UniProtKB - A2VBC4 (PA1_POLPI)
Protein
Phospholipase A1
Gene
N/A
Organism
Polybia paulista (Neotropical social wasp) (Swarm-founding polistine wasp)
Status
Functioni
Catalyzes the hydrolysis of phosphatidylcholine with phospholipase A1 (EC 3.1.1.32) activity (PubMed:17761205). Shows hemolytic activity (PubMed:17761205).1 Publication
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+1 PublicationEC:3.1.1.321 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 156 | NucleophileBy similarity | 1 | |
Active sitei | 184 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 248 | Charge relay systemPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 1-acyl-2-lysophosphatidylserine acylhydrolase activity Source: UniProtKB-EC
- phosphatidylserine 1-acylhydrolase activity Source: UniProtKB-EC
- phospholipase A1 activity Source: UniProtKB-EC
GO - Biological processi
- hemolysis in other organism Source: UniProtKB-KW
- lipid catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Cytolysis, Hemolysis, Lipid degradation, Lipid metabolism |
Enzyme and pathway databases
BRENDAi | 3.1.1.32 9385 |
Protein family/group databases
ESTHERi | polpi-pa1 Insect_Phospholipase |
Names & Taxonomyi
Protein namesi | Recommended name: Phospholipase A11 Publication (EC:3.1.1.321 Publication)Alternative name(s): Allergen: Poly p 11 Publication |
Organismi | Polybia paulista (Neotropical social wasp) (Swarm-founding polistine wasp) |
Taxonomic identifieri | 291283 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Hymenoptera › Apocrita › Aculeata › Vespoidea › Vespidae › Polistinae › Epiponini › Polybia |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Allergenic propertiesi
Causes an allergic reaction in human. Binds to IgE.1 Publication
Keywords - Diseasei
AllergenProtein family/group databases
Allergomei | 3608 Poly p 1 3609 Poly p 1.0101 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | 1 PublicationAdd BLAST | 18 | |
ChainiPRO_5000223755 | 19 – 322 | Phospholipase A11 PublicationAdd BLAST | 304 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 23 ↔ 106 | By similarity | ||
Disulfide bondi | 195 ↔ 200 | By similarity | ||
Disulfide bondi | 238 ↔ 246 | By similarity | ||
Disulfide bondi | 263 ↔ 290 | By similarity | ||
Disulfide bondi | 264 ↔ 315 | By similarity | ||
Disulfide bondi | 283 ↔ 288 | By similarity |
Post-translational modificationi
Contains six disulfide bonds.1 Publication
Is not glycosylated.1 Publication
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Structurei
3D structure databases
ProteinModelPortali | A2VBC4 |
SMRi | A2VBC4 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd00707 Pancreat_lipase_like, 1 hit |
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058 AB_hydrolase IPR002334 Allerg_PlipaseA1 IPR013818 Lipase/vitellogenin IPR033906 Lipase_N IPR000734 TAG_lipase |
PANTHERi | PTHR11610 PTHR11610, 1 hit |
Pfami | View protein in Pfam PF00151 Lipase, 1 hit |
PRINTSi | PR00825 DOLALLERGEN |
SUPFAMi | SSF53474 SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00120 LIPASE_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
A2VBC4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNFKYSILFI CFGTLDRGLI PECPFNEYDI LFFVYTRQQR DGIVLTEETL
60 70 80 90 100
QNYDLFKKST ISRQVVFIDH GFLSNGNNEN FIAMAKALIE KDNFLVISVD
110 120 130 140 150
WKKGACNAFA STLDYLGYST AVGNTRHVGK YVADFTKLLV EQYKVSMSNI
160 170 180 190 200
RLIGHSLGAH TSGFAGKEVQ ELKLNKYSNI DGLDPAGPSF DSNDCPERLC
210 220 230 240 250
ETDAEYVQII HTSNILGVYS KIGTVDFYMN YGSHQPGCGR FFSPSCSHTK
260 270 280 290 300
AVKYLTECIK HECCLIGTPW KKYFSTPKPI SQCTKDTCVC VGLNAKSYPA
310 320
RGSFYVPVEA TAPYCHNEGI KL
Mass spectrometryi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF101736 mRNA Translation: ABN13879.1 AM491805 mRNA Translation: CAM33429.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF101736 mRNA Translation: ABN13879.1 AM491805 mRNA Translation: CAM33429.1 |
3D structure databases
ProteinModelPortali | A2VBC4 |
SMRi | A2VBC4 |
ModBasei | Search... |
MobiDBi | Search... |
Protein family/group databases
Allergomei | 3608 Poly p 1 3609 Poly p 1.0101 |
ESTHERi | polpi-pa1 Insect_Phospholipase |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Enzyme and pathway databases
BRENDAi | 3.1.1.32 9385 |
Family and domain databases
CDDi | cd00707 Pancreat_lipase_like, 1 hit |
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058 AB_hydrolase IPR002334 Allerg_PlipaseA1 IPR013818 Lipase/vitellogenin IPR033906 Lipase_N IPR000734 TAG_lipase |
PANTHERi | PTHR11610 PTHR11610, 1 hit |
Pfami | View protein in Pfam PF00151 Lipase, 1 hit |
PRINTSi | PR00825 DOLALLERGEN |
SUPFAMi | SSF53474 SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00120 LIPASE_SER, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | PA1_POLPI | |
Accessioni | A2VBC4Primary (citable) accession number: A2VBC4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | March 20, 2007 | |
Last modified: | January 16, 2019 | |
This is version 49 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families - Allergens
Nomenclature of allergens and list of entries