 – 208 | Recep_L_domainInterPro annotationAdd BLAST | 120 | |
Domaini | 233 – 364 | GF_recep_IVInterPro annotationAdd BLAST | 132 |
Keywords - Domaini
Transmembrane, Transmembrane helixARBA annotationFamily and domain databases
CDDi | cd00064, FU, 2 hits |
Gene3Di | 3.80.20.20, 1 hit |
InterProi | View protein in InterPro IPR006211, Furin-like_Cys-rich_dom IPR006212, Furin_repeat IPR032778, GF_recep_IV IPR009030, Growth_fac_rcpt_cys_sf IPR000494, Rcpt_L-dom IPR036941, Rcpt_L-dom_sf |
Pfami | View protein in Pfam PF00757, Furin-like, 1 hit PF14843, GF_recep_IV, 1 hit PF01030, Recep_L_domain, 1 hit |
SMARTi | View protein in SMART SM00261, FU, 2 hits |
SUPFAMi | SSF57184, SSF57184, 2 hits |
i Sequence
Sequence statusi: Fragment.
A2VCQ7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
NLKARGVVPE GKYSFGATCV KKCPRNYVVT DHGSCVRACG ADSYEMEEDG
60 70 80 90 100
VRKCKKCEGP CRKVCNGIGI GEFKDSLSIN ATNIKHFKNC TSISGDLHIL
110 120 130 140 150
PVAFRGDSFT HTPPLDPQEL DILKTVKEIT GFLLIQAWPE NRTDLHAFEN
160 170 180 190 200
LEIIRGRTKQ HGQFSLAVVS LNITSLGLRS LKEISDGDVI ISGNKNLCYA
210 220 230 240 250
NTINWKKLFG TSGQKTKIIS NRGENSCKAT GQVCHALCSP EGCWGPEPRD
260 270 280 290 300
CVSCRNVSRG RECVDKCNLL EGEPREFVEN SECIQCHPEC LPQAMNITCT
310 320 330 340 350
GRGPDNCIQC AHYIDGPHCV KTCPAGVMGE NNTLVWKYAD AGHVCHLCHP
360 370 380
NCTYGCTGPG LEGCPTNGPK IPSIATGMVG TTPLACIY
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 388 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC128419 mRNA Translation: AAI28420.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC128419 mRNA Translation: AAI28420.1 |
3D structure databases
SMRi | A2VCQ7 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A2VCQ7 |
Miscellaneous databases
ChiTaRSi | EGFR, human |
Family and domain databases
CDDi | cd00064, FU, 2 hits |
Gene3Di | 3.80.20.20, 1 hit |
InterProi | View protein in InterPro IPR006211, Furin-like_Cys-rich_dom IPR006212, Furin_repeat IPR032778, GF_recep_IV IPR009030, Growth_fac_rcpt_cys_sf IPR000494, Rcpt_L-dom IPR036941, Rcpt_L-dom_sf |
Pfami | View protein in Pfam PF00757, Furin-like, 1 hit PF14843, GF_recep_IV, 1 hit PF01030, Recep_L_domain, 1 hit |
SMARTi | View protein in SMART SM00261, FU, 2 hits |
SUPFAMi | SSF57184, SSF57184, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A2VCQ7_HUMAN | |
Accessioni | A2VCQ7Primary (citable) accession number: A2VCQ7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 20, 2007 |
Last sequence update: | March 20, 2007 | |
Last modified: | February 10, 2021 | |
This is version 67 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |