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UniProtKB - A2THE9 (A2THE9_DANRE)
Protein
Telomerase reverse transcriptase
Gene
tert
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
UniRule annotationCatalytic activityi
- a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)UniRule annotationARBA annotationEC:2.7.7.49UniRule annotationARBA annotation
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- telomerase activity Source: ZFIN
- telomerase RNA binding Source: GO_Central
- telomerase RNA reverse transcriptase activity Source: GO_Central
- telomeric DNA binding Source: GO_Central
GO - Biological processi
- age-dependent general metabolic decline Source: ZFIN
- erythrocyte maturation Source: ZFIN
- hemopoiesis Source: ZFIN
- intestinal epithelial structure maintenance Source: ZFIN
- spermatogenesis Source: ZFIN
- telomere maintenance via telomerase Source: ZFIN
Keywordsi
Molecular function | Nucleotidyltransferase, RNA-directed DNA polymeraseUniRule annotationARBA annotation, Transferase |
Ligand | MagnesiumUniRule annotation, Metal-bindingUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Telomerase reverse transcriptaseUniRule annotationARBA annotation (EC:2.7.7.49UniRule annotationARBA annotation)Alternative name(s): Telomerase catalytic subunitUniRule annotationARBA annotation |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Organism-specific databases
ZFINi | ZDB-GENE-080405-1, tert |
Subcellular locationi
Nucleus
- nucleus Source: ZFIN
- telomerase catalytic core complex Source: GO_Central
Other locations
- chromosome, telomeric region Source: UniProtKB-SubCell
Keywords - Cellular componenti
Chromosome, NucleusUniRule annotationARBA annotation, TelomereUniRule annotationARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 585 – 903 | Reverse transcriptaseInterPro annotationAdd BLAST | 319 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 317 – 336 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 317 – 331 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Phylogenomic databases
OrthoDBi | 1297956at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR000477, RT_dom IPR021891, Telomerase_RBD IPR003545, Telomerase_RT |
PANTHERi | PTHR12066, PTHR12066, 1 hit |
Pfami | View protein in Pfam PF00078, RVT_1, 1 hit PF12009, Telomerase_RBD, 1 hit |
PRINTSi | PR01365, TELOMERASERT |
SMARTi | View protein in SMART SM00975, Telomerase_RBD, 1 hit |
SUPFAMi | SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS50878, RT_POL, 1 hit |
i Sequence
Sequence statusi: Complete.
A2THE9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGQYSTDGG FRPVLEILRS LYPVVQTLEE FTDGLQFPDG RKPVLLEETD
60 70 80 90 100
GARFKKLLSG LIVCAYTPPQ LRVPAQLSTL PEVLAFTLNH IKRKKLRNVL
110 120 130 140 150
GFGYQCSDVT TSSDPFRFHG DVSQTAASIS TSEVWKRINQ RLGTEVTRYL
160 170 180 190 200
LQDCAVFTTV PPSCVLQVCG EPVYDLLMPR SWSGFFLSNS DNERISGAMR
210 220 230 240 250
KFPAVQKTVA ISKKRTRDNE KYISVKRRRV KETVNNNNGN YRSLCFAISK
260 270 280 290 300
KRAIDNEENI SLKRRRMEET DQVAKIRNEN HESQSFAISK KRARDNEENI
310 320 330 340 350
SLKRQRMEEI DQVAKIRNEN HGSQSWKPAD QRPPRPSQCS IRVLSMLYNG
360 370 380 390 400
RGMKNFLLNR KLKGVGGARR MQGEDLVRMI FLQSESNDSK PKKLPKRFFA
410 420 430 440 450
MVPLFSRLLR QHRKCPYRLF LQRKCAGNPD VKDMESLLKS HSSPYRVYLF
460 470 480 490 500
VRECLRHIIP HELWGCQENQ LHFLSNVKNF LLLGKFERLT LVQLMWRMKV
510 520 530 540 550
QACHWLGPKK RQCASEHRYR EWMLGQCMGW MLSGFVVGLV RAQFYITESM
560 570 580 590 600
GHKHTLRFYR GDVWSRLQDQ AFRAHLCKGQ WRPLSPSQAL KVPNSAVTSR
610 620 630 640 650
IRFIPKTSSM RPITRLSGSR DTLQYFQSCV RVLQNVLSVC VREAPGPMGS
660 670 680 690 700
TVWGWQDIHR RLQDFSPQQK SSPRPLYFVK VDVSGAYDSL PHLKLVEVLK
710 720 730 740 750
EVLGPFAEQS FFLRQYSSVW SDPTRGLRKR FCTKAEMSEP LNMKGFVVDE
760 770 780 790 800
QVSGRLHDAI LVERHSSEVR GGDVFQFFQK MLCSYVIHYD QQMFRQVCGI
810 820 830 840 850
PQGSSVSSLL CNLCYGHMEK ALLKDIAKGG CLMRLIDDFL LITPHLSKAT
860 870 880 890 900
EFLTTLLSGV PDYGCQINPQ KVAVNFPVCV SWVNSGVSVL PSSCLFPWCG
910 920 930 940 950
LMIHTHTLDV YKDYSRYDGL SLRYSLTLGS AHSPSTVMKK LLSVLSIKST
960 970 980 990 1000
DIFLDLRLNS VEAVYRSLYK LILLQALRFH ACVRSLPLGQ SVNRNPSFFL
1010 1020 1030 1040 1050
KMIWRMTRVT NKLLTHINKG LPVCSVDSGG VLQSEAVQLL FCLAFETLFR
1060 1070 1080 1090
RFRSVYHCLI PALHKRKRAL QRELCGITLA RVRQASSPRI PLDFSMRV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF202140 mRNA Translation: ABM92944.1 |
RefSeqi | NP_001077335.1, NM_001083866.1 |
Genome annotation databases
GeneIDi | 796551 |
KEGGi | dre:796551 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF202140 mRNA Translation: ABM92944.1 |
RefSeqi | NP_001077335.1, NM_001083866.1 |
3D structure databases
SMRi | A2THE9 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 796551 |
KEGGi | dre:796551 |
Organism-specific databases
CTDi | 7015 |
ZFINi | ZDB-GENE-080405-1, tert |
Phylogenomic databases
OrthoDBi | 1297956at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR000477, RT_dom IPR021891, Telomerase_RBD IPR003545, Telomerase_RT |
PANTHERi | PTHR12066, PTHR12066, 1 hit |
Pfami | View protein in Pfam PF00078, RVT_1, 1 hit PF12009, Telomerase_RBD, 1 hit |
PRINTSi | PR01365, TELOMERASERT |
SMARTi | View protein in SMART SM00975, Telomerase_RBD, 1 hit |
SUPFAMi | SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS50878, RT_POL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A2THE9_DANRE | |
Accessioni | A2THE9Primary (citable) accession number: A2THE9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 6, 2007 |
Last sequence update: | March 6, 2007 | |
Last modified: | May 25, 2022 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |